Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

The behavior of materials at the nanoscale is a key aspect of modern nanoscience and nanotechnology. This book presents rigorous mathematical techniques showing that some very useful phenomenological properties which can be observed at the nanoscale in many nonlinear reaction-diffusion processes can be simulated and justified mathematically by means of homogenization processes when a certain critical scale is used in the corresponding framework.

This story begins in the depths of a lost mind... a mind locked away in a mental asylum for many years. The house on Cumana Point is the key to unlocking a troubled past. It is a story of a man who desperately needs to find out where he fits in the world and has to rely on bits and pieces associated with the house, even though he has no idea of his connection to the house. As the story progresses, George Lawrence becomes aware that he is closely tied to this ghostly house and only with time will it reveal its secrets... his secrets. George Lawrence returns to the house on Cumana Point where, though abandoned for more than twenty years, he discovers snippets of his life and rekindles memories of his past. George searches for answers to questions that have taken place in a time shortly after the second World War when the Caribbean island of Trinidad is holding onto a political system that is corrupt and greedy. There is hope that George - a young, politically well-placed lawyer - can make a difference. This is not to be as he faces many challenges preventing him from attaining his goal of a democratic and just government. George's journey becomes his present, his past and his future. Each step opens and closes a door to his past, clarifies his present, and determines his future.

George learns how to use the potty in this helpful board book. Based on the hit TV show on Nick Jr.!

Peppa's little brother George uses the potty for the first time in this handy board book! It's a great tool for kids who are also toilet training.

Next Generation Mobile Broadcasting provides an overview of the past, present, and future of mobile multimedia broadcasting. The first part of the book-Mobile Broadcasting Worldwide-summarizes next-generation mobile broadcasting technologies currently available. This part covers the evolutions of the Japanese mobile broadcasting standard ISDB-T One-Seg, ISDB-Tmm and ISDB-TSB; the evolution of the South Korean T-DMB mobile broadcasting technology AT-DMB; the American mobile broadcasting standard ATSC-M/H; the Chinese broadcasting technologies DTMB and CMMB; second-generation digital terrestrial TV European standard DVB-T2 and its mobile profile T2-Lite; and the multicast/broadcast extension of 4G LTE cellular standard E-MBMS. This part includes a chapter about a common broadcast specification of state-of-the-art 3GPP and DVB standards to provide a broadcast overlay optimized for mobile and operated in conjunction with a broadband unicast access. It also contains an overview chapter on a new High-Efficiency Video Coding (HEVC) standard that is expected to provide significantly improved coding efficiency compared to current MPEG-4 AVC video coding. The second part of the book-Next-Generation Handheld DVB Technology: DVB-NGH -describes the latest mobile broadcast technology known as Digital Video Broadcasting-Next-Generation Handheld (DVB-NGH), which is expected to significantly outperform all existing technologies in both capacity and coverage. DVB-NGH introduces new technological solutions that along with the high performance of DVB-T2 make DVB-NGH a powerful next-generation mobile multimedia broadcasting technology. In fact, DVB-NGH can be regarded as the first 3G broadcasting system because it allows for the possibility of using multiple input multiple output MIMO antenna schemes to overcome the Shannon limit of single antenna wireless communications. DVB-NGH also allows the deployment of an optional satellite component forming a hybrid terrestrial-satellite network topology to improve coverage in rural areas where the installation of terrestrial networks is economically unfeasible. Although the commercial deployment of DVB-NGH is nowadays unclear after its standardization, it will be a reference point for future generations of digital terrestrial television technologies. Edited by a member of the DVB-NGH standardization group, the book includes contributions from a number of standardization groups worldwide-including Digital Video Broadcasting (DVB) in Europe; Advanced Television Systems Committee (ATSC) in the US, Korea, Japan, and China; Third Generation Partnership Project (3GPP); and the Moving Picture Experts Group (MPEG).

Biological systems are extremely complex and have emergent properties that cannot be explained or even predicted by studying their individual parts in isolation. The reductionist approach, although successful in the early days of molecular biology, underestimates this complexity. As the amount of available data grows, so it will become increasingly important to be able to analyse and integrate these large data sets. This book introduces novel approaches and solutions to the Big Data problem in biomedicine, and presents new techniques in the field of graph theory for handling and processing multi-type large data sets. By discussing cutting-edge problems and techniques, researchers from a wide range of fields will be able to gain insights for exploiting big heterogonous data in the life sciences through the concept of 'network of networks'.

Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

Next Generation Mobile Broadcasting provides an overview of the past, present, and future of mobile multimedia broadcasting. The first part of the book-Mobile Broadcasting Worldwide-summarizes next-generation mobile broadcasting technologies currently available. This part covers the evolutions of the Japanese mobile broadcasting standard ISDB-T One-Seg, ISDB-Tmm and ISDB-TSB; the evolution of the South Korean T-DMB mobile broadcasting technology AT-DMB; the American mobile broadcasting standard ATSC-M/H; the Chinese broadcasting technologies DTMB and CMMB; second-generation digital terrestrial TV European standard DVB-T2 and its mobile profile T2-Lite; and the multicast/broadcast extension of 4G LTE cellular standard E-MBMS. This part includes a chapter about a common broadcast specification of state-of-the-art 3GPP and DVB standards to provide a broadcast overlay optimized for mobile and operated in conjunction with a broadband unicast access. It also contains an overview chapter on a new High-Efficiency Video Coding (HEVC) standard that is expected to provide significantly improved coding efficiency compared to current MPEG-4 AVC video coding. The second part of the book-Next-Generation Handheld DVB Technology: DVB-NGH -describes the latest mobile broadcast technology known as Digital Video Broadcasting-Next-Generation Handheld (DVB-NGH), which is expected to significantly outperform all existing technologies in both capacity and coverage. DVB-NGH introduces new technological solutions that along with the high performance of DVB-T2 make DVB-NGH a powerful next-generation mobile multimedia broadcasting technology. In fact, DVB-NGH can be regarded as the first 3G broadcasting system because it allows for the possibility of using multiple input multiple output MIMO antenna schemes to overcome the Shannon limit of single antenna wireless communications. DVB-NGH also allows the deployment of an optional satellite component forming a hybrid terrestrial-satellite network topology to improve coverage in rural areas where the installation of terrestrial networks is economically unfeasible. Although the commercial deployment of DVB-NGH is nowadays unclear after its standardization, it will be a reference point for future generations of digital terrestrial television technologies. Edited by a member of the DVB-NGH standardization group, the book includes contributions from a number of standardization groups worldwide-including Digital Video Broadcasting (DVB) in Europe; Advanced Television Systems Committee (ATSC) in the US, Korea, Japan, and China; Third Generation Partnership Project (3GPP); and the Moving Picture Experts Group (MPEG).

This book introduces magnetic bearings--mechatronic devices that produce contact-free electromagnetic force to support a load, such as a moving train or a spinning rotor. Compared to traditional bearings, magnetic bearings offer several advantages: no friction, low heat generation, no required lubrication, quiet operation, and fast and stable rotation. For these reasons, magnetic bearings have been used in rotary ventricular assist devices (VADs) to increase design life, reduce or eliminate material wear and bearing maintenance, as well as to increase biocompatibility by eliminating high fluid stresses and heat generation, both of which are associated with hemolysis, platelet activation and aggregation, and thrombus growth. The book covers the principles of these bearings, how they are used in integrated control and electronics systems, and useful information on several major brands of current assist devices.

This story begins in the depths of a lost mind... a mind locked away in a mental asylum for many years. The house on Cumana Point is the key to unlocking a troubled past. It is a story of a man who desperately needs to find out where he fits in the world and has to rely on bits and pieces associated with the house, even though he has no idea of his connection to the house. As the story progresses, George Lawrence becomes aware that he is closely tied to this ghostly house and only with time will it reveal its secrets... his secrets. George Lawrence returns to the house on Cumana Point where, though abandoned for more than twenty years, he discovers snippets of his life and rekindles memories of his past. George searches for answers to questions that have taken place in a time shortly after the second World War when the Caribbean island of Trinidad is holding onto a political system that is corrupt and greedy. There is hope that George - a young, politically well-placed lawyer - can make a difference. This is not to be as he faces many challenges preventing him from attaining his goal of a democratic and just government. George's journey becomes his present, his past and his future. Each step opens and closes a door to his past, clarifies his present, and determines his future.

Community activist Carolyn McLaughlin takes us on a journey of the South Bronx through the eyes of its community members. Facing burned-out neighborhoods of the 1970s, the community fought back. McLaughlin illustrates the spirit of the community in creating a vibrant, diverse culture and its decades-long commitment to develop nonprofit housing and social-services, and to advocate for better education, health care, and a healthier environment. For the South Bronx to remain a safe haven for poor families, maintaining affordable housing is the central-but most challenging-task. South Bronx Battles is the comeback story of a community that was once in crisis but now serves as a beacon for other cities to rebuild, while keeping their neighborhoods affordable.

Community activist Carolyn McLaughlin takes us on a journey of the South Bronx through the eyes of its community members. Facing burned-out neighborhoods of the 1970s, the community fought back. McLaughlin illustrates the spirit of the community in creating a vibrant, diverse culture and its decades-long commitment to develop nonprofit housing and social-services, and to advocate for better education, health care, and a healthier environment. For the South Bronx to remain a safe haven for poor families, maintaining affordable housing is the central-but most challenging-task. South Bronx Battles is the comeback story of a community that was once in crisis but now serves as a beacon for other cities to rebuild, while keeping their neighborhoods affordable.