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Books > Medicine > Pre-clinical medicine: basic sciences

Enzymology at the Membrane Interface: Interfacial Enzymology and Protein-Membrane Binding, Volume 583 (Hardcover): Michael H.... Enzymology at the Membrane Interface: Interfacial Enzymology and Protein-Membrane Binding, Volume 583 (Hardcover)
Michael H. Gelb
R4,810 Discovery Miles 48 100 Ships in 12 - 19 working days

Enzymology at the Membrane Interface, the latest volume in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes.

Lipid Peroxidation: Current Topics (Hardcover): Donna Thompson Lipid Peroxidation: Current Topics (Hardcover)
Donna Thompson
R2,732 R2,484 Discovery Miles 24 840 Save R248 (9%) Ships in 10 - 15 working days
Chromothripsis - Methods and Protocols (Hardcover, 1st ed. 2018): Franck Pellestor Chromothripsis - Methods and Protocols (Hardcover, 1st ed. 2018)
Franck Pellestor
R5,205 Discovery Miles 52 050 Ships in 12 - 19 working days

This detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the in vitro investigation of chromothripsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chromothripsis: Methods and Protocols serves as a vital resource for cell biologists, molecular biologists, cytogeneticists, and geneticists investigating chromothripsis, but also for students and researchers new to the field of chromothripsis and genomic instability.

Fast Detection of DNA Damage - Methods and Protocols (Hardcover, 1st ed. 2017): Vladimir V. Didenko Fast Detection of DNA Damage - Methods and Protocols (Hardcover, 1st ed. 2017)
Vladimir V. Didenko
R4,990 Discovery Miles 49 900 Ships in 12 - 19 working days

This volume presents a comprehensive collection of quick assays for the detection of nuclear and mitochondrial DNA damage and its effects in live and fixed cells and tissues, and in bacterial genomes. Although, such rapid techniques are in demand in the "research trenches" they are not covered well in the literature. This volume is the first such compendium of the time-saving techniques for detection of DNA damage and its direct physiological outcomes including apoptosis, necrosis and phagocytic clearance. The volume demonstrates all levels of detection, starting from the molecular level up to the level of the entire live organism. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Fast Detection of DNA Damage: Methods and Protocols aims to provide easily reproducible techniques requiring only few steps to perform.

Alkaloids, Part 2 (Hardcover): Jiaju Zhou Alkaloids, Part 2 (Hardcover)
Jiaju Zhou
R6,628 Discovery Miles 66 280 Ships in 12 - 19 working days

This 8-volume set provides a systematic description on 8,350 active marine natural products from 3,025 various kinds of marine organisms. The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with 264 structural types are developed. The 4th volume continuously illustrates the molecular formula and structures of alkaloids.

Glutathione in Plant Growth, Development, and Stress Tolerance (Hardcover, 1st ed. 2017): Mohammad Anwar Hossain, Mohammad... Glutathione in Plant Growth, Development, and Stress Tolerance (Hardcover, 1st ed. 2017)
Mohammad Anwar Hossain, Mohammad Golam Mostofa, Pedro Diaz Vivancos, David J Burritt, Masayuki Fujita, …
R5,489 R5,142 Discovery Miles 51 420 Save R347 (6%) Ships in 12 - 19 working days

