The riveting true story of John and Aileen Crowley's race to find a cure for Pompe disease that inspired the movie Extraordinary Measures

With three beautiful children, a new house, and financial security, John and Aileen Crowley were on top of the world--until their two youngest children, fifteen-month-old Megan and five-month-old Patrick, were diagnosed with Pompe disease and given only months to live. Refusing to accept a death sentence, John quit his financial consultant job and invested his life savings in a biotechnology start-up to research the disease and find a cure. Battling scientific setbacks, conflict of interest accusations, and business troubles, John and Aileen would be tested to their limits as they valiantly fought, and succeeded, in finding revolutionary new treatment for the disease--offering hope to Megan, Patrick, and the many children and families affected by Pompe disease around the world.

The inspiration for the captivating film Extraordinary Measures, starring Brendan Fraser and Harrison Ford, The Cure is a remarkable true story of cutting-edge science, business acumen and daring, and one family's indomitable spirit.

Maintaining physical and mental performance with a revolutionary diet that helps prevent age-related diseases. Sears explains that it is possible to reverse our 'biological' age (which is different to our 'chronological' age) if we look at our hormones and our diet. It is crucial to maintain the right balance of hormones in our bodies - ageing is not necessarily about the decreasing of certain hormones but rather how they effectively communicate with each other to maintain equilibrium. The Zone is a revolutionary diet plan which advocates a lower intake of carbohydrates which convert to sugar creating a diabetic-like condition. If we eat more protein and monosaturate fats we enter the Zone of optimum metabolic function. This diet has been proven in preventing age-related diseases: heart disease and diabetes (non-insulin dependent diabetes largely occurs in older age). Sears explores the activity of hormones as we age and gives a dietary plan (and supplement advice) to maintain peak performance: * calorie restriction without hunger or deprivation * insulin, cortisol, seratonin and eicosanoids * oestrogen and the menopause * testosterone as men and women age * DHEA, melatonin - are these hormonal supplements merely hype? * your thyroid gland and how it affects metabolism * exercise and the anti-ageing Zone lifestyle 'pyramid'

A must-have book for understanding one of the most fundamental areas of physical therapy: the nervous system and its relationship to musculoskeletal pain. Osteopath, lecturer and author John Gibbons offers an accessible introduction to the peripheral nervous system (PNS). Alongside real case studies and guidelines for hands-on work with clients and patients, The Vital Nerves demystifies and makes accessible everything from how to diagnose nerve conditions to understanding how our cells communicate. Gibbons provides critical insights into the structure and functions of the PNS; the body's response to stimuli and how it knows what to do; the sympathetic and parasympathetic nervous systems; understanding the stress response; and how reflex testing can aid in diagnosing conditions like Multiple Sclerosis, Parkinson's Disease, and paresthesias. The Vital Nerves addresses practical, common considerations like how to: Assess the nervous system using a patella (reflex) hammer, myotome (muscle) testing and dermatome (sensory) testing Determine whether pain in the posterior part of the thigh is caused by the sciatic nerve, piriformis or simply a hamstring strain Decide at what level a disc may have herniated Differentiate between upper and lower motor neurone disorders Know what to do with the findings of your neurological assessment and the circumstances under which to refer patients for more specialist care. The Vital Nerves is a comprehensive, must-have roadmap to the functional anatomy of the nervous system. Enriched with anatomical drawings and detailed explanations, it explains neurological testing, common neuropathies, and differential diagnoses, and is an indispensable resource for physical therapists and bodyworkers.

Instructional technologies used to be optional and supplemental pedagogical tools until the global health crisis of 2020 compelled education systems to rely on digital devices and services to guarantee academic continuity. Suddenly, the contemporary principles and practices utilized in delivering health education curricula were insufficient and ineffective. Acknowledging the vital role of technology in shaping the future of education, there is now a greater demand to foster innovative interventions and continuous improvement in strategies, methodologies, and systems to empower learners, educators, and leaders in the digital age. Instructional Technologies in Health Education and Allied Disciplines provides comprehensive coverage of innovative methods and strategies to produce the next generation of health professionals. The book lays the groundwork for an implementable teaching and learning model that facilitates basic knowledge acquisition, enhances perceptual variation, improves skill coordination, and develops a scientific and technological mindset. Covering key topics such as gamification, telehealth, and robotics, this reference work is ideal for healthcare professionals, nurses, administrators, researchers, academicians, scholars, practitioners, instructors, and students.

Due to the current paradigm shift from traditional teaching to a mixed model with the inclusion of e-learning strategies, reforms in clinical education models are necessary and must carefully consider the socio-professional changes needed to support such efforts. Further study of the implementation of clinical and virtual reality education simulators in education, the irreplaceable role of teaching in the design of advanced roles for health professionals, and the role of education in the continuing professional development are all necessary for the future of successful allied health professional education. The Handbook of Research on Improving Allied Health Professions Education: Advancing Clinical Training and Interdisciplinary Translational Research discusses a range of important topics related to medical and health professions education and clarifies purposes, processes, and future priorities in introducing changes in the educational system. Covering topics such as new technologies and patient safety, this major reference work is ideal for researchers, practitioners, academicians, industry professionals, instructors, and students.

