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Books > Medicine > Pre-clinical medicine: basic sciences

Polycystic Kidney Disease (Hardcover): Christian Riella, Peter G Czarnecki, Theodore I Steinman Polycystic Kidney Disease (Hardcover)
Christian Riella, Peter G Czarnecki, Theodore I Steinman; Series edited by D. Neil Granger, Ph.D., Joey P. Granger, Ph.D.
R1,362 Discovery Miles 13 620 Ships in 18 - 22 working days

This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for 4.4% of end-stage renal disease (ESRD) cases in the U.S. Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments. Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved.

ESAP (TM) 2018: Endocrine Self-Assessment Program - Questions, Answers, Discussions, Reference Edition (Hardcover): Lisa R... ESAP (TM) 2018: Endocrine Self-Assessment Program - Questions, Answers, Discussions, Reference Edition (Hardcover)
Lisa R Tannock
R2,208 Discovery Miles 22 080 Ships in 18 - 22 working days

Endocrine Self-Assessment Program (ESAP (TM)), Reference Edition 2018 is a self-study curriculum for physicians and health professionals wanting a self assessment and a broad review of endocrinology. It consists of 120 brand-new multiple choice questions in all areas of endocrinology, diabetes, and metabolism. There is extensive discussion of each correct answer, a comprehensive syllabus, and references. ESAP is updated annually with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

Tempests, Poxes, Predators, and People - Stress in Wild Animals and How They Cope (Hardcover): L Michael Romero, John C.... Tempests, Poxes, Predators, and People - Stress in Wild Animals and How They Cope (Hardcover)
L Michael Romero, John C. Wingfield
R4,073 Discovery Miles 40 730 Ships in 10 - 15 working days

Although scientists have discovered many fundamental physiological and behavioral mechanisms that comprise the stress response, most of current knowledge is based on laboratory experiments using domesticated or captive animals. Scientists are only beginning, however, to understand how stress impacts wild animals - by studying the nature of the stressful stimuli that animals in their natural environments have adapted to for survival, and what the mechanisms that allow that survival might be. This book summarizes, for the first time, several decades of work on understanding stress in natural contexts. The aim is two-fold. The first goal of this work is to place modern stress research into an evolutionary context. The stress response clearly did not evolve to cause disease, so that studying how animals use the stress response to survive in the wild should provide insight into why mechanisms evolved the way that they did. The second goal is to provide predictions on how wild animals might cope with the Anthropocene, the current period of Earth's history characterized by the massive human remodeling of habitats on a global scale. Conservation of species will rely upon how wild animals use their stress response to successfully cope with human-created stressors.

Hot Topics in Endocrine and Endocrine-Related Diseases (Hardcover): Monica Fedele Hot Topics in Endocrine and Endocrine-Related Diseases (Hardcover)
Monica Fedele
R3,121 Discovery Miles 31 210 Ships in 18 - 22 working days
New Frontiers in Biochemistry (Hardcover): Oliver Stone New Frontiers in Biochemistry (Hardcover)
Oliver Stone
R2,302 R2,105 Discovery Miles 21 050 Save R197 (9%) Ships in 18 - 22 working days
Tissue Regeneration: Biological Theory, Modeling and Applications (Volume II) (Hardcover): Shay Fisher Tissue Regeneration: Biological Theory, Modeling and Applications (Volume II) (Hardcover)
Shay Fisher
R2,399 R2,190 Discovery Miles 21 900 Save R209 (9%) Ships in 18 - 22 working days
Teaching Hippocampal Anatomy (Hardcover): Edison Miyawaki Teaching Hippocampal Anatomy (Hardcover)
Edison Miyawaki
R558 R513 Discovery Miles 5 130 Save R45 (8%) Ships in 18 - 22 working days
Synapse Development and Maturation - Comprehensive Developmental Neuroscience (Hardcover, 2nd edition): Pasko Rakic, John... Synapse Development and Maturation - Comprehensive Developmental Neuroscience (Hardcover, 2nd edition)
Pasko Rakic, John Rubenstein, Bin Chen, Kenneth Y. Kwan
R5,026 Discovery Miles 50 260 Ships in 10 - 15 working days

Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns.

Transformative Curriculum Design in Health Sciences Education (Hardcover): Colleen Halupa Transformative Curriculum Design in Health Sciences Education (Hardcover)
Colleen Halupa
R5,368 Discovery Miles 53 680 Ships in 18 - 22 working days

A crucial element in ensuring patient safety and quality of care is the proper training of the next generation of doctors, nurses, and healthcare staff. To effectively serve their students, health science educators must first prepare themselves with competencies in pedagogy and curriculum design. Transformative Curriculum Design in Health Sciences Education provides information for faculty to learn how to translate technical competencies in medicine and healthcare into the development of both traditional and online learning environments. This book serves as a reference for health sciences undergraduate and graduate faculty interested in learning about the latest health sciences educational principles and curriculum design practices. This critical reference contains innovative chapters on transformative learning, curriculum design and development, the use of technology in healthcare training through hybrid and flipped classrooms, specific pedagogies, interprofessional education, and more.

Nucleic Acids Chemistry - Modifications and Conjugates for Biomedicine and Nanotechnology (Hardcover): Ramon Eritja Nucleic Acids Chemistry - Modifications and Conjugates for Biomedicine and Nanotechnology (Hardcover)
Ramon Eritja
R4,167 Discovery Miles 41 670 Ships in 10 - 15 working days

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Mechanisms of Hormone Action (Hardcover): Estelle Jones Mechanisms of Hormone Action (Hardcover)
Estelle Jones
R2,597 R2,365 Discovery Miles 23 650 Save R232 (9%) Ships in 18 - 22 working days
Genotoxicity and Mutagenicity - Mechanisms and Test Methods (Hardcover): Sonia Soloneski, Marcelo L. Larramendy Genotoxicity and Mutagenicity - Mechanisms and Test Methods (Hardcover)
Sonia Soloneski, Marcelo L. Larramendy
R3,072 Discovery Miles 30 720 Ships in 18 - 22 working days
Skin Aging Handbook - An Integrated Approach to Biochemistry and Product Development (Hardcover): Nava Dayan Skin Aging Handbook - An Integrated Approach to Biochemistry and Product Development (Hardcover)
Nava Dayan
R4,664 Discovery Miles 46 640 Ships in 10 - 15 working days

Anti-aging products are undergoing exceptional growth in the cosmetics industry far beyond that of general cosmetics. This book is the only available text that assembles the key pieces developers need to produce new breakthroughs for a growing market that demands quicker and more effective results. It also focuses much needed attention on the biochemical and clinical differences between Caucasian and other skin types.
Beginning with detailed descriptions of the forces driving the anti-aging market, this unique book provides readers with all the tools necessary to further research, develop, market, and sell novel products. Recent discoveries on the molecular level and novel methods of skin aging assessment are detailed as well as the state of the rapidly changing global regulatory environment. The formulation approaches of major cosmetics companies are presented as are their techniques for measuring skin aging in vitro and in vivo, both on the molecular and clinical levels.
Provides philosophical perspective on the growth of the anti-aging market
Covers skin types beyond Caucasian
Provides key pieces for developing and selling new breakthrough products
Includes technology from major cosmetic companies such as Chanel, Avon, Estee lauder and others"

Tissue Engineering, Therapy and Applications of Bone Regeneration (Hardcover): Shay Fisher Tissue Engineering, Therapy and Applications of Bone Regeneration (Hardcover)
Shay Fisher
R3,238 R2,928 Discovery Miles 29 280 Save R310 (10%) Ships in 18 - 22 working days
Family Planning and Reproductive Health (Hardcover): Zouhair Amarin, Hassan Abduljabbar Family Planning and Reproductive Health (Hardcover)
Zouhair Amarin, Hassan Abduljabbar
R3,057 Discovery Miles 30 570 Ships in 18 - 22 working days
Muscular Dystrophies (Hardcover): Kunihiro Sakuma Muscular Dystrophies (Hardcover)
Kunihiro Sakuma
R3,060 Discovery Miles 30 600 Ships in 18 - 22 working days
Evolutionary Genomics (Hardcover): Maria Anisimova Evolutionary Genomics (Hardcover)
Maria Anisimova
R2,103 Discovery Miles 21 030 Ships in 18 - 22 working days
Gestational Diabetes - Causes, Diagnosis and Treatment (Hardcover): Luis Sobrevia Gestational Diabetes - Causes, Diagnosis and Treatment (Hardcover)
Luis Sobrevia
R3,092 Discovery Miles 30 920 Ships in 18 - 22 working days
Genetics of Hearing Impairment (Hardcover): Ignacio del, Hannie Kremer Genetics of Hearing Impairment (Hardcover)
Ignacio del, Hannie Kremer
R2,207 R1,877 Discovery Miles 18 770 Save R330 (15%) Ships in 18 - 22 working days
100 Years of Human Chorionic Gonadotropin - Reviews and New Perspectives (Paperback): Laurence A. Cole, Stephen A. Butler 100 Years of Human Chorionic Gonadotropin - Reviews and New Perspectives (Paperback)
Laurence A. Cole, Stephen A. Butler
R2,552 Discovery Miles 25 520 Ships in 10 - 15 working days

100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

Thyroid Hormone (Hardcover): N K Agrawal Thyroid Hormone (Hardcover)
N K Agrawal
R3,609 Discovery Miles 36 090 Ships in 18 - 22 working days
Behavioral and Neural Genetics of Zebrafish (Hardcover): Robert T. Gerlai Behavioral and Neural Genetics of Zebrafish (Hardcover)
Robert T. Gerlai
R3,552 Discovery Miles 35 520 Ships in 10 - 15 working days

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions.

Gestational Diabetes (Hardcover): Miroslav Radenkovic Gestational Diabetes (Hardcover)
Miroslav Radenkovic
R3,607 Discovery Miles 36 070 Ships in 18 - 22 working days
The Cardiac Lymphatic System - An Overview (Hardcover, 2013 ed.): Ganga Karunamuni The Cardiac Lymphatic System - An Overview (Hardcover, 2013 ed.)
Ganga Karunamuni
R4,580 Discovery Miles 45 800 Ships in 10 - 15 working days

The heart is invested with a complex, intertwining network of blood and lymphatic vessels which, respectively, provide the cardiac tissue with oxygen and nutrients and eliminate excess fluid from the interstitium. The coronary blood vessels have been the focus of much investigation in the past few decades. On the other hand, the literature regarding the cardiac lymphatic vessels remains sparse, despite their important role in maintaining normal heart function. With this in mind, a better understanding of the cardiac lymphatic network and its ability to regulate fluid homeostasis within the heart could give us insight into developing therapies for the alleviation of several cardiac pathological conditions.

The Autumn Brain Seminars - Volume Two (Hardcover): Edison K Miyawaki The Autumn Brain Seminars - Volume Two (Hardcover)
Edison K Miyawaki
R931 Discovery Miles 9 310 Ships in 10 - 15 working days
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