Glutathione ( -glutamyl-cysteinyl-glycine) is a ubiquitously distributed sulfurcontaining antioxidant molecule that plays key roles in the regulation of plant growth, development, and abiotic and biotic stress tolerance. It is one of the most powerful low-molecular-weight thiols, which rapidly accumulates in plant cells under stress. Recent in-depth studies on glutathione homeostasis (biosynthesis, degradation, compartmentalization, transport, and redox turnover) and the roles of glutathione in cell proliferation and environmental stress tolerance have provided new insights for plant biologists to conduct research aimed at deciphering the mechanisms associated with glutathione-mediated plant growth and stress responses, as well as to develop stress-tolerant crop plants. Glutathione has also been suggested to be a potential regulator of epigenetic modifications, playing important roles in the regulation of genes involved in the responses of plants to changing environments. The dynamic relationship between reduced glutathione (GSH) and reactive oxygen species (ROS) has been well documented, and glutathione has been shown to participate in several cell signaling and metabolic processes, involving the synthesis of protein, the transport of amino acids, DNA repair, the control of cell division, and programmed cell death. Two genes, gamma-glutamylcysteine synthetase (GSH1) and glutathione synthetase (GSH2), are involved in GSH synthesis, and genetic manipulation of these genes can modulate cellular glutathione levels. Any fluctuations in cellular GSH and oxidized glutathione (GSSG) levels have profound effects on plant growth and development, as glutathione is associated with the regulation of the cell cycle, redox signaling, enzymatic activities, defense gene expression, systemic acquired resistance, xenobiotic detoxification, and biological nitrogen fixation. Being a major constituent of the glyoxalase system and ascorbate-glutathione cycle, GSH helps to control multiple abiotic and biotic stress signaling pathways through the regulation of ROS and methylglyoxal (MG) levels. In addition, glutathione metabolism has the potential to be genetically or biochemically manipulated to develop stress-tolerant and nutritionally improved crop plants. Although significant progress has been made in investigating the multiple roles of glutathione in abiotic and biotic stress tolerance, many aspects of glutathione-mediated stress responses require additional research. The main objective of this volume is to explore the diverse roles of glutathione in plants by providing basic, comprehensive, and in-depth molecular information for advanced students, scholars, teachers, and scientists interested in or already engaged in research that involves glutathione. Finally, this book will be a valuable resource for future glutathione-related research and can be considered as a textbook for graduate students and as a reference book for frontline researchers working on glutathione metabolism in relation to plant growth, development, stress responses, and stress tolerance.

Aortic Valve Handbook (Hardcover): Samuel Ostroff Aortic Valve Handbook (Hardcover)
Samuel Ostroff
R3,133 Discovery Miles 31 330 Ships in 12 - 19 working days
Contemporary Aspects of Endocrinology (Hardcover): Evanthia Diamanti-Kandarakis Contemporary Aspects of Endocrinology (Hardcover)
Evanthia Diamanti-Kandarakis
R3,936 Discovery Miles 39 360 Ships in 10 - 15 working days
The Palgrave Handbook of Biology and Society (Hardcover, 1st ed. 2018): Maurizio Meloni, John Cromby, Des Fitzgerald, Stephanie... The Palgrave Handbook of Biology and Society (Hardcover, 1st ed. 2018)
Maurizio Meloni, John Cromby, Des Fitzgerald, Stephanie Lloyd
R6,228 Discovery Miles 62 280 Ships in 12 - 19 working days

This comprehensive handbook synthesizes the often-fractured relationship between the study of biology and the study of society. Bringing together a compelling array of interdisciplinary contributions, the authors demonstrate how nuanced attention to both the biological and social sciences opens up novel perspectives upon some of the most significant sociological, anthropological, philosophical and biological questions of our era. The six sections cover topics ranging from genomics and epigenetics, to neuroscience and psychology to social epidemiology and medicine. The authors collaboratively present state-of-the-art research and perspectives in some of the most intriguing areas of what can be called biosocial and biocultural approaches, demonstrating how quickly we are moving beyond the acrimonious debates that characterized the border between biology and society for most of the twentieth century. This landmark volume will be an extremely valuable resource for scholars and practitioners in all areas of the social and biological sciences. The chapter 'Ten Theses on the Subject of Biology and Politics: Conceptual, Methodological, and Biopolitical Considerations' is open access under a CC BY 4.0 license via link.springer.com. Versions of the chapters 'The Transcendence of the Social', 'Scrutinizing the Epigenetics Revolution', 'Species of Biocapital, 2008, and Speciating Biocapital, 2017' and 'Experimental Entanglements: Social Science and Neuroscience Beyond Interdisciplinarity' are available open access via third parties. For further information please see license information in the chapters or on link.springer.com.

Insulin Resistance (Hardcover): Carlos Rickman Insulin Resistance (Hardcover)
Carlos Rickman
R2,524 Discovery Miles 25 240 Ships in 12 - 19 working days
An IVF Journey Sailing By Love (Hardcover): Si Yao Shining Li An IVF Journey Sailing By Love (Hardcover)
Si Yao Shining Li
R692 Discovery Miles 6 920 Ships in 10 - 15 working days
Quasispecies: From Theory to Experimental Systems (Hardcover, 1st ed. 2016): Esteban Domingo, Peter Schuster Quasispecies: From Theory to Experimental Systems (Hardcover, 1st ed. 2016)
Esteban Domingo, Peter Schuster
R5,069 Discovery Miles 50 690 Ships in 12 - 19 working days

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Cytoskeleton in Specialized Tissues and in Pathological States, Volume 3 (Hardcover): J.E. Hesketh, I. F. Pryme Cytoskeleton in Specialized Tissues and in Pathological States, Volume 3 (Hardcover)
J.E. Hesketh, I. F. Pryme
R2,949 Discovery Miles 29 490 Ships in 12 - 19 working days

This volume deals with aspects of the cytoskeleton in different cell types and also describe examples of changes in the cytoskeleton which occur during various pathological states. These studies bring the exciting area of cytoskeleton research into the domain of medical science.

