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Top Investigators Explore the Complexities of Angiogenesis Cancer
Research The targeting of tumor angiogenesis has evolved into one
of the most widely pursued therapeutic strategies. However, as of
yet, no antiangiogenic agent used as a monotherapy has demonstrated
a survival benefit in a randomized Phase III trial. The combination
of bevacizumab, the first FDA approved angiogenesis inhibitor, with
cytotoxic regimens has led to survival benefits in cancer patients.
This has raised important questions about the complexities inherent
in the clinical application of angiogenesis inhibitors. Compiles
the results of four decades of progress Integrating fundamental
concepts with therapeutic strategies, Anti-Angiogenic Cancer
Therapy promotes the idea that an understanding of the molecular
and cellular regulation of angiogenesis leads to optimal
therapeutic strategies and positive clinical results. It brings
together contributions from leading researchers to provide the most
authoritative and encyclopedic volume available on this subject.
Examines the role of angiogenesis in cancer, including strategies
to prolong the nonangiogenic dormant state of human tumors,
molecular mechanisms and cellular regulation of angiogenesis in
solid tumors and hematologic malignancies, and the regulation of
angiogenesis by the tumor microenvironment. Covers specific
molecular targets for inhibiting angiogenesis in cancer therapy.
Discusses clinical trial design and translational research
approaches essential for identifying and developing effective
angiogenesis inhibitors. Outlines current understanding of the
molecular biology of each cancer type followed by discussions that
examine strategies for targeting angiogenesis in specific cancers.
This volume celebrates progress made in four decades, and more
importantly, it provi
Top Investigators Explore the Complexities of Angiogenesis Cancer
Research The targeting of tumor angiogenesis has evolved into one
of the most widely pursued therapeutic strategies. However, as of
yet, no antiangiogenic agent used as a monotherapy has demonstrated
a survival benefit in a randomized Phase III trial. The combination
of bevacizumab, the first FDA approved angiogenesis inhibitor, with
cytotoxic regimens has led to survival benefits in cancer patients.
This has raised important questions about the complexities inherent
in the clinical application of angiogenesis inhibitors. Compiles
the results of four decades of progress Integrating fundamental
concepts with therapeutic strategies, Anti-Angiogenic Cancer
Therapy promotes the idea that an understanding of the molecular
and cellular regulation of angiogenesis leads to optimal
therapeutic strategies and positive clinical results. It brings
together contributions from leading researchers to provide the most
authoritative and encyclopedic volume available on this subject.
Examines the role of angiogenesis in cancer, including strategies
to prolong the nonangiogenic dormant state of human tumors,
molecular mechanisms and cellular regulation of angiogenesis in
solid tumors and hematologic malignancies, and the regulation of
angiogenesis by the tumor microenvironment. Covers specific
molecular targets for inhibiting angiogenesis in cancer therapy.
Discusses clinical trial design and translational research
approaches essential for identifying and developing effective
angiogenesis inhibitors. Outlines current understanding of the
molecular biology of each cancer type followed by discussions that
examine strategies for targeting angiogenesis in specific cancers.
This volume celebrates progress made in four decades, and more
importantly, it provi
A thought-provoking look at how racial resentment, rather than
racial prejudice alone, motivate a growing resistance among whites
to improve the circumstances faced by racial minorities. In Racial
Resentment in the Political Mind, Darren W. Davis and David C.
