The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com pounds are not only the forms of folate co-factors that accumulate within cells, but, in addition, are the preferred substrates for folate dependent reactions in eukaryotic cells. More recently attention has turned to the potential importance of the polyglutamyl derivatives of methotrexate that have been detected in normal and malignant cells both in vitro and in vivo. The biochemical trans formation of this important chemotherapeutic agent is of particular significance since polyglutamyl derivatives of methotrexate are not only potent inhibitors of the target enzyme, but have quite different cellular pharmacokinetics than the parent monoglutamate. Hence, nearly three and a half decades after 4-aminoantifolates were first applied clinically in the treatment of human neoplasms, we have begun to appreciate a new dimension in antifolate pharmaco logy which may have profound implications for our understanding of the mechanism of the cytotoxicity and selectivity of this class of agents. With the development of highly sensitive methodology for the rapid detection of folyl and antifolyl polyglutamates, it is now possible to define in depth the intracellular transformation of these agents and their role in determining antifolate action against normal and malignant cells. This information will very likely influence how regimens with methotrexate and related antifolates will be further developed and employed clinically."

Our Genes, Our Choices: How Genotype and Gene Interactions Affect Behavior, Second Edition explains how the complexity of human behavior, including concepts of free will, derives from a relatively small number of genes, which direct neurodevelopmental sequences. Are people free to make choices, or do genes determine behavior? Paradoxically, the answer to both questions is "yes," because of neurogenetic individuality, a new theory with profound implications. Here, author David Goldman uses judicial, political, medical, and ethical examples to illustrate that this lifelong process is guided by individual genotype, molecular and physiologic principles, as well as by randomness and environmental exposures, a combination of factors that we choose and do not choose. Written in an authoritative yet accessible style, the book includes practical descriptions of the function of DNA, discusses the scientific and historical bases of genethics, and introduces the topics of epigenetics and the predictive power of behavioral genetics. In the decade since the first edition published, knowledge of genetic influences on the neurogenetic underpinnings of behavior has been transformed by genomic technologies. Genome-Wide Association studies, for example, have revealed that hundreds of genes influence vulnerability to psychiatric disease and innate predisposition to risk-taking behaviors. This new edition has been thoroughly revised to focus on free will and its neurogenetic origins. In addition, the use of polygenic scores for behavioral prediction are discussed in-depth, reflecting the GWAS (Genome-Wide Association Study) revolution and combined use of genetic predictors in polygenic scores. Sections on epigenetics are also substantially expanded throughout, better defined, and tied to neuroplasticity and gene-environment interaction. Figures and illustrations have been added or improved throughout, and disease nosology and terminology has been updated. 

"Our Genes, Our Choices: How Genotype and Gene Interactions Affect Behavior" explains how the complexity of human behavior, including concepts of free will, derives from a relatively small number of genes, which direct neurodevelopmental sequence. Are people free to make choices, or do genes determine behavior? Paradoxically, the answer to both questions is "yes," because of neurogenetic individuality, a new theory with profound implications.

Author David Goldman uses judicial, political, medical, and ethical examples to illustrate that this lifelong process is guided by individual genotype, molecular and physiologic principles, as well as by randomness and environmental exposures, a combination of factors that we choose and do not choose.

Written in an authoritative yet accessible style, the book includes practical descriptions of the function of DNA, discusses the scientific and historical bases of genethics, and introduces topics of epigenetics and the predictive power of behavioral genetics.
Poses and resolves challenges to moral responsibility raised by modern genetics and neuroscienceAnalyzes the neurogenetic origins of human behavior and free will Written by one of the world's most influential neurogeneticists, founder of the Laboratory of Neurogenetics at the National Institutes of Health

This is the translation of the Memorial (Yizkor) Book of Jewish community of Drohichin, Belarus. This history of Drohitchin/Drahichyn --in Belarus -- covers the nearly 500-year old Jewish community that had almost 5,000 Jewish residents at the start of World War II. This book is both history and memoir, and it includes poetry, tributes, and many photos. Also contained is a necrology of the Shoah victims from Drohitchin and nearby towns murdered in the two Drohitchin massacres ( July 25 and October 15, 1942). Former Drohitchin residents and descendants contributed first-hand accounts to this book so that future generations could learn about the long history of this once vibrant Jewish community. Read and treasure this heart-wrenching account of a Jewish world that no longer exists. Drohitchin is located 40 miles W of Pinsk, 33 miles East of Kobryn, 16 miles East of Antopol. Not to be confused with the smaller town of Drohiczyn, Poland, 49 miles WNW of Brest]. Alternate names for the town: Drahichyn Belarussian], Drogichin Russsian], Drohiczyn Polish], Drohitchin Yiddish], Drahitschyn German], Drogi inas Lithuanian], Drohichin, Drohiczyn Poleski, Drahi yn, Dorohiczyn. Published by the Yizkor Books in Print Project, part of Yizkor Books Project of JewishGen, Inc. 736 pages, 8.5" by 11," hard cover, including all photos and other images and new lists of residents compiled recently

In recent times, the boundary between living and non-living has been blurred by advances in genomics, cell biology, and molecular neuroscience, whereby humans are repaired, enhanced, or made anew. Scientists and physicians are now able to keep cells, organs, and bodies alive indefinitely and can return cells or DNA to our bodies and make new cells for the purpose of treating disease or growing new tissue. Meanwhile, transhuman technologies create illusions of immortality. Immortal: Our Cells, DNA, and Bodies synthesizes what we know about life and death from a genetic, molecular, and cellular perspective, demarcates limits of knowledge, and poses new questions. Award-winning researcher and writer David Goldman examines in-depth three keys to understanding the nature and continuity of life: 1) epigenetic (ephemeral) vs genetic (durable) transgenerational memory; 2) life's cellular nature, and the ability to make bodies from cells; and 3) the distinction between bodies and persons. Grounded in recent scientific evidence and real-life cases that test our historical understanding of life and death, Goldman probes the nature of molecular continuity in the face of mortal extinction, encompassing how changes to the DNA code can be both long-lasting and transgenerational, and the continuous nature of cellular and molecular information transmission. In tying these themes together, Immortal asks us to apply fresh scientific concepts to examine, for ourselves, the continuity of being in the face of mortality.

What would you do if your four-year-old son was abducted--by your spouse?In June 2004, David Goldman took his Brazilian wife, Bruna, and their son, Sean, to the airport. She told him that they would be returning to New Jersey after a two-week vacation. Once there, however, Bruna informed Goldman that she was staying in Brazil--and keeping Sean.

In the courts, Goldman found himself outmaneuvered by the legal machinations of Bruna's new husband, a member of one of Brazil's most powerful families. But Goldman never gave up, appealing to the media and the highest levels of the U.S. government for help. A Father's Love is the story of Goldman's incredible five-year battle to reunite with his abducted child - and an inspiring celebration of an ordinary man's love for his son.