In Elegant Anatomy Marieke Hendriksen offers an account of the material culture of the eighteenth-century Leiden anatomical collections, which have not been studied in detail before. The author introduces the novel analytical concept of aesthesis, as these historical medical collections may seem strange, and undeniably have a morbid aesthetic, yet are neither curiosities nor art. As this book deals with issues related to the keeping and displaying of historical human remains, it is highly relevant for material culture and museum studies, cultural history, the history of scientific collections and the history of medicine alike. Unlike existing literature on historical anatomical collections, this book takes the objects in the collections as its starting point, instead of the people that created them.

Evolutionary science teaches that humans arose as a population, sharing common ancestors with other animals. Most readers of the book of Genesis in the past understood all humans descended from Adam and Eve, a couple specially created by God. These two teachings seem contradictory, but is that necessarily so? In the fractured conversation of human origins, can new insight guide us to solid ground in both science and theology? In The Genealogical Adam and Eve, S. Joshua Swamidass tests a scientific hypothesis: What if the traditional account is somehow true, with the origins of Adam and Eve taking place alongside evolution? Building on well-established but overlooked science, Swamidass explains how it's possible for Adam and Eve to be rightly identified as the ancestors of everyone. His analysis opens up new possibilities for understanding Adam and Eve, consistent both with current scientific consensus and with traditional readings of Scripture. These new possibilities open a conversation about what it means to be human. In this book, Swamidass untangles several misunderstandings about the words human and ancestry, in both science and theology explains how genetic and genealogical ancestry are different, and how universal genealogical ancestry creates a new opportunity for rapprochement explores implications of genealogical ancestry for the theology of the image of God, the fall, and people "outside the garden" Some think Adam and Eve are a myth. Some think evolution is a myth. Either way, the best available science opens up space to engage larger questions together. In this bold exploration, Swamidass charts a new way forward for peace between mainstream science and the Christian faith.

Although the phenomenon of lateral gene transfer has been known since the 1940's, it was the genomics era that has really revealed the extent and many facets of this evolutionary/genetic phenomenon. Even in the early 2000s with but a handful of genomes available it became clear that the nature of microorganisms is full of genetic exchange between lineages that are sometimes far apart. The years following this saw an explosion of genomic data, which shook the "tree of life" and also raised doubts about the most appropriate species concepts for prokaryotes. This book attempts to represent the many-fold contributions of LGT to the evolution of micro and, to an extent, macro-organisms by focusing on the areas where the Editor felt it had the largest impact: metabolic innovations and adaptations and speciation.

This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for 4.4% of end-stage renal disease (ESRD) cases in the U.S. Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments. Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved.

Endocrine Self-Assessment Program (ESAP (TM)), Reference Edition 2018 is a self-study curriculum for physicians and health professionals wanting a self assessment and a broad review of endocrinology. It consists of 120 brand-new multiple choice questions in all areas of endocrinology, diabetes, and metabolism. There is extensive discussion of each correct answer, a comprehensive syllabus, and references. ESAP is updated annually with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

Although scientists have discovered many fundamental physiological and behavioral mechanisms that comprise the stress response, most of current knowledge is based on laboratory experiments using domesticated or captive animals. Scientists are only beginning, however, to understand how stress impacts wild animals - by studying the nature of the stressful stimuli that animals in their natural environments have adapted to for survival, and what the mechanisms that allow that survival might be. This book summarizes, for the first time, several decades of work on understanding stress in natural contexts. The aim is two-fold. The first goal of this work is to place modern stress research into an evolutionary context. The stress response clearly did not evolve to cause disease, so that studying how animals use the stress response to survive in the wild should provide insight into why mechanisms evolved the way that they did. The second goal is to provide predictions on how wild animals might cope with the Anthropocene, the current period of Earth's history characterized by the massive human remodeling of habitats on a global scale. Conservation of species will rely upon how wild animals use their stress response to successfully cope with human-created stressors.

Pediatric arrhythmias present numerous challenges to pediatric cardiologists and other practitioners who see pediatric patients, including pediatricians, family physicians, emergency physicians, residents, fellows, and other clinicians. Arrhythmias in Children: A Case-Based Approach features practical methods for diagnosing and treating arrhythmias in these patients across all settings. Nearly three dozen real-world scenarios are presented, followed by a discussion of the diagnosis, clinical thinking process involved, treatment options, expected outcomes, and how to manage anticipated and unanticipated outcomes. These practical, realistic cases provide a unique and engaging way of approaching these challenging patient scenarios. Uses a case-based approach for a full spectrum of pediatric arrythmias in the newborn, child, pre-teen, and teenager. Presents history and physical, differential diagnoses, tests to order, and practical plans of action. Includes a section on arrythmias in special circumstances. Models clinical thinking skills for a wide number of real-world patient situations. Reviews pertinent clinical guidelines, treatment, and follow up.

