Locard’s Exchange Principle underpins all forensic science and holds that the perpetrator of a crime will bring something to the crime scene and leave with something from it.

Forensic experts use this principle daily to catch murderers and assailants. In Risking Life for Death, South African forensic pathologist Ryan Blumenthal offers a master class in this singular forensic technique based on real-life case studies. With more than twenty years’ experience in the field, Blumenthal explains how to look for clues and traces, and how what he does not find at autopsy is often more important than what he does find. In other words, the absence of evidence can sometimes be of greater value than the presence of evidence.

His account also highlights the dangers forensic pathologists are exposed to daily. As they try to unravel the puzzle of someone’s death, forensic pathologists often face life-threatening infections, toxic gases and the hazards associated with high-profile cases – in effect, risking their life to solve someone else’s death.

An understanding of Locard’s Exchange Principle can help you become a medical detective in your own life, can help you be a happier person and can even provide you with a better philosophy for growing older, Blumenthal argues.

The Fundamentals of Human Embryology covers embryonic development, with a unique focus on adult anatomy.

Its goal is to impart to students a comprehensive overview of how the human embryo forms, not only as a basis for the student of human anatomy, but also as a link to abnormalities they may encounter in their clinical careers. Extensively illustrated with labeled line drawings, now enlarged for better visibility, this concise manual will meet the needs of both undergraduate and postgraduate students in the Human Sciences.

In this Second Edition of the manual at the request of students and teachers, the authors have made the following changes:

• Increased the size of the diagrams
• Revised the text to comply with the Federative International Committee on Anatomical Terminology changes to the Terminologia Embryologica
• Altered the sequencing of some topics to allow the development to flow more logically
• Included an appendix of coloured photographs of congenital abnormalities to help students form a more realistic idea of developmental abnormalities.

As ’n eietydse mediese speurder het die forensiese patoloog Ryan Blumenthal al derduisende outopsies uitgevoer wat tot die arrestasie van ’n groot aantal misdadigers gelei het. Dit is sy groot doel en strewe om oortreders aan die pen te help ry.

In Outopsietafel beskryf hy van die moeilike lesse wat hy as ’n jong patoloog moes leer en hy vertel van die ongewone en dikwels grusame sterfgevalle wat hy al teëgekom het. Hy het gedurende sy loopbaan byvoorbeeld al etlike hoëprofielsterftes hanteer, sterftes weens natuurrampe en ook mense wat deur weerlig of wilde diere gedood is.

Blumenthal bied ’n fassinerende blik op alles wat agter die skerms gebeur by die lykshuis. Al kan die dooies nie praat nie, het hulle nogtans baie om te sê – en Blumenthal is daar om te luister.

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter.

Headache and Migraine in Practice provides practical and precise approaches to the headaches and facial pains commonly encountered in hospitals and clinics. The book pays specific attention to the clinical features of headaches to present treatment solutions, while also recommending ICHD3 differential diagnoses based on diagnostic criteria. Topics covered were developed by colleagues with expertise in Neurology, Nutrition, Psychiatry, Physical Medicine, and Sports Medicine, thus providing a collaborative authorship that adds interdisciplinary value. Sections cover the diagnosis and treatment of various types of headaches in children, the elderly and women during different periods of pregnancy, lactation and hormone-related stages. This book is recommended for general practitioners, internists, neurologists, headache nurse specialists, and all others who would like to contribute to better diagnoses and more effective treatment plans for patients with headaches and facial pains.

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan's 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women's healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.

Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism's physiology and survival.

According to the United Nations, the number of people aged 60 years or over in the world is projected to be 1.4 billion in 2030 and 2.1 billion in 2050. Endocrinologists and other clinicians face the challenge of caring for the elderly. To do so, they need to incorporate geriatric principles into their clinical practice. Endocrinology of Aging: Clinical Aspects in Diagrams and Images presents chapters in a way that allows the reader to incorporate concepts and main facts of complex subjects in a visual way. As the global population becomes older, the need for a deeper understanding of geriatric pathology increases, and with it, the access to educational resources for the endocrinology and metabolism of aging.

Clinical Molecular Medicine: Principles and Practice presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular basis of human disease. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances.