Met lewensgetroue hoedefinisie-illustrasies bied hierdie publikasie ’n uitsonderlike blik op al die belangrikste liggaamsdele en -stelsels, van kroontjie tot kleintoontjie. Akkurate terminologie in Afrikaans en Engels, asook definisies en verhelderende teks stel lesers verder in staat om grondige kennis van die spesiale eienskappe en werking van die verskillende liggaamstelsels op te doen.

While telemedicine was not a new concept before the COVID-19 pandemic, it has certainly helped to propel telehealth as a popular solution and tool for patients to continue to use well after the impacts of COVID-19 have been felt. However, telehealth also provided solutions for health institutions faced with the challenge of preparing the next generation of medical professionals remotely. Telemedicine allowed medical educators to accompany students in their first encounters with patients and to simulate practical scenarios. Through the pandemic, educators have striven to be more creative and propose solutions to overcome adversities such as language barriers, access to technological infrastructure, and lack of legal framework. Advancing Health Education With Telemedicine discusses and presents alternatives on taking advantage of available technologies and infrastructure of telemedicine and e-health to advance health professionals' education. This need emerged amid the pandemic to provide patients and their families with support and guidance, but it also brought opportunities to students to continue their training and be involved in this once-in-a-lifetime experience. Covering topics such as disease-awareness campaigns, medical education, and online clinical simulation, this book serves as a dynamic resource for medical students, medical professionals, medical directors, educational software developers, researchers, communications experts, professors, and academicians.

Bioengineering is a rapidly expanding interdisciplinary field that encompasses application engineering techniques in the field of mechanical engineering, electrical, electronics and instrumentation engineering, and computer science and engineering to solve the problems of the biological world. With the advent to digital computers and rapidly developing computational techniques, computer simulations are widely used as a predictive tool to supplement the experimental techniques in engineering and technology. Computational biomechanics is a field where the movements biological systems are assessed in the light of computer algorithms describing solid and fluid mechanical principles. This book outlines recent developments in the field of computational biomechanics. It presents a series of computational techniques that are the backbone of the field that includes finite element analysis, multi-scale modelling, fluid-solid interaction, mesh-less techniques and topological optimization. It also presents a series of case studies highlighting applications of these techniques in different biological system and different case studies detailing the application of the principles described earlier and the outcomes. This book gives an overview of the current trends and future directions of research and development in the field of computational biomechanics. Overall, this book gives insight into the current trends of application of intelligent computational techniques used to analyse a multitude of phenomena the field of biomechanics. It elaborates a series of sophisticated techniques used for computer simulation in both solid mechanics, fluid mechanics and fluid-solid interface across different domain of biological world and across various dimensional scales along with relevant case studies. The book elucidates how human locomotion to bacterial swimming, blood flow to sports science, these wide range of phenomena can be analyzed using computational methods to understand their inherent mechanisms of work and predict the behavior of the system. The target audience of the book will be post-graduate students and researchers in the field of Biomedical Engineering. Also industry professionals in biomedical engineering and allied disciplines including but not limited to kinesiologists and clinicians, as well as, computer engineers and applied mathematicians working in algorithm development in biomechanics.

A successful Wall Street trader turned neuroscientist reveals how risk taking and stress transform our body chemistry
Before he became a world-class scientist, John Coates ran a derivatives trading desk in New York City. He used the expression "the hour between dog and wolf" to refer to the moment of Jekyll-and-Hyde transformation traders passed through when under pressure. They became cocky and irrationally risk-seeking when on a winning streak, tentative and risk-averse when cowering from losses. In a series of groundbreaking experiments, Coates identified a feedback loop between testosterone and success--one that can cloud men's judgment in high-pressure decision-making. Coates demonstrates how our bodies produce the fabled gut feelings we so often rely on, how stress in the workplace can impair our judgment and even damage our health, and how sports science can help us toughen our bodies against the ravages of stress. Revealing the biology behind bubbles and crashes, "The Hour Between Dog and Wolf "sheds new and surprising light on issues that affect us all.

Today, there is a significant need for healthcare professionals across disciplines and sectors as the world faces unprecedented health challenges and adopts innovative healthcare technologies. Despite this demand for a competent and eager healthcare workforce, the education and processes to becoming a qualified healthcare professional are complex and intricate, which may turn people away from this path due to confusion, fear, or doubt. In order to encourage and support those involved in medical education, further study on the best practices and challenges of developing confident and capable health professionals is required. The Handbook of Research on Developing Competencies for Pre-Health Professional Students, Advisors, and Programs provides insight into the critical skills and expertise essential for those interested in pursuing employment in healthcare as well as current procedures and training to support them during their academic and professional careers. Covering topics such as lifelong learning skills, healthcare professions, and strategic learning, this major reference work is crucial for advisors, nurses, healthcare professionals, academicians, researchers, practitioners, scholars, instructors, and students.