|
|
Books > Medicine > Pre-clinical medicine: basic sciences
This volume of Progress in Molecular Biology and Translational
Science focuses on the growth hormone in health and disease.
Aging: From Fundamental Biology to Societal Impact examines the
interconnection of the cellular and molecular basis of aging and
societal-based challenges and innovative interventions. Sections
take a societal-based angle on aging, describing several flagship
initiatives for healthy living and active aging in different
regions, cover the biology of aging which includes the hallmarks of
aging, explain the pathophysiology of aging, describing different
comorbidities associated with aging and possible interventions to
decrease the impact of aging, and envision future and innovative
measures to tackle aging-related morbidities. Contributions from an
interdisciplinary panel of experts cover such topics as the biology
of aging to physical activity, nutrition, psychology, pharmacology,
health care, social care and urban planning.
Women and Positive Aging: An International Perspective presents the
noted research in the fields of psychology, gerontology, and gender
studies, reflecting the increasingly popular and pervasive positive
aging issues of women in today's society from different cohorts,
backgrounds, and life situations. Each section describes a bridge
between the theoretical aspects and practical applications of the
theory that is consistent with the scientist-practitioner training
model in psychology, including case studies and associated
intervention strategies with older women in each chapter. In
addition to incorporating current research on aging women's issues,
each section provides the reader with background about the topic to
give context and perspective.
Arrestins: Structure and Function in Vision and Beyond examines the
structural basis of the function of arrestin proteins in the brain.
Linking basic, translational and clinical research, this volume
begins with history and basic signaling principles and then expands
to the use of proteins as potential therapeutic targets. Multiple
cellular activities are detailed, including activation, signaling,
GPCR endocytosis, and ERK signaling, with chapters examining both
visual and non-visual arrestins. Experts in their respective fields
are featured throughout, making this book essential reading for
anyone who wants to explore the basic science underlying these
signaling proteins.
Molecules to Medicine with mTOR: Translating Critical Pathways into
Novel Therapeutic Strategies is a one-stop reference that
thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR,
also known as the mammalian target of rapamycin, is a 289-kDa
serine/threonine protein kinase that is ubiquitous throughout the
body and has a critical role in gene transcription and protein
formation, stem cell development, cell survival and senescence,
aging, immunity, tissue regeneration and repair, metabolism,
tumorigenesis, oxidative stress, and pathways of programmed cell
death that include apoptosis and autophagy. Incorporating a
translational medicine approach, this important reference
highlights the basic cellular biology of mTOR pathways, presents
the role of mTOR during normal physiologic function and disease,
and illustrates how the mechanisms of mTOR can be targeted for
current and future therapeutic treatment strategies. Coverage of
mTOR signaling includes the entire life cycle of cells that impacts
multiple systems of the body including those of nervous,
cardiovascular, immune, musculoskeletal, endocrine, reproductive,
renal, and respiratory origin.
Written by leaders in the field of chemosensation, Chemosensory
Transduction provides a comprehensive resource for understanding
the molecular mechanisms that allow animals to detect their
chemical world. The text focuses on mammals, but also includes
several chapters on chemosensory transduction mechanisms in lower
vertebrates and insects. This book examines transduction mechanisms
in the olfactory, taste, and somatosensory (chemesthetic) systems
as well as in a variety of internal sensors that are responsible
for homeostatic regulation of the body. Chapters cover such topics
as social odors in mammals, vertebrate and invertebrate olfactory
receptors, peptide signaling in taste and gut nutrient sensing.
Includes a foreword by preeminent olfactory scientist Stuart
Firestein, Chair of Columbia University's Department of Biological
Sciences in New York, NY. Chemosensory Transduction describes
state-of-the-art approaches and key findings related to the study
of the chemical senses. Thus, it serves as the go-to reference for
this subject for practicing scientists and students with
backgrounds in sensory biology and/or neurobiology. The volume will
also be valuable for industry researchers engaged in the design or
testing of flavors, fragrances, foods and/or pharmaceuticals.
Collaborative Genomics Projects: A Comprehensive Guide contains
operational procedures, policy considerations, and the many lessons
learned by The Cancer Genome Atlas Project. This book guides the
reader through methods in patient sample acquisition, the
establishment of data generation and analysis pipelines, data
storage and dissemination, quality control, auditing, and
reporting. This book is essential for those looking to set up or
collaborate within a large-scale genomics research project. All
authors are contributors to The Cancer Genome Atlas (TCGA) Program,
a NIH- funded effort to generate a comprehensive catalog of genomic
alterations in more than 35 cancer types. As the cost of genomic
sequencing is decreasing, more and more researchers are leveraging
genomic data to inform the biology of disease. The amount of
genomic data generated is growing exponentially, and protocols need
to be established for the long-term storage, dissemination, and
regulation of this data for research. The book's authors create a
complete handbook on the management of research projects involving
genomic data as learned through the evolution of the TCGA program,
a project that was primarily carried out in the US, but whose
impact and lessons learned can be applied to international
audiences.
