This new edition of Animal Models in Cardiovascular Research describes historical and recent advances in our understanding of the cardiovascular system from studies conducted in a variety of animal models. Since the last edition we have witnessed an explosion in the use of both congenic and transgenic animals. The use of specific knock-in and knock-out transgenic models has resulted in an avalanche of genetic, molecular and protein-based information that, potentially, could result in an amazing new array of treatment and management options. However, the results of these studies also introduce a sometime bewildering array of redundant, overlapping and competing molecular pathways involved in both physiological and pathological responses.

This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information. It is significantly different than the previous two editions. Chapter 1 is updated from the previous editions addressing general principles of animal selection. It also provides expanded tables of normal physiological values for easy reference. Chapter 2 covers preoperative care, pre-anesthesia, chemical restraint, and includes a significantly expanded section on pain recognition and analgesia particularly in rodents. Chapter 3 provides a summary of normal cardiovascular parameters obtained from intact, awake animals. The data have been rearranged in outline rather than the previous tabular form hopefully resulting in easier reference.

Chapter 4 addresses the techniques, problems and pitfalls of measuring cardiac function in animals. There is an emphasis on the proper use of these measurements to develop new treatment and management strategies as well as using them to study mechanisms of disease. Chapter 5 emphasizes the techniques, problems and pitfalls involved in the measurement of arterial function and ventricular/arterial coupling dynamics. Again the emphasis is on the use of these parameters to develop new treatment and management strategies and for studying the mechanisms of disease. Chapter 6 is a all new chapter dealing specifically with the problems and pitfalls inherent in using isolated heart preparations. The need for this chapter became apparent because so much information was published using obviously non-physiologic preparations. The use of both pumping and non-pumping preparations are described along with techniques necessary for using hearts from larger species where oxygen carrying capacity of the perfusate is critical. The importance of hypoxia and anoxia in the interpretation of results is discussed.

Chapter 7 focuses on the cardiovascular effects of the post-operative analgesic drugs commonly used today and how to avoid potential problems resulting from these effects when reporting experimental data. These data are also presented in outline form rather than the tabular format used in the two previous editions. Chapter 8 addresses the use of naturally occurring animal models of valvular and infectious cardiovascular disease. The information presented has been updated and expanded from the second edition. Chapter 9 examines iatrogenic models of ischemic heart disease.

Chapter 10 is new. It provides a review of iatrogenic, transgenic and naturally occurring animal models of cardiomyopathy and heart failure. Chapter 11 includes new, updated and revised information reviewing iatrogenic and transgenic models of hypertension. Chapter 12 contains new, and updated information on iatrogenic and transgenic models of atherosclerotic disease.

Chapter 13 is completely new material dealing with animal models for the study of neurohumeral and central nervous system control of the cardiovascular system. Chapter 14 is also new. It provides examples of cardiovascular studies involving the use of specific transgenic models not normally associated with the cardiovascular system, such as estrogen receptor knockouts, to study cardiovascular function.

The first biography of Anne Damer since 1908, The Life of Anne Damer: Portrait of a Regency Artist, by Jonathan Gross, draws on Damer s notebooks and previously unpublished letters to explore the life and legacy of England s first significant female sculptor. Best known for her portraits of dogs and other animals, Damer also created busts of England s most important political heroes, sometimes within days or hours of their historical accomplishments. This in-depth biography traces her life during the American Revolution, the French Revolution, the Peace of Amiens and the Hundred Days. Damer was convinced that art could have significant political influence, sending her bust of Nelson to the King of Tanjore to encourage trade with India. Her art stands at the transition between neoclassicism and romanticism and provides a wealth of insight into 19th century British sculpture. In the last twenty years, there has been a strong revival of interest in Damer s life, particularly in gay and lesbian studies due to her famous relationship with author Mary Berry. This text serves as a deeper investigation of this fascinating and important figure of British art history. The emotional menage a trois of Anne Damer, Mary Berry, and Horace Walpole forms the heart of this new biography. Gross contends that all three individuals, had they led more conventional lives, would never have given the world the literary and artistic gifts they bestowed in the form of Strawberry Hill, Belmour, and Fashionable Friends. The struggles they faced will encourage modern readers to appreciate anew the fluidity of sexual identity and passionate friendship, as well as the restraints put in place by society to control them. Anne Damer s life has much to teach a new generation concerned with the complex relationship between love, art, and politics. The Life of Anne Damer will interest historians of Georgian England, and readers in the fine arts, literature, and history.

Poets have been writing in Hebrew since Biblical times. One of the oldest tongues known to man, its rich simplicity has inspired poetry whose hallmarks are immediacy and passion. Although much of Hebrew poetry has traditionally focused on the religious and philosophical, the theme of love has remained vivid throughout the centuries of Jewish life. This beautifully illustrated book of more than ninety love lyrics translated from the Hebrew is a celebration of this enduring theme. Ranging from The Song of Songs to poetry from modern Israel, there are poems of praise and devotion, quiet reflection, joyous celebration, carefree humor, and sensuous beauty. Shraga Weil's delicate, evocative illustrations are the perfect complement to the works they accompany. Included are the works of King David, the Psalmist, King Solomon, author of The Song of Songs, Nobel Laureate S.Y. Agnon, as well as Yehuda Halevi, Chaim Nachman Bialik, Saul Tchernikhovsky, Rachel, Uri Zvi Greenburg, Moses Ibn-Ezra, Judah Al-Harizi, Natan Alterman, David Fogel, T. Carmi, Leah Goldberg, and others.

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ The Glory And The Hardships Of The Medical Life: Being The Valedictory Address Delivered At The Philadelphia Academy Of Music, March 11, 1875, Before The Trustees, Faculty, And Students Of The Jefferson Medical College ... Samuel David Gross, Jefferson Medical College P. Madeira, 1875 Biography & Autobiography; Medical; Biography & Autobiography / Medical; Medical / General; Medical / Physicians