These proceedings of the 2018 XIII International Symposium on Spermatology focus on comparative biology, and encourages discussion and the exchange of ideas. The aim of this Symposium was to provide a unique opportunity and bring together scientists from a wide spectrum of research fields - human, domestic animals and other mammals, vertebrates, insects, and plants. The underlying focus is on the function of the spermatozoon - a common feature for sexual reproduction, but extremely varied. By exploring the variability, a better understanding of male reproductive functions can develop. These proceedings address the mechanisms of physiology and pathophysiology, rather than diagnosis and treatment. The symposium featured keynote lectures by invited speakers, followed by presentations on specific aspects of the general topic of the session. Experimental studies are given priority over clinical studies of patient populations. The proceedings comprise both keynote speakers' texts and selected free communications. Posters were considered for publication in the proceedings, and the volume includes exhibited materials on the work of prominent spermatologists, highlighting their important past achievements in the field.

This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.

In this issue of Endocrinology and Metabolism Clinics, Guest Editor Pauline Camacho brings her considerable expertise to the topic of Osteoporosis. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field.

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

"The Path from Biomarker Discovery to Regulatory Qualification "is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science.

For complimentary access to chapter 13, "'""Classic' Biomarkers of Liver Injury, " by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site: http: //tinyurl.com/ClassicBiomarkers
Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science

Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use

Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities. "

Effectively manage reproductive endocrinology issues with Reproductive Endocrinology, a new book derived from the highly acclaimed two-volume textbook, Endocrinology: Adult and Pediatric. Never before available as a stand-alone offering, this compilation of chapters will enable you to give your patients the benefit of today's best know-how from the leading resource in endocrinology. Stay abreast of the newest knowledge in reproductive endocrinology, including. endocrinology of sexual behavior and gender identity genetic pathways that control gonadal development and sex differentiation management of PCOS and hirsutism, male androgen deficiency, and gynecomastia and much more. Effectively review the causes and management of precocious or delayed puberty. Count on all the authority that has made Endocrinology, 6th Edition, edited by leading endocrinologists Drs. Jameson and De Groot, the go-to clinical medical reference for endocrinologists worldwide. Make the best clinical decisions in reproductive endocrinology with an enhanced emphasis on evidence-based practice in conjunction with expert opinion.

Effectively manage parathyroid and bone metabolism disorders with The Parathyroid Gland and Bone Metabolism! Brought to you by the same leading endocrinologists responsible for the highly acclaimed two-volume textbook, Endocrinology: Adult and Pediatric, this derivative book presents a compilation of chapters covering all endocrinology material related to parathyroid and bone metabolism. Never before available as a stand-alone offering, this content will enable you to give your patients the benefit of today's best know-how on parathyroid and bone metabolism from the leading resource in endocrinology. Stay abreast of the newest knowledge and advances on parathyroid and bone metabolism, including. pediatric parathyroid disorders and bone metabolism disorders major diseases common to the aging population such as osteoporosis advances in the genetics of disorders involving calciotropic hormones newer diagnostic approaches and therapies for bone diseases, from osteoporosis to Paget's disease and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and De Groot, the go-to clinical medical reference for endocrinologists worldwide. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion.

Meet-the-Professor (MTP) Endocrine Case Management, Reference Edition 2018 is your source for the latest updates in the diagnosis and management of a wide range of endocrine disorders. This valuable resource allows you to evaluate your endocrine knowledge and gain insight into the strategies used by clinical experts. MTP is updated annually with new cases. Features include: Significance of the Clinical Problem. Key Learning Objectives. Strategies for Diagnosis and Management. Clinical Pearls and Pertinent References. Cases and Questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource.

This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as "collagenopathies" that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.

