This book contains contributions from participants at a Porphyrin Photosensitization Workshop held in Washington DC on 28-29 September, 1981. There had been several prior such gatherings during 1979 and 1980, but the 1981 meeting was the most extensive to date with almost 200 attending. These periodic meetings are designed to enable workers in the field to exchange information and learn of recent develop- ments. The Workshop was supported by PHS grant CA 31188 awarded by the National Cancer Institute, DHHS. Additional funds from Coherent Inc. [Laser Division], Palo Alto, con- tributed to the success of this meeting as did the many ex- cellent presentations and discussions. Preparation of camera-ready copy from submitted manu- scripts was carried out via the Textedit computer program by Glenn Cummings, Amanda Cummings and David Kessel. Respon- sibility for final manuscript preparation rests with the editors. David Kessel Thomas J. Dougherty CONTENTS INTRODUCTION D. Kessel and T.J. Dougherty. . * * . * . * . * * 1 PHOTORADIATION THERAPY - CLINICAL AND DRUG ADVANCES 3 T.J. Dougherty, D.G. Boyle, K.R. Weishaupt, B.A. Henderson, W.R. Potter, D.A. Bellnier and K.E. Wityk INTRA-ABDOMINAL APPLICATIONS OF HEMATOPORPHYRIN 15 PHOTORADIATION THERAPY . * ...* . * * .

The use of porphyrins for localization and photodynamic therapy of neoplastic disease has been the topic of several international symposia, reviews and books during the preceeding five years. The literature on this topic has continued to grow, as have numbers of presentations at national and international meetings relating to photobiology, chemistry, and lasers. In this volume, it is the intention of the editor to provide both information on current research projects, and detailed methodology used in such investigations. A bibliography on the subjects of porphyrin localization and therapy is included. The manuscripts contained in this volume are based on reports given at a Porphyrin Photosensitization Workshop which was held in Philadel phia, July 6-7, 1984. This Workshop was supported by NIH grant CA 36746, together with funds from the Fogarty International Center. Authors were requested to update their contributions to provide a summary of progress to mid 1985. Manuscripts containing material not presented in Philadelphia are also included, notably a series of articles describ ing current clinical and pre-clinical results from China. Since the Philadelphia Workshop, a meeting was held in Alghero, Sardinia (May, 1985), and additional conferences are now being planned; this attests to the continued interest in photodynamic therapy involving porphyrin photo sensitization."

Lee and Watkinson's Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice. The series covers procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage, and ablation. Forthcoming are volumes on pediatric interventional radiology and neurointerventional radiology.

Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice.

Transcatheter Embolisation and Therapy approaches the procedure in two ways . Section I systematically describes the techniques of transcatheter embolization and addresses the issues surrounding embolization procedures. Section II presents specific organ systems and pathologies that undergo embolization therapy.

Dr. David Kessel is a Consultant Radiologist at the Leeds Teaching Hospitals, UK, and Dr. Charles Ray, Jr. is Professor of Radiology and Co-Director of Research at the University of Colorado Denver Health Sciences Center, USA.

The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts - Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.

What are the must-know aspects to preparing for and performing the most frequently requested diagnostic and therapeutic interventional procedures? Interventional Radiology: A Survival Guide, 4th Edition gives you the information you need to provide safe care in an easy-to-read, concise format. Written by experienced radiologists Drs. H. David Kessel and Iain Robertson, this edition features clear, step-by-step instructions for fundamental skills in this fast-growing field. Extensively restructured into 4 sections: Core interventional skills; Essential equipment; Principles of Vascular intervention and Principles of Non-vascular intervention. Increased emphasis on Interventional Oncology including the management of cancer and its complications. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. Nearly 300 line diagrams and photos illustrate procedures, including anatomical and technical points. Tip boxes highlight key facts and technical recommendations. Troubleshooting guides help get you back on track when things don't go exactly as planned. Warning boxes highlight common and important pitfalls.