Wilson challenge the commonly held notion that all racial
negativity, disagreements, and objections to policies that seek to
help racial minorities stem from racial prejudice. They argue that
racial resentment arises from just-world beliefs and appraisals of
deservingness that help explain the persistence of racial
inequality in America in ways more consequential than racism or
racial prejudice alone. The culprits, as many White people see it,
are undeserving people of color, who are perceived to benefit
unfairly from, and take advantage of, resources that come at
Whites' expense-a worldview in which any attempt at modest change
is seen as a challenge to the status quo and privilege. Yet, as
Davis and Wilson reveal, many Whites have become racially resentful
due to their perceptions that African Americans skirt the "rules of
the game" and violate traditional values by taking advantage of
unearned resources. Resulting attempts at racial progress lead
Whites to respond in ways that retain their social
advantage-opposing ameliorative policies, minority candidates, and
other advancement on racial progress. Because racial resentment is
rooted in beliefs about justice, fairness, and deservingness,
ordinary citizens, who may not harbor racist motivations, may wind
up in the same political position as racists, but for different
reasons.
A thought-provoking look at how racial resentment, rather than
racial prejudice alone, motivate a growing resistance among whites
to improve the circumstances faced by racial minorities. In Racial
Resentment in the Political Mind, Darren W. Davis and David C.
Wilson challenge the commonly held notion that all racial
negativity, disagreements, and objections to policies that seek to
help racial minorities stem from racial prejudice. They argue that
racial resentment arises from just-world beliefs and appraisals of
deservingness that help explain the persistence of racial
inequality in America in ways more consequential than racism or
racial prejudice alone. The culprits, as many White people see it,
are undeserving people of color, who are perceived to benefit
unfairly from, and take advantage of, resources that come at
Whites' expense-a worldview in which any attempt at modest change
is seen as a challenge to the status quo and privilege. Yet, as
Davis and Wilson reveal, many Whites have become racially resentful
due to their perceptions that African Americans skirt the "rules of
the game" and violate traditional values by taking advantage of
unearned resources. Resulting attempts at racial progress lead
Whites to respond in ways that retain their social
advantage-opposing ameliorative policies, minority candidates, and
other advancement on racial progress. Because racial resentment is
rooted in beliefs about justice, fairness, and deservingness,
ordinary citizens, who may not harbor racist motivations, may wind
up in the same political position as racists, but for different
reasons.
Did America s democratic convictions change forever after the
terrorist attacks of September 11? In the wake of 9/11, many
pundits predicted that Americans new and profound anxiety would
usher in an era of political acquiescence. Fear, it was claimed,
would drive the public to rally around the president and tolerate
diminished civil liberties in exchange for security. Political
scientist Darren Davis challenges this conventional wisdom in
Negative Liberty, revealing a surprising story of how September 11
affected Americans views on civil liberties and security. Drawing
on a unique series of original public opinion surveys conducted in
the immediate aftermath of 9/11 and over the subsequent three
years, Negative Liberty documents the rapid shifts in Americans
opinions regarding the tradeoff between liberty and security, at a
time when the threat of terrorism made the conflict between these
values particularly stark. Theories on the psychology of threat
predicted that people would cope with threats by focusing on
survival and reaffirming their loyalty to their communities, and
indeed, Davis found that Americans were initially supportive of
government efforts to prevent terrorist attacks by rolling back
certain civil liberties. Democrats and independents under a
heightened sense of threat became more conservative after 9/11, and
trust in government reached its highest level since the Kennedy
administration. But while ideological divisions were initially
muted, this silence did not represent capitulation on the part of
civil libertarians. Subsequent surveys in the years after the
attacks revealed that, while citizens perceptions of threat
remained acute, trust in the government declined dramatically in
response to the perceived failures of the administration s foreign
and domestic security policies. Indeed, those Americans who
reported the greatest anxiety about terrorism were the most likely
to lose confidence in the government in the years after 2001. As a
result, ideological unity proved short lived, and support for civil
liberties revived among the public. Negative Liberty demonstrates
that, in the absence of faith in government, even extreme threats
to national security are not enough to persuade Americans to
concede their civil liberties permanently. The September 11 attacks
created an unprecedented conflict between liberty and security,
testing Americans devotion to democratic norms. Through lucid
analysis of concrete survey data, Negative Liberty sheds light on
how citizens of a democracy balance these competing values in a
time of crisis."
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