Human Growth and Development, Third Edition provides a comprehensive volume covering the biology of human growth and the genetic, endocrine, environmental, nutritional, and socio-economic factors that contribute towards its full expression. Human Growth and Development continues to be a valuable resource for researchers, professors and graduate students across the interdisciplinary area of human development. For the new edition, updates are made to all fourteen of the "core chapters" of the book which form the essential reading for a comprehensive understanding of human growth and development. Additionally, new special topics are covered including the interpretation of recently found sub-adult fossils that expand our understanding of the evolution of human growth and a discussion of the early pattern of growth and development as the developmental origins of risk for non-communicable diseases of adulthood. Human Growth and Development, Third Edition includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Perinatal and Reproductive Genetics, Seventh Edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies in this growing field. The book is ideal for medical students, residents, physicians and researchers involved in the care of patients with genetic conditions. This comprehensive, yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. Chapters from leading international researchers and clinicians focus on topics ranging from single gene testing to whole genome sequencing, whole exome sequencing, gene therapy, genome editing approaches, FDA regulations on genomic testing and therapeutics, and ethical aspects of employing genomic technologies.

Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource.

"International Review of Research in Developmental Disabilities "is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences.

Volume 42 of the series offers chapters on a variety of themes.
Provides the most recent scholarly research in the study of developmental disabilitiesA vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Meet-the-Professor (MTP) Endocrine Case Management, Reference Edition 2018 is your source for the latest updates in the diagnosis and management of a wide range of endocrine disorders. This valuable resource allows you to evaluate your endocrine knowledge and gain insight into the strategies used by clinical experts. MTP is updated annually with new cases. Features include: Significance of the Clinical Problem. Key Learning Objectives. Strategies for Diagnosis and Management. Clinical Pearls and Pertinent References. Cases and Questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

Practical applications of physiology of exercise factual materials found in the Applied Physiology of Exercise textbook are of paramount importance to understand the principles of training. The Applied Physiology of Exercise Laboratory Manual complements the Applied Physiology of Exercise textbook where practical applications in both laboratory and field settings are shared. These practical applications are mostly through personal research at the Nanyang Technological University, National Institute of Education, and Human Bioenergetics Laboratory of Singapore. The uniqueness of the laboratory sessions found in the manual was attested to the many hours of hard laboratory research work. For example, the Running Energy Research Index (RERI) Laboratory was born as a result of a 10-year long research. This laboratory research work, like the other researched laboratory sessions in the manual, is then used in practical sessions in physiology of exercise classes to fine-tune the best possible learning experiences for students. After a long process of fine tuning and constructive feasibility, the laboratory sessions became concrete and designed specifically for this manual.

Practical applications of physiology of exercise factual materials found in the Applied Physiology of Exercise textbook are of paramount importance to understand the principles of training. The Applied Physiology of Exercise Laboratory Manual complements the Applied Physiology of Exercise textbook where practical applications in both laboratory and field settings are shared. These practical applications are mostly through personal research at the Nanyang Technological University, National Institute of Education, and Human Bioenergetics Laboratory of Singapore. The uniqueness of the laboratory sessions found in the manual was attested to the many hours of hard laboratory research work. For example, the Running Energy Research Index (RERI) Laboratory was born as a result of a 10-year long research. This laboratory research work, like the other researched laboratory sessions in the manual, is then used in practical sessions in physiology of exercise classes to fine-tune the best possible learning experiences for students. After a long process of fine tuning and constructive feasibility, the laboratory sessions became concrete and designed specifically for this manual.

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study.

Food and water are necessary for survival, but can only be obtained via ingestive behavior (feeding, drinking, and moving). Survival thus depends on the ability of the brain to coordinate the need for water and energy with appropriate behaviors to modify their intake as necessary for homeostasis. However, the balance of these behaviors also inherently determines body weight, and imbalances contribute to the development of weight disorders, such as obesity and anorexia nervosa. The lateral hypothalamic area (LHA) of the brain is anatomically positioned to coordinate the sensation of osmotic and energy status with goal-directed ingestive behaviors necessary to maintain homeostasis and body weight, and, hence, may hold insight into the potential treatment for energy balance disorders. This volume reviews the essential role of the LHA for the control of body weight, from its historical description as a ""feeding center"" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. Furthermore, we evaluate how specific LHA populations coordinate certain metabolic cues and behaviors, which may guide the development of pathway-specific interventions to improve the treatment of energy balance disorders.