This volume comprises select proceedings of the International Conference on Humanizing Work and Work Environment organized by the Indian Society of Ergonomics (HWWE2019). The book presents research findings on different areas of ergonomics for developing appropriate tools and work environment considering capabilities and limitations of working people for maximum effectiveness on their performance. This volume will be of interest to academics, professionals and practitioners in the field of ergonomics.

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource.

Neuroepigenetics and Mental Illness, Volume 158, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series seeks to provide readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, with this release focusing on Neuroepigenetics in mental illness, Neuroepigenetics of development and neurodevelopmental disorder, Neuroepigenetics of aging and age-related neurodegenerative disorders, Neuroepigenetics of prenatal psychological stress, Neuroepigenetics of the HPA axis, Neuroepigenetics of the serotonergic system, and more.

Multiscale Biomechanics provides new insights on multiscale static and dynamic behavior of both soft and hard biological tissues, including bone, the intervertebral disk, biological membranes and tendons. The physiological aspects of bones and biological membranes are introduced, along with micromechanical models used to compute mechanical response. A modern account of continuum mechanics of growth and remodeling, generalized continuum models to capture internal lengths scales, and dedicated homogenization methods are provided to help the reader with the necessary theoretical foundations. Topics discussed include multiscale methods for fibrous media based on discrete homogenization, generalized continua constitutive models for bone, and a presentation of recent theoretical and numerical advances. In addition, a refresher on continuum mechanics and more advanced background related to differential geometry, configurational mechanics, mechanics of growth, thermodynamics of open systems and homogenization methods is given in separate chapters. Numerical aspects are treated in detail, and simulations are presented to illustrate models. This book is intended for graduate students and researchers in biomechanics interested in the latest research developments, as well as those who wish to gain insight into the field of biomechanics.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination is a concise guide to all currently known alcohol biomarkers, their clinical application, and the laboratory methods used to detect them. Pathologists can use this resource to understand the limitations and cost factors associated with each method for determining certain alcohol biomarkers. In addition, interferences in these determinations are discussed, so that clinicians can understand the causes of falsely elevated biomarkers and pathologists and laboratory scientists can potentially eliminate them. The book focuses on the analytical methods used to detect alcohol in blood and urine, the limitations of alcohol determination using enzymatic methods, and the differences between clinical and forensic alcohol measurement. Chapters also cover cutting-edge alcohol biomarkers for potential use.

ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

Essential Clinical Anatomy of the Nervous System is designed to combine the salient points of anatomy with typical pathologies affecting each of the major pathways that are directly applicable in the clinical environment. In addition, this book highlights the relevant clinical examinations to perform when examining a patient's neurological system, to demonstrate pathology of a certain pathway or tract. Essential Clinical Anatomy of the Nervous System enables the reader to easily access the key features of the anatomy of the brain and main pathways which are relevant at the bedside or clinic. It also highlights the typical pathologies and reasoning behind clinical findings to enable the reader to aid deduction of not only what is wrong with the patient, but where in the nervous system that the pathology is.

First developed as an accessible abridgement of the successful "Handbook of Stem Cells," "Essentials of Stem Cell Biology" serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to theapplication of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
Contributions by Nobel Laureates and leading international investigatorsIncludes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthroughEdited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debatePresented in full color with a glossary, highlighted terms, and bibliographic entries replacing references"

"Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation" provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.

Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.

These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.
Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedsideGuides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenariosCategorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications

Offering a study of biological, biomedical and biocultural approaches, the second edition of "Human Growth and Development "is a valued resource for researchers, professors and graduate students across the interdisciplinary area of human development. With timely chapters on obesity, diet / lifestyle, and genetics, this editionis the only publication offering a biological, biomedical and biocultural approach. The second edition of "Human Growth and Development" includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.
New chapters discussing genomics and epigenetics, developmental origins, body proportions and health and the brain and neurological development.Presented in the form of lectures to facilitate student programmingUpdated content highlighting the latest research on the relationship between early growth and later (adult) outcomes: the developmental origins of health and disease."

Primary immunodeficiency diseases, first recognized 60 years ago, are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies. This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases. With up-to-date diagnostic tools and therapeutic options - from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy - this volume will remain an authoritative resource on this increasingly important area.