Beauty, Aging and AntiAging covers novel and updated research and
treatment options regarding the effects of aging on human
physiology. Beauty perception and related molecular pathways are
reviewed, along with current medical and surgical approaches to
aging. The first part of the book focuses on beauty, youth, aging
and its effects on the human body. In the second part, various
restorative treatment approaches are reviewed in detail.
Particularly, invasive treatment options and molecular
pathophysiology of aging are covered in this book.
John Rebus stands accused: on trial for a crime that could put him
behind bars for the rest of his life. Although it's not the first
time the legendary detective has taken the law into his own hands,
it might be the last. What drove a good man to cross the line? Or
have times changed, and the rules with them? Detective Inspector
Siobhan Clarke faces Edinburgh's most explosive case in years, as a
corrupt cop goes missing after claiming to harbour secrets that
could sink the city's police force. But in this investigation, it
seems all roads lead to Rebus - and Clarke's twin loyalties to the
public and the police will be tested to their limit. A reckoning is
coming - and John Rebus may be hearing the call for last orders...
Metabolic Analysis Using Stable Isotopes, the newest volume in
Methods in Enzymology continues the legacy of this premier serial
with quality chapters authored by leaders in the field. This volume
covers research methods in metabolic analysis using stable
isotopes.
Regulatory T Cells in Health and Disease focuses on the mechanism
by which T cells become regulatory T cells, the processes which
control the number of regulatory T cells in the blood and tissue,
and the ways in which regulatory T cell prevent autoimmune disease
and interact with infections and cancer.
Renowned for its comprehensive coverage and engaging, storytelling
approach, the bestselling Moore's Clinically Oriented Anatomy, 9th
Edition, guides students from initial anatomy and foundational
science courses through clinical training and practice. A popular
resource for a variety of programs, this proven text serves as a
complete reference, emphasizing anatomy that is important in
physical diagnosis for primary care, interpretation of diagnostic
imaging, and understanding the anatomical basis of emergency
medicine and general surgery. The 9th Edition reflects the latest
changes in the clinical application of anatomy as well as
preparation for the USMLE while maintaining the highest standards
for scientific and clinical accuracy. NEW! Sex and gender content
clarifies important gender considerations and reflects an equitable
focus on female as well as male anatomy. Updated medical imaging
and integrated surface anatomy within each chapter clearly
demonstrates the relationship between anatomy, physical
examination, and diagnosis. Extensively revised Clinical Blue Boxes
highlight the practical applications of anatomy, accompanied by
helpful icons, illustrations, and images that distinguish the type
of clinical information covered. Updated introduction establishes
the foundational understanding of systemic information and basic
concepts essential to success from the classroom to the dissection
lab. Revised comprehensive surface anatomy photographs ensure
accurate, effective physical examination diagnoses with integrated
natural views of unobstructed surface anatomy and illustrations
superimposing anatomical structures with landmarks for more
accurate physical examination. Insightfully rendered, anatomically
accurate illustrations, combined with many photographs and medical
images, strengthen comprehension of anatomical concepts and
retention of "mental images" of anatomical structures. Bottom Line
boxes provide detailed summaries at a glance and underscore the
"big-picture" perspective. Illustrated tables clarify complex
information about muscles, veins, arteries, nerves, and other
structures for easy study and review. Chapter outlines help
students find key information quickly and efficiently.
Back to Basics in Physiology: O2 and CO2 in the Respiratory and
Cardiovascular Systems exploits the gap that exists in current
physiology books, tackling specific problems and evaluating their
repercussions on systemic physiology. It is part of a group of
books that seek to provide a bridge for the basic understanding of
science and its direct translation to the clinical setting, with a
final aim of helping readers further comprehend the basic science
behind clinical observations. The book is interspersed with
clinical correlates and key facts, as the authors believe that
highlighting direct patient care issues leads to improved
understanding and retention. Physiology students, including
graduate and undergraduate students, nursing students, physician
associate students, and medical students will find this to be a
great reference tool as part of an introductory course, or as
review material.
The field of genetics is rapidly evolving, and new medical
breakthroughs are occurring as a result of advances in our
knowledge of genetics. Advances in Genetics continually publishes
important reviews of the broadest interest to geneticists and their
colleagues in affiliated disciplines.
Meet-the-Professor (MTP) Endocrine Case Management, Reference
Edition 2019 is your source for the latest updates in the diagnosis
and management of a wide range of endocrine disorders. This
valuable resource allows you to evaluate your endocrine knowledge
and gain insight into the strategies used by clinical experts. MTP
is updated annually with new cases. Features include: Significance
of the Clinical Problem. Key Learning Objectives. Strategies for
Diagnosis and Management. Clinical Pearls and Pertinent References.
Cases and Questions. Customers are advised that this book is a
reference edition and the questions in it are designed for
self-study and reference. The content is the same as the
non-reference edition, but CME and MOC credits are not available
upon completion of the material. Anyone with questions about CME
and/or MOC credits should consult www.endocrine.org/store for
further information.
|
You may like...
Weighing Reasons
Errol Lord, Barry Maguire
Hardcover
R1,916
Discovery Miles 19 160
|