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Biochemistry And Genetics of RecQ-Helicases provides a background
into the role of helicases in general and RecQ helicases
specifically in DNA repair. Helicases- enzymes which break down
hydrogen bonds between nucleic acid strands in a nucleoside
triphosphate-dependent manner-are ubiquitous in biology,
participating in processes as diverse as replication, repair,
recombination, transcription, and translation. The RecQ-family
helicases are a group of helicases which have important roles in
the maintenance of genomic stability in many organisms. In humans,
mutations in three RecQ-family helicases lead to disease. This book
thoroughly examines these helicases. Mutations in the BLM gene lead
to Bloom syndrome, a disorder characterized by a susceptibility to
many types of cancer. Mutations in the WRN gene cause Werner
syndrome, a disease which in some respects resembles premature
aging. Finally, mutations in a newly characterized RecQ-family
member, RECQ4, may lead to the very rare recessive disorder
Rothmund-Thomson syndrome, a condition characterized by
developmental abnormalities and some aging-like manifestations.
This book is intended for any researchers invested in these
particular disorders, or with a general interest in DNA.
Biochemistry And Genetics of RecQ-Helicases provides a background
into the role of helicases in general and RecQ helicases
specifically in DNA repair. Helicases- enzymes which break down
hydrogen bonds between nucleic acid strands in a nucleoside
triphosphate-dependent manner-are ubiquitous in biology,
participating in processes as diverse as replication, repair,
recombination, transcription, and translation. The RecQ-family
helicases are a group of helicases which have important roles in
the maintenance of genomic stability in many organisms. In humans,
mutations in three RecQ-family helicases lead to disease. This book
thoroughly examines these helicases. Mutations in the BLM gene lead
to Bloom syndrome, a disorder characterized by a susceptibility to
many types of cancer. Mutations in the WRN gene cause Werner
syndrome, a disease which in some respects resembles premature
aging. Finally, mutations in a newly characterized RecQ-family
member, RECQ4, may lead to the very rare recessive disorder
Rothmund-Thomson syndrome, a condition characterized by
developmental abnormalities and some aging-like manifestations.
This book is intended for any researchers invested in these
particular disorders, or with a general interest in DNA.
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