While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers.

Exploring the potential of poetry and poetic language as a means of conveying perspectives on ageing and later life, this book examines questions such as 'how can we understand ageing and later life?' and 'how can we capture the ambiguities and complexities that the experiences of growing old in time and place entail?' As poetic language illuminates, transfigures and enchants our being in the world, it also offers insights into the existential questions that are amplified as we age, including the vulnerabilities and losses that humble us and connect us. Literary gerontology and narrative gerontology have highlighted the importance of linguistic representations of ageing. While the former has been concerned primarily with the analysis of published literary works, the latter has foregrounded the individual and collective meaning making through narrative resources in old age. There has, however, been less interest in how poetic language, both as a genre and as a practice, can illuminate ageing. This volume suggests a path towards the poetics of ageing by means of presenting analyses of published poetry on ageing written by poets from William Shakespeare to Wallace Stevens; the use of reading and writing poetry among ordinary people in old age; and the poetic nuances that emerge from other literary practices and contexts in relation to ageing - including personal poetic reflections from many of the contributing authors. The volume brings together international scholars from disciplinary backgrounds as diverse as cultural psychology, literary studies, theology, sociology, narrative medicine, cultural gerontology and narrative gerontology, and will deploy a variety of empirical and critical methodologies to explore how poetry and poetic language may challenge dominant discourses and illuminate alternative understandings of ageing.

Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.

Muscle Biology: The Life History of a Muscle looks at the story of a muscle from its embryonic beginnings, through its growth and ability to adapt to changing functional circumstances during adult life, to its eventual decline in both structure and function as old age progresses. Injury occurs to muscle during normal activity, after trauma, and during the source of certain diseases. Chapters on both muscle regeneration and muscle diseases emphasize the possibilities and limitsations of the healing capacity of muscle fibers. Muscle Biology begins with a brief review about the structure and function of a normal mature muscle and then proceeds to follow the developmental history of a muscle from the embryo to old age in a manner that gives the reader a perspective about not only developmental controls but also how at any stage of development a muscle is able to adapt to its functional environment. The book discusses both normal and abnormal changes in the muscle, the mechanisms behind those changes and how to mitigate deleterious changes from disease, 'normal' aging, and disuse/lack of physical activity. This is a must-have reference for students, researchers and practitioners in need of a comprehensive overview of muscle biology.

Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies covers the neuronal cell communication system in excitable cells, recognizing the most relevant mechanisms of cell communication. Along with new findings in biotechnology, medicine and pathological cases for clinicians, the book highlights electrochemical potential in living nerve and muscle cells. Written for physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists, this book an essential read for a real understanding of the signals as we see them.

Bioengineering is a rapidly expanding interdisciplinary field that encompasses application engineering techniques in the field of mechanical engineering, electrical, electronics and instrumentation engineering, and computer science and engineering to solve the problems of the biological world. With the advent to digital computers and rapidly developing computational techniques, computer simulations are widely used as a predictive tool to supplement the experimental techniques in engineering and technology. Computational biomechanics is a field where the movements biological systems are assessed in the light of computer algorithms describing solid and fluid mechanical principles. This book outlines recent developments in the field of computational biomechanics. It presents a series of computational techniques that are the backbone of the field that includes finite element analysis, multi-scale modelling, fluid-solid interaction, mesh-less techniques and topological optimization. It also presents a series of case studies highlighting applications of these techniques in different biological system and different case studies detailing the application of the principles described earlier and the outcomes. This book gives an overview of the current trends and future directions of research and development in the field of computational biomechanics. Overall, this book gives insight into the current trends of application of intelligent computational techniques used to analyse a multitude of phenomena the field of biomechanics. It elaborates a series of sophisticated techniques used for computer simulation in both solid mechanics, fluid mechanics and fluid-solid interface across different domain of biological world and across various dimensional scales along with relevant case studies. The book elucidates how human locomotion to bacterial swimming, blood flow to sports science, these wide range of phenomena can be analyzed using computational methods to understand their inherent mechanisms of work and predict the behavior of the system. The target audience of the book will be post-graduate students and researchers in the field of Biomedical Engineering. Also industry professionals in biomedical engineering and allied disciplines including but not limited to kinesiologists and clinicians, as well as, computer engineers and applied mathematicians working in algorithm development in biomechanics.

