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This book brings together the most important papers presented
during the 3rdInternational Congress on Neo-adjuvant Chemotherapy.
It offers a panoramic view of the international experience of
neo-adjuvant chemotherapy. In upper respiratory/gastrointestinal
tumours neo-adjuvant chemotherapy has an essential role in the
conservation of the larynx, and benefits regarding survival are
becoming apparent. In breast tumours it allows conservative
treatment in more than 80% of cases, with improved relapse-free
survival. In lung cancers, particularly epidermoid carcinomas,
intervention is possible in inoperable cases. Neo-adjuvant
chemotherapy assists local control measures and allows less
mutilating forms of treatment in oesophageal carcinomas and
generally in epidermoid carcinomas, particularly invasive tumours
of thehead and neck, the vulva and the anus. In bladder tumours
neo-adjuvant chemotherapy has an important role in local therapy.
In these fields research is aimed at improving the efficacy of
treatment while bypassing tumour resistance mechanisms. The methods
include metabolic manipulation (PFL), intensification of the doses,
the use of growth factors and autologous grafts, increasing the
concentration at the tumour site by intra-arterial injection (a
technique particularly used for gastrointestinal tumours), and
combining chemotherapy with biological response modifiers. All
these topics form the subject of chapters in this book, which
should direct the reader towards better and more effective
therapeutic strategies.
Imaging techniques are often called upon in oncology in virtue of
their essential role in tumor diagnosis, extension work up to
various organs and detection of relapse. They are also
indispensable in research and in clinical practice, allowing an
objective assessment of tumoral regression in patients undergoing
treatment. It is currently impossible to establish the management
plan of a cancer patient or to obtain follow-up of such a patient
under treatment without clinical and imaging confrontation.
David Khayat led France s war against cancer and has been in the
medical trenches for thirty years. In this international
bestseller, he shares his knowledge on the role of diet and
lifestyle in getting different types of cancer and how to bolster
the body against those risks. Bringing together his own
cross-national studies with those of other top cancer experts,
Khayat empowers readers with the latest nutritional knowledge. He
guides them through all food groups, including supplements and
beverages, often supplying surprising advice. For instance: eggs
are fine to eat and pomegranate juice is an amazing anticancer aid,
but men and premenopausal women should avoid carrot juice. Men and
women of all ages will find tips to meet their specific needs in
this accessible, user-friendly guide. Handy charts at the end of
the book distill information on the best and worst foods, habits,
and cooking methods for every body."
The subject of this book is the study of the relative roles of CT and MRI for all tumors; by contrast comparison with clinical results, the respective indications for these techniques are clarified, in term of diagnosis treatment planning and survey with educational presentation of radiologic signs.
This is the third volume of our series Progress in Anti-Cancer
Chemo therapy. Following the strategy of the first two volumes, it
covers selected aspects of progress in this fast moving field of
Oncology, with contribu tions from some of the world's best known
leaders in both basic and clin ical research. This year we focused
on seven areas: Three prominent Clinical investigators reviewed
conceptual advances in cancer research. Dr Buzdar presented a
history and overview of the protection of human subjects who
participate in clinical research, and the mechanisms developed to
assure the ethical conduct of research on human beings. Frei
reviewed an exciting and rapidly moving area of che motherapy of
solid tumors, including a cogent discussion of the issues related
to dose-intensification. Fisher summarized conceptual advances in
our therapeutic approach to breast cancer and the paradigm shifts
that lead us to our current management strategies. From this
summary he pro jected breast cancer research into the future, a
daunting task under any circumstance. Fundamental research in
cancer biology has been responsible for our improved understanding
of the development and progession of malignant disease. Such
understanding will lead to improved diagnosis, therapy, and
eventually, prevention. Isaacs reviews the area of hereditary
breast cancer, a topic undergoing rapid transformation and with
mUltiple impli cations in the daily practice of medicine. Fidler,
an international expert in metastasis research reviews the
potential utility of angiogenesis inhib itors in research and the
therapeutic ramifications."
This is the fourth volume of our series Progress in Anti-cancer
Therapy. For the past four years we have taken the challenge to
select each year, some of the most interesting topics on the wide
field of oncology. As usual, this volume continues the tradition
and covers five cancers (breast, prostate, bladder, lym phoma and
ovarian), the role of HIV and HTLV in cancer, as well as some deve
lopmental pharmacology and behavioral issues. This year, we have
particularly focused our attention on one of the most com mon
(although rarely addressed) cancer accounting for more than 315,00
newly diagnosed cases and 41,000 cancer-related deaths annually
(Landis SH et al., 1999): prostate cancer. Five chapters address
some of the issues concerning this disease. The chap ter by
Schroder describes the hopes and pitfalls of early detection of
prostate cancer. It reviews the literature on screening studies
that have been performed both in the US and in Europe. These
studies suggest that cancer mortality could be reduced by screening
for prostate cancer, mostly through PSA testing. However, the
effectiveness of early detection still needs to be definitely
confir med and ongoing randomized studies are described, the
results of which will probably help the medical community determine
the worth of PSA-based scree ning for prostate cancer. On the same
hand, the paper from von Eschenbach is reviewing the clinical
problems that are related this disease."
This book presents the Proceedings of the Second International
Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21
February 1988 in Paris.
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