This is the first volume in a new series on 'Great Minds in Regional Science,' which seeks to present a contemporary view on the scientific relevance of the work done by great thinkers in regional science. It presents, among others, Walter Isard, Martin Beckmann and Gunnar Myrdal. Each contribution combines factual biographical information, a description of their major contributions, and a discussion of the broader context of the work, as well as an assessment of its current relevance, scientific recognition and policy impact. The book attempts to fill a gap in our knowledge, and to respond to the growing interest in the formation and development of the field of regional science and its key influential figures.

This book is the second volume in a new series on 'Great Minds in Regional Science,' which seeks to present a contemporary view on the scientific relevance of the work done by great thinkers in regional science. This volume presents, among others, Adam Smith, Johann Heinrich von Thunen, and Alan Wilson. Each chapter combines factual biographical information about the 'Great Mind,' a description of their major contributions, and a discussion of the broader context of their work, as well as an assessment of its current relevance, scientific recognition, and policy impact. The book attempts to fill a gap in our knowledge and to respond to the growing interest in the formation and development of the field of regional science and its key influential figures.

This is the first volume in a new series on 'Great Minds in Regional Science,' which seeks to present a contemporary view on the scientific relevance of the work done by great thinkers in regional science. It presents, among others, Walter Isard, Martin Beckmann and Gunnar Myrdal. Each contribution combines factual biographical information, a description of their major contributions, and a discussion of the broader context of the work, as well as an assessment of its current relevance, scientific recognition and policy impact. The book attempts to fill a gap in our knowledge, and to respond to the growing interest in the formation and development of the field of regional science and its key influential figures.

The p53 tumor suppressor gene--the "guardian of the genome"--protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of transcription factors (p53, p63, and p73) that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line. This collection also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.