This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.

Starting with the sinister rumblings of World War II in 1939 up to the jubilant celebration of its end in 1945 and the bitter aftermath, this sweeping saga recounts the experiences of Pawel, a Polish Jew from Krakow. Pawel and his family are the early victims of the ravages of war. He narrowly escapes the concentration camps to become a member of the French Resistance, before being rescued by the British and enlisted in the Royal Air Force. As the war escalates, Pawel and his fellow pilots engage in dangerous rescue missions and air combat across North Africa, Asia, the Mediterranean, Australia, and Europe, in a series of historic encounters that culminate in the Battle of Berlin. Against the background of death and destruction, Pawel fathers two children. His former Austrian fiance, Ada Eissmann, has spurned their love to return to her Nazi heritage, and has disowned their relationship and his paternity of the child she carries. After finding love again with Janelle and fathering her child, he is separated from her when they have to flee to safety to escape the Nazi death squads. Finding his love and his two children becomes a personal mission for him, representing hope and the chance for happiness after years of conflict, danger, deprivation and loss.

This book presents a study to determine the current limitations in the area of Photovoltaics (PV) as a source of renewable energy and proposes strategies to overcome them by applying optimization approaches in three main areas, namely related to photovoltaic solar cells, modules, and systems. These include grid metallization design of Si-based solar cells and modules; cost-effectiveness analysis between Si-based monofacial and bifacial grid-connected PV systems; optimal diesel replacement strategy for the progressive introduction of PV and batteries; dispatch strategy optimization for PV hybrid systems in real time. The novelty of the work presented in this book is of high interest to the scientific community but also to the PV manufacturers, installation companies, and investors.

This study examines Latino national political coalitions in the United States with a focus on Chicanos, Puerto Ricans, and Cubans. It argues that Latino national political coalitions are an avenue of political empowerment for the Latino Community, but face social, economic, and political challenges in the Latino community.

Recent debates about the Anthropocene have prompted a re-negotiation of the relationship between human subjectivity and nonhuman matter within a wide range of disciplines. This collection builds on the assumption that our understanding of the nonhuman world is bound up with the experience of space: thinking about and with nonhuman spaces destabilizes human-scale assumptions. Literary form affords this kind of nonanthropocentric experience; one role of the critic in the Anthropocene is to foreground the function of space and description in challenging the conventional link between narrative and human (inter)subjectivity. Bringing together New Formalism, ecocriticism, and narrative theory, the included essays demonstrate that literature can transgress the strong and long-established boundary of the human frame that literary and narrative scholarship clings to. The focus is firmly on the contemporary but with strategic samplings in earlier cultural texts (the American transcendentalists, modernist fiction) that anticipate present-day anxieties about the nonhuman, while at the same time offering important conceptual tools for working through them.

This book is the first green criminology text to focus specifically on Latin America. Green criminology has always adopted a broad horizon and explicitly emphasised that environmental crimes and harms affect countries and cultures around the world. The chapters collected here illuminate and describe the "theft of nature" and the "poisoning of the land" in Latin America through and from processes of agro-industry expansion, biopiracy, legal and illegal trafficking of free-born non-human animals, and mining. An interdisciplinary study, this collection draws on research from a wide range of international experts on not only green criminology, but also social justice, political ecology and sociology. An engaging and thought-provoking work, this book will be an essential text for anyone interested in current issues in environmental crime.

Readers encounter the environment through literature in ways not available to everyday perception. This is especially clear when a text integrates the grand vistas of what is known as the bird's-eye view. In this welcome contribution to the contemporary theoretical discussion about storied environments and non-human perceptions, David Rodriquez presents an original interpretation of the aesthetics of the view from above. Focusing on fiction by twentieth-century American writers including Willa Cather, Paul Bowles and Don DeLillo, Rodriguez skilfully combines ecocriticism, narrative theory and phenomenological approaches to literature to develop the term 'form of environment'. This theory of literary fiction foregrounds the environment not as setting or historical context, but as an equal agent with the human figures and scales that are normally the focus of literary analysis.

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

Hidden somewhere in South America, a world full of adventure awaits, but only the extravagant Professor Challenger believes in its existence. When he joins a reporter in search of adventure, a brave nobleman and a colleague ready to prove him wrong, Challenger will, at last, have the opportunity to discover the lost world.

This study examines Latino national political coalitions in the United States with a focus on Chicanos, Puerto Ricans, and Cubans. It argues that Latino national political coalitions are an avenue of political empowerment for the Latino Community, but face social, economic, and political challenges in the Latino community.

This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

This book approaches the problematic of social exclusion by way of the analysis of the symbiotic pair social exclusion/social inclusion. Its main concern is the problematisation of this pair in different contexts (both social, cultural and educational and at the local, national and supranational levels) through an analysis of five of the sites - body, work, citizenship, identity and territory - upon which social exclusion/inclusion makes its impact. Thus, an inductive approach to theories on social exclusion (and social inclusion) is developed through the study of their real effects on individuals, groups and society on the basis of three socio-cultural paradigms, namely, traditional societies, modern societies and emerging post-modern societies. Este livro aborda a problematica da exclusao social atraves da analise do par simbiotico exclusao social/inclusao social. A sua preocupacao central consiste na problematizacao desse par conceptual em diferentes contextos (sociais, culturais e educationais aos niveis local, nacional e supranacional) atraves de uma analise dos lugares - corpo, trabalho, cidadania, identidade e territorio - sobre os quais a exclusao social/inclusao social tem efectivos impactos. Assim, desenvolve-se, de forma indutiva, uma abordagem das teorias sobre a exclusao social (e, e claro, da inclusao social) atraves do estudo dos seus efeitos reais sobre os individuos, grupos e sociedade com base nos tres paradigmas socioculturais, quer dizer, o das sociedades tradicionais, o das sociedades modernas e o das emergentes sociedades pos-modernas.

The pressing nature of environmental threats, such as: climate change, land-grabbing, biopiracy, animal exploitation and human environmental victimisation, are pushing the entire world to seek alternatives to prevent environmental damage in every corner of the globe. Southern Green Criminology focuses on the threat the western world poses to the rest of the globe, and how Western imposed ideas of progress are damaging the planet, especially the southern hemisphere. In the past five years, the attention of green criminologists has been directed at the Global South as the geographical site that experiences the severest consequences of harmful environmental practices. Such criminological direction is aimed at combating the environmental harms that affect the geographical and the metaphorical Souths. The main topic of this book is the conflicts that arise in the interaction between human beings and our natural environment, seen from a Southern perspective with a focus on the victimisation of the South. This book is simultaneously a scientific and a political endeavour, and will prove invaluable to students, researchers and environmental enthusiasts alike.

This book presents a study to determine the current limitations in the area of Photovoltaics (PV) as a source of renewable energy and proposes strategies to overcome them by applying optimization approaches in three main areas, namely related to photovoltaic solar cells, modules, and systems. These include grid metallization design of Si-based solar cells and modules; cost-effectiveness analysis between Si-based monofacial and bifacial grid-connected PV systems; optimal diesel replacement strategy for the progressive introduction of PV and batteries; dispatch strategy optimization for PV hybrid systems in real time. The novelty of the work presented in this book is of high interest to the scientific community but also to the PV manufacturers, installation companies, and investors.

Read Write Inc. Phonics Book Bag Books are engaging texts to support children with additional reading practice outside the classroom. They have been specifically designed for children to take home after school, in order to share their reading journey and celebrate their achievements with parents and carers. The books are closely matched to the existing Read Write Inc. Phonics Storybooks to reinforce children's classroom learning of phonics at the appropriate level, helping them to make even faster progress in reading.