Progress in Genomic Medicine: From Research to Clinical Application provides a careful synthesis of the foundations, current trends and translational challenges in genomic medicine, clarifying pathways forward and enabling genomic medicine research and implementation across clinical settings and treatment development. Sections address the history and growth of genetic medicine, with a discussion of key studies in syndrome delineations, inherited diseases, biochemical genetics, and chromosome abnormalities, overview clinical applications made possible through genomic advances, with chapters on DNA sequencing for clinical genetic diagnosis, genotype-phenotype correlations in individuals and across populations, new-born screening for treatable genetic disorders, and more. In addition, social, ethical and public health aspects of applying genomic technologies are included throughout. Here, Dr. Smith applies her experience and participation in the field, across its major milestones, to put current research, clinical advances, and ongoing questions in context.

Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding.

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan's 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women's healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki's book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book.

Biology of Cardiovascular and Metabolic Diseases combines physiology and pathophysiology of selected metabolic and cardiovascular diseases with health relevance. Written in a concise and easy to read manner, the book allows readers to gain an understanding on a number of topics, including cardiovascular physiology and pathophysiology and how it relates to the development of insulin resistance, diabetes and other metabolic diseases. The book also highlights the relevance of obesity in the development of cardiovascular and metabolic diseases and emphasizes the benefits of exercise as a preventative measure and way to treat underlying conditions.

The Skeletal System, Second Edition is a modern update of the bestselling, classic The Skeletal System chart dating back to 1947. The illustrations are vividly colored and finely detailed, and structures are clearly labeled. The chart features three large illustrations showing the anterior, lateral, and posterior views of the skeletal system. Eight smaller illustrations show: Portion of Long Bone Auditory Ossicles (Left Medial View 3X) Ligaments of Right hand (Dorsal and Palmar Views) Ligaments of Right Foot (Dorsal and Plantar View) Right Knee Joint (Anterior and Posterior Views) 20" x 26" heavy paper laminated with grommets at top corners

Instructional technologies used to be optional and supplemental pedagogical tools until the global health crisis of 2020 compelled education systems to rely on digital devices and services to guarantee academic continuity. Suddenly, the contemporary principles and practices utilized in delivering health education curricula were insufficient and ineffective. Acknowledging the vital role of technology in shaping the future of education, there is now a greater demand to foster innovative interventions and continuous improvement in strategies, methodologies, and systems to empower learners, educators, and leaders in the digital age. Instructional Technologies in Health Education and Allied Disciplines provides comprehensive coverage of innovative methods and strategies to produce the next generation of health professionals. The book lays the groundwork for an implementable teaching and learning model that facilitates basic knowledge acquisition, enhances perceptual variation, improves skill coordination, and develops a scientific and technological mindset. Covering key topics such as gamification, telehealth, and robotics, this reference work is ideal for healthcare professionals, nurses, administrators, researchers, academicians, scholars, practitioners, instructors, and students.

Due to the current paradigm shift from traditional teaching to a mixed model with the inclusion of e-learning strategies, reforms in clinical education models are necessary and must carefully consider the socio-professional changes needed to support such efforts. Further study of the implementation of clinical and virtual reality education simulators in education, the irreplaceable role of teaching in the design of advanced roles for health professionals, and the role of education in the continuing professional development are all necessary for the future of successful allied health professional education. The Handbook of Research on Improving Allied Health Professions Education: Advancing Clinical Training and Interdisciplinary Translational Research discusses a range of important topics related to medical and health professions education and clarifies purposes, processes, and future priorities in introducing changes in the educational system. Covering topics such as new technologies and patient safety, this major reference work is ideal for researchers, practitioners, academicians, industry professionals, instructors, and students.

Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful.

John Rebus stands accused: on trial for a crime that could put him behind bars for the rest of his life. Although it's not the first time the legendary detective has taken the law into his own hands, it might be the last. What drove a good man to cross the line? Or have times changed, and the rules with them? Detective Inspector Siobhan Clarke faces Edinburgh's most explosive case in years, as a corrupt cop goes missing after claiming to harbour secrets that could sink the city's police force. But in this investigation, it seems all roads lead to Rebus - and Clarke's twin loyalties to the public and the police will be tested to their limit. A reckoning is coming - and John Rebus may be hearing the call for last orders...