The treatment of cancer in young women and men is increasingly turning from focusing purely on survival to a recognition of the long-term effects of treatment on subsequent quality of life. In this regard, fertility is a very high priority for patients. This is the first book to explain the latest techniques in fertility preservation. Chapters cover fertility preservation in both women and men, management of cancer in pregnancy, egg donation and surrogacy, hormone replacement options, counselling and ethical issues. A multidisciplinary team of over 60 specialists were involved in this work, with contributions from leading obstetricians, medical oncologists, gynaecological oncologists, urologists and fertility specialists. The book is formally supported by the Association of Cancer Physicians (ACP). This highly patient-centred, readable text will be of value to a wide range of clinicians and physicians, and doctors in training, in their daily work.

Epigenetics is the study of changes in gene expression caused by mechanisms other than changes in the DNA sequence. Epigenetics is a rapidly advancing field with an increasing impact on biological and medical research. The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics, and related fields. Topics include: early life environment * DNA methylation and behavior * histone acetyltransferase biology * transgenerational epigenetic inheritance * mammalian X inactivation * epigenetic memory in plants * polycomb-group regulation * centromeres and telomeres * DNA sequence contribution to nucleosome distribution * macrosatellite epigenetics * histones * cell-fate specification and reprogramming * DNA methylation in cancer * variant histone H2A and cancer development * RNA modification * paramutation in plants * DNMT3L dependent methylation during gametogenesis * non-coding RNA * bisulphite-enabled technologies * rapid analysis of DNA methylation * microarray mapping * DNA methylation profiling * ChIP-sequencing * genome-wide DNA methylation analysis * epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines. It represents a major information resource on the fascinating and fast-moving field of epigenetics.

Reinforce your knowledge of physiology with this active, engaging, and relaxing review method! Netter's Physiology Coloring Book makes abstract concepts more concrete as you use color and tactile movement to reinforce your memory and understanding of challenging topics. It's a fun and interactive way to learn and review a complex but fascinating subject-whether you're taking a physiology course or lab, or preparing for a career in science or medicine and healthcare.More than "just" a coloring book, this unique learning tool offers: More than 100 key topics in physiology, using bold, clear drawings based on classic artwork by Frank Netter, MD and other master scientific and medical illustrators. Coloring exercises that emphasize pathways, processes, and cycles for a visual memory aid. Quick-reference tables and Pathophysiology Notes that bridge basic science with health care and medicine. Workbook review questions and drawing challenges to reinforce comprehension and retention. Enhanced eBook version included with purchase. Your enhanced eBook includes completed coloring and workbook pages for reference and allows you to access all of the text and figures, from the book on a variety of devices.

Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns.

A crucial element in ensuring patient safety and quality of care is the proper training of the next generation of doctors, nurses, and healthcare staff. To effectively serve their students, health science educators must first prepare themselves with competencies in pedagogy and curriculum design. Transformative Curriculum Design in Health Sciences Education provides information for faculty to learn how to translate technical competencies in medicine and healthcare into the development of both traditional and online learning environments. This book serves as a reference for health sciences undergraduate and graduate faculty interested in learning about the latest health sciences educational principles and curriculum design practices. This critical reference contains innovative chapters on transformative learning, curriculum design and development, the use of technology in healthcare training through hybrid and flipped classrooms, specific pedagogies, interprofessional education, and more.

