Used by generations of physicians who encounter patients with dermatological diseases, Lever's Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a "primer" on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis-all in an easy-to-navigate, highly readable format. More than 2,000 larger, full-color illustrations, including photomicrographs and clinical photographs, help you visualize and make the most of the clinical diagnostic process Clinical Summaries provide a concise clinical review before presenting histologic features, and Principles of Management sections summarize today's complex treatment modalities in one convenient place Ultrastructural, immunohistochemical, and molecular techniques are discussed where they have value in identifying particular diseases Numerous tables summarize or compare and contrast similar groups of diseases A chapter dedicated to algorithmic classification of skin diseases according to histologic pattern features helps you develop a differential diagnosis for unknown cases An outstanding resource for dermatopathologists, pathologists, and dermatologists in training, practice, and teaching Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

In surgical pathology practice, distinguishing malignant from benign melanocytic lesions represents one of the major problem areas. Failure to diagnose a malignant melanoma can have catastrophic results, but separating melanomas from their simulants is often difficult, and over-diagnosis of melanoma is also inappropriate. This edition presents a comprehensive account of benign and malignant melanocytic lesions. The benign lesions encompass the major simulants of melanoma. In addition, some of them, such as dysplastic nevi, have significance as markers of individuals at increased risk for the development of melanoma. It has become ever more apparent, especially with the recent advent of molecular classification, that melanoma is not one disease, and that prognosis in melanoma can vary considerably from lesions that present minimal risk, to dangerous malignancies at opposite ends of a spectrum. The details of therapy for these lesions are very different and are determined for the most part by their diagnostic and prognostic features as judged by microscopy. This edition explains in detail the use of attributes for microstaging and for prediction of prognosis in melanoma, including discussion of the latest AJCC staging system. More importantly, however, it provides a richly-illustrated roadmap for diagnosis of the entire spectrum of melanocytic tumours. Discussion of the lesions is firmly grounded in their clinical significance, with detailed descriptions of clinical features often accompanied by clinical images. Lesions in general are illustrated in multiple microscopic images ranging from scanning magnification to high power. Cytologic as well as architectural features are clearly delineated. Pathophysiology, epidemiology, and molecular attributes are also discussed. This work will serve as a comprehensive text for learning on the part of trainees, and also as an invaluable diagnostic reference for more experienced diagnosticians in daily practice.