Ernest Starling (1866-1927) was pre-eminent in the golden age of British Physiology. His name is usually associated with his ???Law of the Heart, ??? but his discovery of secretin (the first hormone whose mode of action was explained) and his work on capillaries were more important contributions. He coined the word 'hormone' one hundred years ago. His analysis of capillary function demonstrated that equal and opposite forces move across the capillary wall--an outward (hydrostatic) force and an inward (osmotic) force derived from plasma proteins.
Starling??'s contributions include:
*Developing the "Frank-Starling Law of the Heart," presented in 1915 and modified in 1919.
*The Starling equation, describing fluid shifts in the body (1896)
*The discovery of secretin, the first hormone, with Bayliss (1902) and the introduction of the concept of hormones (1905).

This textbook provides a thorough and comprehensive overview of the human brain and spinal cord for medical and graduate students as well as residents in the clinical neurosciences. Standing on the shoulders of training from outstanding scientist-teacher mentors and based on more than 30 years of experience teaching about the brain and spinal cord to medical and graduate students, this single authored text presents everything the reader would need as they begin their study of the nervous system. At the same time the experienced neuroscientist will find much useful and valuable information in these pages that is based almost exclusively on studies in experimental primates and observations in humans. Every effort has been made to present the complexities of the nervous system as simply and clearly as possible. The careful reader will discover a clarity and depth of coverage that makes the reading both instructional and enjoyable. Topics are presented logically and the text in an easy-to-read style. The accompanying line drawings emphasize important concepts in a clear and uncluttered manner.
Topics presented:
- Neurons, glial cells, degeneration, regeneration, axonal transport
- Review of the development of the human nervous system
- Overview of the anatomy of the spinal cord, brain stem and forebrain
- General sensory paths (pain, temperature, touch, pressure, proprioception)
- Special sensory systems (auditory, vestibular, visual, olfactory and gustatory)
- Eye movements and visual reflexes
- Comprehensive presentation of the regions involved in motor activity including the clinical manifestation of injuries to these motor areas
- Limbic system, hypothalamusand the autonomic nervous system
- Lobes of the brain, clinically important cortical areas and the results of lesions in these areas
- Blood supply to the spinal cord, brain stem, and brain including classical brain stem syndromes
- The meninges and the ventricular system
- Numerous helpful clinical correlations that emphasize the practical application of basic anatomical information.
* Presents the complexities of the nervous system as simply and clearly as possible
* Written with a clarity and depth of coverage that makes the reading both instructional and enjoyable
* Includes numerous illustrations emphasizing important concepts

International Review of Cytology presents current advances and comprehensive reviews in cell biology - both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Adhesion Molecules and Other Secreted Host-interaction Determinants in Apicomplexa: Insights from Comparative Genomics; Cell Responses to Biomimetic Protein Scaffold Used in Tissue Repair and Engineering; New Insights into Glycosphingolipid Function - Storage, Lipid Rafts and Translocators; Microscopic Morphology and the Origins of the Membrane Maturation Model of Golgi Apparatus Function; New Insights into the Macronuclear Development in Cilliates; Polarity Regulators and the Control of Epithelial Architecture, Cell Migration and Tumourigenesis.

The Atlas of X-Linked Intellectual Disability Syndromes is a comprehensive and up-to-date summary of the clinically distinctive disorders caused by genes on the X chromosome. Clinical and laboratory data on 150 syndromes are presented in a concise and consistent manner. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. Individual syndrome entries are supplemented with nineteen appendices that identify syndromes with common features and provide the location or mapping limits and function of the responsible genes. The authors have extensive experience in the clinical and laboratory delineation of X-linked intellectual disability. They have described new syndromes, regionally mapped disease loci on the X chromosome, and identified the genes responsible for X-linked syndromes.

The new edition of this infertility manual has been fully revised to provide clinicians with the latest advances in the diagnosis and management of infertility. Divided into seven sections, the book provides step by step guidance on each stage of the process, from initial examination and identifying the causes of infertility in both females and males, to ovarian stimulation and assisted reproduction techniques. The final section is dedicated to laboratory management covering topics such as follicular fluid screening and oocyte assessment, culture systems, and cryopreservation. The fourth edition includes new chapters on molecular mechanisms such as endometrial receptivity, and implantation; and current trends such as the embryoscope and assisted hatching. The comprehensive text is further enhanced by case studies, clinical photographs, diagrams, flowcharts and tables. Key points Fully revised, new edition providing latest advances in diagnosis and management of infertility Fourth edition features new chapters on molecular mechanisms and current trends Highly illustrated with clinical images, flowcharts and tables Previous edition (9788184486179) published in 2009

Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.