Child development comprises children's cognitive, linguistic, motor, social and emotional development, communication, and self-care skills. Understanding developmental periods means that possible problems or roadblocks can be planned for or prevented. Knowledge of child development is necessary for achieving educational goals and is integral to promoting children's healthy and timely development. Global Perspectives on Prenatal, Postnatal, and Early Childhood Development is an essential scholarly reference source that compiles critical findings on children's growth periods and characteristics as well as the principles that affect their development. Covering a wide range of topics such as at-risk children, early intervention, and support programs, this book is ideally designed for child development specialists, pediatricians, educators, program developers, administrators, psychologists, researchers, academicians, and students. Additionally, the book provides insight and support to health professionals working in various disciplines in the field of child development and health.

This original six chapter book will briefly review and integrate the basic concepts behind water distribution and movement in the body. This fills a knowledge gap that most medical and undergraduate physiology students acquire when these topics are studied separately. As of now, there is no textbook that fully integrates renal, cardiovascular and water physiology in a clear understandable manner. The book is intended primarily for medical students and undergraduate physiology students. Chapters include: 1) Water and its Distribution; 2) Water Dynamics; 3) Fluid Handling by the Heart and Blood Vessels; 4) Fluid Handling by the Kidneys; 5) Water and Oxygen Delivery; 6) Integration in the Response to Hemorrhage, Volume Depletion, and Water Redistribution.
An easy-to-read, step by step explanation of how water is distributed, how it moves, how this aides in oxygen delivery and how this is regulated in the human body.

Presentsa complex and detailed topicin an original way that will allow students to understand more complex textbooks and explanations"

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Once thought uncommon, cases of Hashimoto's thyroiditis are becoming much more commonplace through the increasing use of needle biopsy and serologic tests for antibodies that have led to much more frequent recognition. It is currently one of the most common thyroid disorders with the possibility that it may be increasing in frequency. As diagnostic methods improve, it is imperative that quick treatments are administered to improve the quality of life of patients. Diagnosing and Managing Hashimoto's Disease: Emerging Research and Opportunities is an essential publication that provides critical reference material for diagnosing and treating Hashimoto's Disease in a clinical environment. Featuring research on topics such as spontaneous hypothyroidism, papillary thyroid carcinoma, and differential diagnosis, this publication is ideally designed for clinicians, therapists, doctors, nurses, hospital administrators, researchers, educators, academicians, and students looking for the most up-to-date research on treating Hashimoto's Disease.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

This edited collection focuses on performance practice and analysis that engages with medical and biomedical sciences. After locating the 'biologization' of theatre at the turn of the twentieth century, it examines a range of contemporary practices that respond to understandings of the human body as revealed by biomedical science. In bringing together a variety of analytical perspectives, the book draws on scholars, scientists, artists and practices that are at the forefront of current creative, scientific and academic research. Its exploration of the dynamics and exchange between performance and medicine will stimulate a widening of the debate around key issues such as subjectivity, patient narratives, identity, embodiment, agency, medical ethics, health and illness. In focusing on an interdisciplinary understanding of performance, the book examines the potential of performance and theatre to intervene in, shape, inform and extend vital debates around biomedical knowledge and practice in the contemporary moment.

Food and water are necessary for survival, but can only be obtained via ingestive behavior (feeding, drinking, and moving). Survival thus depends on the ability of the brain to coordinate the need for water and energy with appropriate behaviors to modify their intake as necessary for homeostasis. However, the balance of these behaviors also inherently determines body weight, and imbalances contribute to the development of weight disorders, such as obesity and anorexia nervosa. The lateral hypothalamic area (LHA) of the brain is anatomically positioned to coordinate the sensation of osmotic and energy status with goal-directed ingestive behaviors necessary to maintain homeostasis and body weight, and, hence, may hold insight into the potential treatment for energy balance disorders. This volume reviews the essential role of the LHA for the control of body weight, from its historical description as a ""feeding center"" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. Furthermore, we evaluate how specific LHA populations coordinate certain metabolic cues and behaviors, which may guide the development of pathway-specific interventions to improve the treatment of energy balance disorders.

"International Review of Research in Developmental Disabilities "is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences.

Volume 42 of the series offers chapters on a variety of themes.
Provides the most recent scholarly research in the study of developmental disabilitiesA vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers