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Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy (Paperback, 1991 ed.)
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Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy (Paperback, 1991 ed.)
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This book brings together the most important papers presented
during the 3rdInternational Congress on Neo-adjuvant Chemotherapy.
It offers a panoramic view of the international experience of
neo-adjuvant chemotherapy. In upper respiratory/gastrointestinal
tumours neo-adjuvant chemotherapy has an essential role in the
conservation of the larynx, and benefits regarding survival are
becoming apparent. In breast tumours it allows conservative
treatment in more than 80% of cases, with improved relapse-free
survival. In lung cancers, particularly epidermoid carcinomas,
intervention is possible in inoperable cases. Neo-adjuvant
chemotherapy assists local control measures and allows less
mutilating forms of treatment in oesophageal carcinomas and
generally in epidermoid carcinomas, particularly invasive tumours
of thehead and neck, the vulva and the anus. In bladder tumours
neo-adjuvant chemotherapy has an important role in local therapy.
In these fields research is aimed at improving the efficacy of
treatment while bypassing tumour resistance mechanisms. The methods
include metabolic manipulation (PFL), intensification of the doses,
the use of growth factors and autologous grafts, increasing the
concentration at the tumour site by intra-arterial injection (a
technique particularly used for gastrointestinal tumours), and
combining chemotherapy with biological response modifiers. All
these topics form the subject of chapters in this book, which
should direct the reader towards better and more effective
therapeutic strategies.
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