100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

One of the biggest questions in today's biochemistry is how biological molecules became essential for the processes that occur within living cells. This new book from outstanding Metal Ions in Life Science series gives an overview about biochemical evolution of organic molecules and metabolic pathways in living systems and outlines the vital biochemical processes in microbial cells in which metals are involved.

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions.

This book deals with the way that the auditory system processes acoustic signals. The current edition has been revised in all areas to reflect the progress that has been made since the 3rd edition. As well as dealing with the basic anatomy and physiology of all stages of the auditory system, the book relates basic physiological processes to the performance of the auditory system as a whole, in the perception of acoustic signals including speech. The chapter on sensorineural hearing loss not only describes the physiological and anatomical changes that are associated with hearing loss, but includes latest information on treatments including cochlear implants, and work being undertaken on stem cell and other cellular therapies for deafness. A reading scheme has been provided to guide readers to the section most appropriate for their interests. The book is written so that those entering auditory research from very little background in auditory neuroscience are able to understand the current research issues and the current research literature. It is also intended to be a source book and reference work for advanced undergraduates studying the special senses, and for clinicians in the specialty of Otorhinolaryngology.

The heart is invested with a complex, intertwining network of blood and lymphatic vessels which, respectively, provide the cardiac tissue with oxygen and nutrients and eliminate excess fluid from the interstitium. The coronary blood vessels have been the focus of much investigation in the past few decades. On the other hand, the literature regarding the cardiac lymphatic vessels remains sparse, despite their important role in maintaining normal heart function. With this in mind, a better understanding of the cardiac lymphatic network and its ability to regulate fluid homeostasis within the heart could give us insight into developing therapies for the alleviation of several cardiac pathological conditions.

Known for its hallmark Clinical Blue Boxes, Moore's Essential Clinical Anatomy, 7th Edition, combines an easy-to-read approach, dynamic surface anatomy and medical imaging features, and engaging digital resources to build clinical confidence and equip users for success from foundational science courses through clinical training and practice. The concise, user-friendly format emphasizes structures and functions critical to physical diagnosis for primary care, interpretation of diagnostic imaging, and understanding the anatomical basis of emergency medicine and general surgery. This updated 7th Edition reflects the latest clinical perspectives and is supported by valuable self-assessment tools, case studies, and interactive BioDigital software to enrich understanding for students and practitioners alike. NEW! Sex and gender content clarifies important gender considerations and reflects an equitable focus on female as well as male anatomy. Extensively revised Clinical Blue Boxes highlight the practical applications of anatomy, accompanied by helpful icons, illustrations, and images that distinguish the type of clinical information covered. Revised comprehensive surface anatomy photographs ensure accurate, effective physical examination diagnoses with integrated natural views of unobstructed surface anatomy and illustrations superimposing anatomical structures with landmarks for more accurate physical examination. Insightfully rendered, anatomically accurate illustrations, combined with many photographs and medical images, strengthen comprehension of anatomical concepts and retention of "mental images" of anatomical structures. Medical Imaging sections familiarize students with plain and contrast radiographic, MRI, CT, and ultrasonography studies they'll use in clinical practice. Comprehensive tables clarify complex information about muscles, veins, arteries, nerves, and other structures for easy study and review.

From the gene that causes people to age prematurely to the "bitter gene" that may spawn broccoli haters, this book explores a few of the more exotic locales on the human genome, highlighting some of the tragic and bizarre ways our bodies go wrong when genes fall prey to mutation and the curious ways in which genes have evolved for our survival. Lisa Seachrist Chiu offers here a smorgasbord of stories about rare and not so rare genetic quirks-the gene that makes some people smell like a fish, the Black Urine Gene, the Werewolf Gene, the Calico Cat Gene. We read about the Dracula Gene, a mutation in zebra fish that causes blood cells to explode on contact with light, and suites of genes that also influence behavior and physical characteristics. The Tangier Island Gene, first discovered after physicians discovered a boy with orange tonsils (scientists now realize that the child's odd condition comes from an inability to process cholesterol). And Wilson's Disease, a gene defect that fails to clear copper from the body, which can trigger schizophrenia and other neurological symptoms, and can be fatal if left untreated. On the plus side, we read about the Myostatin gene, a mutation which allows muscles to become much larger than usual and enhances strength-indeed, the mutations have produced beefier cows and at least one stronger human. And there is also the much-envied Cheeseburger Gene, which allows a lucky few to eat virtually anything they want and remain razor thin. While fascinating us with stories of genetic peculiarities, Chiu also manages to explain much cutting-edge research in modern genetics, resulting in a book that is both informative and entertaining. It is a must read for everyone who loves popular science or is curious about the human body.

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.