Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and thatitisrepresentedinalmosteverycelltype. Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but the degree of complexity involved is enormous. This is particularly true for endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof thisvolume. Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld, providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof centraldiseasestates. The?rstpartprovidesabackgroundand"toolbox",detailingwhatisknown abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey in?uencesynapticactivity. Itgoesontodescribethegeneticandpharmacological methodsavailableforinvestigatingthesystem. The second part describes endocannabinoid roles in key systems controlling appetite,pain,memoryandlearning,stressresponsesandreproduction. The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi- phrenia,feedingdisordersandTourette'ssyndrome. Giventheenormousamountofinformationavailableandtherateofprogressin research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom DavidKendall StephenAlexander v Contents PartI Biochemistry,Pharmacology,GeneticsandChemistry 1 TheLifeCycleoftheEndocannabinoids:Formation andInactivation...3 StephenP. H. AlexanderandDavidA. Kendall 2 EndocannabinoidReceptorPharmacology ...37 KenMackieandBettyYao 3 EndocannabinoidReceptors:CNSLocalizationoftheCB 1 CannabinoidReceptor...65 Istva'nKatona 4 PharmacologicalToolsinEndocannabinoidNeurobiology...87 MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem ...111 KrisztinaMonoryandBeatLutz 6 EndocannabinoidSignalinginNeuralPlasticity ...141 BradleyE. Alger 7 LessonsfromNonmammalianSpecies ...173 KenSoderstrom PartII PhysiologyandPathophysiology 8 RolesoftheEndocannabinoidSysteminLearning andMemory ...201 GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9 EndocannabinoidsandtheNon-HomeostaticControl ofAppetite ...231 TimC. Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly PregnancyEvents...255 XiaofeiSunandSudhansuK. Dey 11 TargetingtheCannabinoidSystemtoProduceAnalgesia ...275 DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12 IntegrationofEndocannabinoidSignalingintotheNeural NetworkRegulatingStress-InducedActivationofthe Hypothalamic-Pituitary-AdrenalAxis ...289 BorisB. GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction ...309 ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14 RoleofEndocannabinoidSignalinginAnxietyandDepression...347 SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity...373 CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto 16 Schizophrenia...387 F. Markus 17 Tourette'sSyndrome...397 KirstenR. Mu..ller-Vahl Index ...411 Contributors StephenP. H. Alexander SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN- tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments of Physiology and Psychiatry, University of Maryland School of Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201, USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and Center of Applied Biomedical Research (C. R. B. A. ), DepartmentofInternalMedicineandGastroenterology,S. Orsola-MalpighiHos- tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy VictoriaChapman SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH, UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments of Pharmacology, Pediatrics and Cell & Developmental Biology, Division of Reproductive and Developmental Biology, Vanderbilt University MedicalCenter,Nashville,TN37232,USA;sk. dey@vanderbilt. edu StevenR.

A luxury omnibus of classic supernatural war stories from the Golden Age of comics - expanded and updated in definitive edition. Buried deep underground are the remains of Wehrmacht soldier, Hans Schmitt, and his diary, which journals his eerie encounter with the Romanian Captain Constanta and his platoon of blood-sucking freaks! Back in 1943, with the Russians willing to fight until their last man in order to defend Stalingrad, Panzergrenadier Richter discovers Constanta’s secret and learns than sometimes your allies can be just as dangerous as the enemy! Featuring the breathtaking art of Carlos Ezquerra (Judge Dredd) and Colin MacNeil (America, Chopper: Song of the Surfer), with stories from Gerry Finley Day (Rogue Trooper), David Bishop (Thrill-Power Overload), and recent classics from Ian Edginton (Stickleback, Scarlet Traces), Dave Kendall (Fall of Deadworld).

Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and thatitisrepresentedinalmosteverycelltype. Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but the degree of complexity involved is enormous. This is particularly true for endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof thisvolume. Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld, providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof centraldiseasestates. The?rstpartprovidesabackgroundand"toolbox",detailingwhatisknown abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey in?uencesynapticactivity. Itgoesontodescribethegeneticandpharmacological methodsavailableforinvestigatingthesystem. The second part describes endocannabinoid roles in key systems controlling appetite,pain,memoryandlearning,stressresponsesandreproduction. The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi- phrenia,feedingdisordersandTourette'ssyndrome. Giventheenormousamountofinformationavailableandtherateofprogressin research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom DavidKendall StephenAlexander v Contents PartI Biochemistry,Pharmacology,GeneticsandChemistry 1 TheLifeCycleoftheEndocannabinoids:Formation andInactivation...3 StephenP. H. AlexanderandDavidA. Kendall 2 EndocannabinoidReceptorPharmacology ...37 KenMackieandBettyYao 3 EndocannabinoidReceptors:CNSLocalizationoftheCB 1 CannabinoidReceptor...65 Istva'nKatona 4 PharmacologicalToolsinEndocannabinoidNeurobiology...87 MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem ...111 KrisztinaMonoryandBeatLutz 6 EndocannabinoidSignalinginNeuralPlasticity ...141 BradleyE. Alger 7 LessonsfromNonmammalianSpecies ...173 KenSoderstrom PartII PhysiologyandPathophysiology 8 RolesoftheEndocannabinoidSysteminLearning andMemory ...201 GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9 EndocannabinoidsandtheNon-HomeostaticControl ofAppetite ...231 TimC. Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly PregnancyEvents...255 XiaofeiSunandSudhansuK. Dey 11 TargetingtheCannabinoidSystemtoProduceAnalgesia ...275 DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12 IntegrationofEndocannabinoidSignalingintotheNeural NetworkRegulatingStress-InducedActivationofthe Hypothalamic-Pituitary-AdrenalAxis ...289 BorisB. GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction ...309 ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14 RoleofEndocannabinoidSignalinginAnxietyandDepression...347 SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity...373 CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto 16 Schizophrenia...387 F. Markus 17 Tourette'sSyndrome...397 KirstenR. Mu..ller-Vahl Index ...411 Contributors StephenP. H. Alexander SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN- tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments of Physiology and Psychiatry, University of Maryland School of Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201, USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and Center of Applied Biomedical Research (C. R. B. A. ), DepartmentofInternalMedicineandGastroenterology,S. Orsola-MalpighiHos- tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy VictoriaChapman SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH, UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments of Pharmacology, Pediatrics and Cell & Developmental Biology, Division of Reproductive and Developmental Biology, Vanderbilt University MedicalCenter,Nashville,TN37232,USA;sk. dey@vanderbilt. edu StevenR.

Can humanity escape the icy clutches of Death? The psychotic Chief Judge Casey Tweed has dethroned and killed Judge Death and taken over Death's mission to murder every living creature on the planet. The neighbouring Soviets have seen the chaos as an ideal time to launch an attack on their American enemies. As numerous battles rage a small group of rebels led by Judge Fairfax - some living, some already turned into the undead - launch a desperate effort to save their city from being converted into a necropolis, but it all seems too little too late. The Dark Judges are already spreading their contagion across the globe and in the depths of space, exterminating all life under the orders of Chief Judge Tweed. However, both the forces of death and the forces of life about to learn, just because Judge Death is dead, doesn't mean that he is gone... The acclaimed series from Kek-W (The Order) and Dave Kendall (Dreams of Deadworld) continues in this lavish hardback collection, including never seen before concept art and sketches.

Are your exams coming up? Are you drowning in textbooks and lecture notes and wondering where to begin? Take the "FASTtrack" route to successful study for your examinations. "FASTtrack" provides the ultimate lecture notes and is a must-have for all pharmacy students wanting to study and test themselves for forthcoming exams. "FASTtrack: Pharmacology" provides a brief account of drug action, as either a study or revision aid. In doing this, the authors have generally taken a therapeutic area and considered the major classes of drugs, their actions and, to a limited degree, their uses. There are many excellent brief guides to pharmacology and so their second aim is to present a study guide which deals with molecular pharmacology at a more advanced level, so that the book is also useful for advanced pharmacology studied in the later years of pharmacy and science degrees. This study guide should therefore be useful at each level of undergraduate study.New in this edition: each chapter completely updated to take account of recent changes, and include future drugs; multiple choice tests; new chapters on immunopharmacology, oral contraceptives and local anaesthetics; and, greater use of summary tables.