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The fourth edition of this text constitutes a continuation of 20
years of coverage of traumatic brain injury, and broadens the
discussion of acquired brain injury. Within TBI, the paradigm shift
from an injury occurring at a point in time to a disease entity of
a chronic nature is changing the discussion of diagnosis,
management, treatment and outcome assessment. Disease specification
that differentiates TBIs by the mechanism of injury, the exact
nature of the injury, the extent of injury, presence of
co-morbidities and their exact nature, gender, age, race, and
genome are emerging as crucial. Disease differentiation has
impacted diagnosis, treatment and outcome.
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