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

An AGI Brain for a Robot is the first and only book to give a detailed account and practical demonstration of an Artificial General Intelligence (AGI). The brain is to be implemented in fast parallel hardware and embodied in the head of a robot moving in the real world. Associative learning is shown to be a powerful technique for novelty seeking, language learning, and planning. This book is for neuroscientists, robot designers, psychologists, philosophers and anyone curious about the evolution of the human brain and its specialized functions. The overarching message of this book is that an AGI, as the brain of a robot, is within our grasp and would work like our own brains. The featured brain, called PP, is not a computer program. Instead, PP is a collection of networks of associations built from J. A. Fodor's modules and the author's groups. The associations are acquired by intimate interaction between PP in its robot body and the real world. Simulations of PP in one of two robots in a simple world demonstrate PP learning from the second robot, which is under human control. "Both Professor Daniel C. Dennett and Professor Michael A. Arbib independently likened the book 'An AGI Brain for a Robot' to Valentino Braitenberg's 1984 book 'Vehicles: Experiments in Synthetic Psychology'." Daniel C. Dennett, Professor of Philosophy and Director of Center for Cognitive Studies, Tufts University. Author of "From Bacteria to Bach and Back: The Evolution of Minds." "Michael Arbib, a long time expert in brain modeling, observed that sometimes a small book can catch the interest of readers where a large book can overwhelm and turn them away. He noted, in particular, the success of Valentino Braitenberg's 'Vehicles' (for which he wrote the foreword). At a time of explosive interest in AI, he suggests that PP and its antics may be just the right way to ease a larger audience into thinking about the technicalities of creating general artificial intelligence." Michael A Arbib, Professor Emeritus of Computer Science, Biomedical Engineering, Biological Sciences and Psychology, University of Southern California. Author of "How the Brain Got Language". "Robots seem to increasingly invade our lives, to the point that sometimes seems threatening and other-worldly. In this small book, John Andreae shows some of the basic principles of robotics in ways that are entertaining and easily understood, and touch on some of the basic questions of how the mind works." Michael C. Corballis, Professor of Psychology, University of Auckland. Author of "The Recursive Mind". "A little book that punches far beyond its weight." Nicholas Humphrey, Emeritus Professor of Psychology, London School of Economics. Author of "Soul Dust: The Magic of Consciousness". "A bold and rich approach to one of the major challenges for neuroscience, robotics and philosophy. Who will take up Andreae's challenge and implement his model?" Matthew Cobb, Professor of Zoology, University of Manchester. Author of "The Idea of the Brain". "Here is a book that could change the direction of research into artificial general intelligence in a very productive and profitable way. It describes a radical new theory of the brain that goes some way towards answering many difficult questions concerning learning, planning, language, and even consciousness. Almost incredibly, the theory is operational, and expressed in a form that could-and should-inspire future, novel, research in AI that transcends existing paradigms." Ian H. Witten, Professor of Computer Science, Waikato University. Author with Eibe Frank of "Data Mining: Practical Machine Learning Tools and Techniques".

A critical analysis of white, working class North Americans' motivations and experiences when traveling to Central Europe for donor egg IVF Each year, more and more Americans travel out of the country seeking low cost medical treatments abroad, including fertility treatments such as in vitro fertilization (IVF). As the lower middle classes of the United States have been priced out of an expensive privatized "baby business," the Czech Republic has emerged as a central hub of fertility tourism, offering a plentitude of blonde-haired, blue-eyed egg donors at a fraction of the price. Fertility Holidays presents a critical analysis of white, working class North Americans' motivations and experiences when traveling to Central Europe for donor egg IVF. Within this diaspora, patients become consumers, urged on by the representation of a white Europe and an empathetic health care system, which seems nonexistent at home. As the volume traces these American fertility journeys halfway around the world, it uncovers layers of contradiction embedded in global reproductive medicine. Speier reveals the extent to which reproductive travel heightens the hope ingrained in reproductive technologies, especially when the procedures are framed as "holidays." The pitch of combining a vacation with their treatment promises couples a stress-free IVF cycle; yet, in truth, they may become tangled in fraught situations as they endure an emotionally wrought cycle of IVF in a strange place. Offering an intimate, first-hand account of North Americans' journeys to the Czech Republic for IVF, Fertility Holidays exposes reproductive travel as a form of consumption which is motivated by complex layers of desire for white babies, a European vacation, better health care, and technological success.

Anti-aging products are undergoing exceptional growth in the cosmetics industry far beyond that of general cosmetics. This book is the only available text that assembles the key pieces developers need to produce new breakthroughs for a growing market that demands quicker and more effective results. It also focuses much needed attention on the biochemical and clinical differences between Caucasian and other skin types.
Beginning with detailed descriptions of the forces driving the anti-aging market, this unique book provides readers with all the tools necessary to further research, develop, market, and sell novel products. Recent discoveries on the molecular level and novel methods of skin aging assessment are detailed as well as the state of the rapidly changing global regulatory environment. The formulation approaches of major cosmetics companies are presented as are their techniques for measuring skin aging in vitro and in vivo, both on the molecular and clinical levels.
Provides philosophical perspective on the growth of the anti-aging market
Covers skin types beyond Caucasian
Provides key pieces for developing and selling new breakthrough products
Includes technology from major cosmetic companies such as Chanel, Avon, Estee lauder and others"