Biochemistry and Genetics of Recq-Helicases (Paperback, Softcover reprint of the original 1st ed. 2001)

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	March 2013
First published:	2001
Authors:	David B. Lombard
Dimensions:	235 x 155 x 5mm (L x W x T)
Format:	Paperback
Pages:	92
Edition:	Softcover reprint of the original 1st ed. 2001
ISBN-13:	978-1-4613-5537-3
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Evolution Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > General
LSN:	1-4613-5537-0
Barcode:	9781461355373

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