Genetics is in all senses a family affair. The diagnosis of a genetic condition affects not only the patient and biological family members who may themselves be at risk, but also "family" more generally as support may be sought from those considered kin and who may or may not be at risk themselves. It is considered best practice in genetic consultations to explore who will be informed within the family when a genetic condition or risk is diagnosed, particularly when the health of other family members is at risk. There is little guidance or consensus on how to achieve the implicit goal of informed family members while respecting patient confidentiality, however. There is a need for practitioners to be aware of the dynamics of family communication and to have guidance about how they may sensitively facilitate communication about genetics within families.
This handbook facilitates the development of clinical practices relating to family communication about genetics. Relevant theories of family communication are summarized and related to a clinical genetics milieu and, from this, frameworks for practitioners are presented. A book of this nature is particularly timely as the completion of the Human Genome Project will result in an unprecedented amount of information about genetic constitution and health risks becoming available to individuals and their families. The presence of a potential genetic condition in a family is not a new phenomenon. However, the growth in testing for genetic conditions, common complex conditions and variants that may influence health as well as drug metabolism means that a greater number of individuals will face decisions about communicating this information to their relatives. Many health professionals in all levels of health care will be confronted with issues of responsibility and practice in family communication about genetic information as they become providers of this testing.

The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therapeutics are fully covered in these volumes.

Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems.
Key Features
* Comprehensive treatment of a topical research field
* Authored by world leaders in the field
* Covers structural biology and physiology
* Covers different experimental and biological systems
* Chapters on plant and microbial systems
* Extensive treatment of mammalian physiology and pathophysiology
* Structural analysis excellently illustrated

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested

Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace.
With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

First FRCR Anatomy: Practice Cases offers the most up-to-date and comprehensive coverage of practice cases for trainees preparing for the First FRCR Anatomy exam. Chapters are mapped to the syllabus to deliver structured revision in all the key topics, allowing trainees to focus on areas of weakness. Featuring a wealth of practice cases, this book provides the essential revision tool to maximise chances Key Points 240 high quality images, reflecting the breadth of topics encountered in the actual exam Includes practical advice on how to approach revision and useful tips to improve exam technique Visually-enhanced answers improve understanding of key concepts Covers all imaging modalities, including plain x-rays, CT, MRI and ultrasound Complements First FRCR Anatomy: Mock Papers - the complete Anatomy revision package

Intrauterine insemination (IUI), also known as artificial insemination, is a fertility treatment that uses a catheter to place washed sperm directly into the uterus. Its aim is to increase the number of sperm reaching the fallopian tubes and subsequently increase the chances of fertilisation (American Pregnancy Association). This book is a step-by-step guide to intrauterine insemination (IUI). Divided into 12 sections, the text begins with detail on counselling, diagnostic work up, and indications of IUI. The following chapters cover ultrasound monitoring of an ART cycle, stimulation protocol, triggering ovulation, and when and how to administer IUI. The book concludes with discussion on complications of IUI, factors affecting success, and sperm preparation. Authored by recognised experts in the field, the text is further enhanced by colour photographs, illustrations and flowcharts. Key points Step-by-step guide to intrauterine insemination (IUI) Covers the complete ART cycle, from initial counselling and work up, to monitoring and procedures, to success factors and complications Highly illustrated with photographs, diagrams and flowcharts Recognised, expert author team

How women can improve their productivity, happiness, and physical well-being by keeping their natural cycles in mind and working with them (rather than ignoring them). In the Flo teaches women how to use their 28-day cycle to optimize their life by letting their internal clock and natural rhythms guide time management, diet, fitness, etc. (This is so simple and yet under-utilized it is shocking. It makes perfect sense when you think about it: You have different energy levels at different times of the month, different libido levels, etc. so why not use foresight to plan projects for when you are at your most effective, and understand when you need more emotional connection with others?) There are specific tips on what to eat and how to exercise depending on what phase you are in-and it works. Women are getting promotions, losing weight, and in one case thus far, literally clearing their endometriosis by using the cycle syncing method.

