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Enzyme- and Transporter-Based Drug-Drug Interactions - Progress and Future Challenges (Hardcover, 2010 Ed.)
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Enzyme- and Transporter-Based Drug-Drug Interactions - Progress and Future Challenges (Hardcover, 2010 Ed.)
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Germination of the thought of "Enzymatic- and Transporter-Based
Drug-Drug Interactions: Progress and Future Challenges" Proceedings
came about as part of the annual meeting of The American
Association of Pharmaceutical Scientists (AAPS) that was held in
San Diego in November of 2007. The attendance of workshop by more
than 250 pharmaceutical scientists reflected the increased interest
in the area of drug-drug interactions (DDIs), the greater focus of
PhRMA, academia, and regulatory agencies, and the rapid pace of
growth in knowledge. One of the aims of the workshop was to address
the progress made in quantitatively predicting enzyme- and
transporter-based DDIs as well as highlighted areas where such
predictions are poor or areas that remain challenging for the
future. Because of the serious clinical implications, initiatives
have arisen from the FDA
(http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the
importance of enzyme- and transporter-based DDIs. During the past
ten to fifteen years, we have come to realize that transporters, in
addition to enzymes, play a vital role in drug elimination. Such
insight has been possible because of the continued growth in
PK-ADME
(pharmacokinetics-absorption-distribution-metabolism-excretion)
knowledge, fueled by further advances in molecular biology, greater
availability of human tissues, and the development of additional
and sophisticated model systems and sensitive assay methods for
studying drug metabolism and transport in vitro and in vivo. This
has sparked an in-depth probing into mechanisms surrounding DDIs,
resulting from ligand-induced changes in nuclear receptors, as well
as alterations in transporter and enzyme expression and function.
Despite such advances, the in vitro and in vivo study of drug
interactions and the integration of various data sets remain
challenging. Therefore, it has become apparent that a proceeding
that serves to encapsulate current strategies, approaches, methods
and applications is necessary. As Editors, we have assembled a
number of opinion leaders and asked them to contribute chapters
surrounding these issues. Many of these are the original Workshop
speakers whereas others had been selected specially to contribute
on topics related to basic and applied information that had not
been covered in other reference texts on DDI. The resulting tome,
entitled Enzyme- and Transporter-Based Drug Interactions: Progress
and Future Challenges, comprises of four sections. Twenty-eight
chapters covering various topics and perspectives related to the
subject of metabolic and transporter-based drug-drug interactions
are presented.
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