This book is suitable for anyone interested in training with the use of science. Training has to be science-based and science is the only way forward, thus the book title indicates Applied Physiology of Exercise. Any training can be answered with physiological rationale. If it cannot be answered, people are moving away from specific intelligent training and into erroneous combination high-load training (for example, combining aerobic and anaerobic interval training in a single training session) that may not elicit a higher percentage of physiological adaptations but may induce injuries as the body is not conditioned properly. Combination high-level training may be introduced at a later stage once an individual goes through specific conditioning following a general conditioning of building the 'base' or 'foundation' period for at least six months. Factual training with science takes time to attain superior performance without performance-enhancing drugs or supplements such as growth hormones and testosterone. Gathering the 'right' knowledge is important and hopefully readers will be better equipped after reading this book. There are questions in each chapter to enhance learning and comprehension. It requires readers to think, rationalize, answer, and apply the facts to training or weight loss programs. These questions aim to ignite the critical component of learning as readers critique and re-analyze their training program. Even though each training could be different with everyone holding on to a different training philosophy, facts through science are universal for all.

This book is suitable for anyone interested in training with the use of science. Training has to be science-based and science is the only way forward, thus the book title indicates Applied Physiology of Exercise. Any training can be answered with physiological rationale. If it cannot be answered, people are moving away from specific intelligent training and into erroneous combination high-load training (for example, combining aerobic and anaerobic interval training in a single training session) that may not elicit a higher percentage of physiological adaptations but may induce injuries as the body is not conditioned properly. Combination high-level training may be introduced at a later stage once an individual goes through specific conditioning following a general conditioning of building the 'base' or 'foundation' period for at least six months. Factual training with science takes time to attain superior performance without performance-enhancing drugs or supplements such as growth hormones and testosterone. Gathering the 'right' knowledge is important and hopefully readers will be better equipped after reading this book. There are questions in each chapter to enhance learning and comprehension. It requires readers to think, rationalize, answer, and apply the facts to training or weight loss programs. These questions aim to ignite the critical component of learning as readers critique and re-analyze their training program. Even though each training could be different with everyone holding on to a different training philosophy, facts through science are universal for all.

Once thought uncommon, cases of Hashimoto's thyroiditis are becoming much more commonplace through the increasing use of needle biopsy and serologic tests for antibodies that have led to much more frequent recognition. It is currently one of the most common thyroid disorders with the possibility that it may be increasing in frequency. As diagnostic methods improve, it is imperative that quick treatments are administered to improve the quality of life of patients. Diagnosing and Managing Hashimoto's Disease: Emerging Research and Opportunities is an essential publication that provides critical reference material for diagnosing and treating Hashimoto's Disease in a clinical environment. Featuring research on topics such as spontaneous hypothyroidism, papillary thyroid carcinoma, and differential diagnosis, this publication is ideally designed for clinicians, therapists, doctors, nurses, hospital administrators, researchers, educators, academicians, and students looking for the most up-to-date research on treating Hashimoto's Disease.

Child development comprises children's cognitive, linguistic, motor, social and emotional development, communication, and self-care skills. Understanding developmental periods means that possible problems or roadblocks can be planned for or prevented. Knowledge of child development is necessary for achieving educational goals and is integral to promoting children's healthy and timely development. Global Perspectives on Prenatal, Postnatal, and Early Childhood Development is an essential scholarly reference source that compiles critical findings on children's growth periods and characteristics as well as the principles that affect their development. Covering a wide range of topics such as at-risk children, early intervention, and support programs, this book is ideally designed for child development specialists, pediatricians, educators, program developers, administrators, psychologists, researchers, academicians, and students. Additionally, the book provides insight and support to health professionals working in various disciplines in the field of child development and health.