Test yourself on over 1,400 anatomical identifications. This 6-page guide is loaded with beautifully illustrated diagrams with blank labels for a true test of your knowledge. The Anatomy Test guide is a companion to our Anatomy guide which contains all the illustrations identified with the body parts name. ?PLEASE NOTE: You must purchase the Anatomy guide to receive the answers to the Anatomy Test guide.

Anatomy and Physiology is a complex subject spanning many health science disciplines. Principles of Anatomy and Physiology has always been recognized for its pioneering homeostatic approach to learning the subject.

This International Adaptation of the 16th edition combines exceptional content and outstanding visuals for a rich and comprehensive classroom experience and continues to set the standard for the discipline. It has been paired with a comprehensive Study Guide, offering a thoughtfully designed course in Anatomy and Physiology.

Highly regarded authors, Jerry Tortora and Bryan Derrickson motivate and support learners at every level, from novice to expert, and equip them with the skills they need to succeed in this class and beyond.

What’s new?:

• Packaged as a set, comprising the textbook and single-colour study guide
• The study guide is designed to reinforce the learning from the textbook and build relevance to the concepts studied. It comprises:Chapter Review and features such as Clinical Connection, Disorders, and Medical Terminology; Self-Quiz questions (with solutions); Solutions to Figure Questions

Eureka: Biochemistry & Metabolism is an innovative book for medical students that fully integrates core science, clinical medicine and surgery. The book benefits from an engaging and authoritative text, written by specialists in the field, and has several key features to help you really understand the subject: Chapter starter questions - to get you thinking about the topic before you start reading Break out boxes which contain essential key knowledge Clinical cases to help you understand the material in a clinical context Unique graphic narratives which are especially useful for visual learners End of chapter answers to the starter questions A final self-assessment chapter of Single Best Answers to really help test and reinforce your knowledge The book starts with a First Principles chapter which clearly explains the key concepts and mechanisms relevant to the study of medicine e.g. types of biochemical reaction, enzymes and cofactors. This is followed by a series of systems-based chapters which are introduced with an engaging clinical case which helps link the subject to the practice of medicine. Finally there is a self-assessment chapter consisting of 80 single best answer questions to test your understanding. The Eureka series of books are designed to be a 'one stop shop': they contain all the key information you need to know to succeed in your studies and pass your exams.

Revised and updated: a user-friendly illustrated guide to human anatomy, written for students and practitioners This concise, pocket-sized guide is a full-color, on-the-go reference for students and practitioners of anatomy, massage, physical therapy, chiropractics, medicine, nursing, and physiotherapy. The Pocket Atlas of Human Anatomy, revised edition, interweaves text and images in a user-friendly and accessible way. Images have been critically assessed and modified from the previous edition for a highly reliable learning tool of bones, muscles, and nerves, plus all the other major body systems. A final chapter by Thomas W. Myers outlines The Anatomy Trains myofascial meridians, which presents a map of how tracks of fascial fabric wind longitudinally through series of muscles. This new approach to structural patterning has far-reaching implications for effective movement training and manual therapy treatment. Three appendices illustrate cutaneous nerve supply and dermatomes (Appendix 1), the major skeletal muscles, including detailed charts of the main muscles involved in movement (Appendix 2), and the remaining body systems (Appendix 3).

What is the central sulcus within the brain? What do sebaceous glands secrete? These questions as well as many more are answered through the com-prehensive lists of anatomical terms and their defini-tions found within our latest 6 page study guide. The guide s easy-to-use format includes sections on each area of the human body and its accompanying terms; every word list is alphabetized so that users can find what they need quickly. Additionally, the guide is a great companion to our Anatomy QuickStudy(r) guide. Any medical student, doctor, or nurse should have this handy reference tool in his or her bookshelf

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Learn about the many things humans can do to get warm when they are too cold. Created in collaboration with the Smithsonian Institution, this STEAM book will ignite a curiosity about STEAM topics through real-world examples. It features a hands-on STEAM challenge that is perfect for makerspaces and that guides students step-by-step through the engineering design process. Make STEAM career connections with career advice from actual Smithsonian employees working in STEAM fields. Introduce early science topics to young readers with this STEAM book that is ideal for 1st grade students or ages 5-7.