Digital PCR - Methods and Protocols (Hardcover, 1st ed. 2018): George Karlin-Neumann, Francisco Bizouarn Digital PCR - Methods and Protocols (Hardcover, 1st ed. 2018)
George Karlin-Neumann, Francisco Bizouarn
R8,444 Discovery Miles 84 440 Ships in 10 - 15 working days

This volume explores and explains how digital PCRs (dPCRs) help in the study of numerous topics, such as infectious diseases, evolution of cancer and treatment responses, somatic mosaicism, genome editing and cell therapy, and food testing for GMOs and pathogens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Digital PCR: Methods and Protocols is a valuable resource for specialists in various fields, including geneticists, neurologists, immunologists, oncologists, and researchers who are interested in environmental sciences."

Nutrients and Nutraceuticals for Active & Healthy Ageing (Hardcover, 1st ed. 2020): Seyed Mohammad Nabavi, Grazia... Nutrients and Nutraceuticals for Active & Healthy Ageing (Hardcover, 1st ed. 2020)
Seyed Mohammad Nabavi, Grazia D'Onofrio, Seyed Fazel Nabavi
R5,607 Discovery Miles 56 070 Ships in 10 - 15 working days

This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing - recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.

Membrane Protein Transport, Volume 3 (Hardcover): S. S Rothman Membrane Protein Transport, Volume 3 (Hardcover)
S. S Rothman
R2,904 Discovery Miles 29 040 Ships in 12 - 19 working days

This is the third volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.

Rare Hereditary Cancers - Diagnosis and Management (Hardcover, 1st ed. 2016): Gabriella Pichert, Chris Jacobs Rare Hereditary Cancers - Diagnosis and Management (Hardcover, 1st ed. 2016)
Gabriella Pichert, Chris Jacobs
R3,841 R3,559 Discovery Miles 35 590 Save R282 (7%) Ships in 12 - 19 working days

This book approaches the differential diagnosis and management of rare, hereditary cancer syndromes from a practical angle, addressing the issues pertinent to each tumour type as encountered by health professionals in their day-to-day practice. This book enables readers to correctly identify patients with rare cancer syndromes who would benefit from genetic counselling and testing, and provides the necessary knowledge for appropriate patient management and advising at-risk family members. It begins by describing recent advances in genetic testing for cancer-predisposing genes. Leading experts from Europe and Australia then offer detailed, up-to-date guidance on the diagnosis and management of a wide range of hereditary cancers. The concluding chapter examines the wider issues that are raised by genetic testing for rare cancer syndromes for patients, families and health professionals. This book is an invaluable source of information for all specialists involved in the care of such patients and their families.

Zygotic Genome Activation - Methods and Protocols (Hardcover, 1st ed. 2017): Kiho Lee Zygotic Genome Activation - Methods and Protocols (Hardcover, 1st ed. 2017)
Kiho Lee
R4,726 Discovery Miles 47 260 Ships in 12 - 19 working days

This volume provides an overview of zygotic genome activation (ZGA) and the use of recent tools to elucidate the events that occur during ZGA. The chapters in this book cover topics such as: clearance of maternal RNAs, detection of miRNA in mammalian oocytes and embryos, RNA FISH to study ZGA in early mouse embryos, and CRISPR/Cas9-mediated gene targeting during embryogenesis in the mouse and pig. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Zygotic Genome Activation: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about practical approaches to monitor the changes seen during ZGA.

Lung Inflammation in Health and Disease, Volume I (Hardcover, 1st ed. 2021): Yong-Xiao Wang Lung Inflammation in Health and Disease, Volume I (Hardcover, 1st ed. 2021)
Yong-Xiao Wang
R7,651 Discovery Miles 76 510 Ships in 10 - 15 working days

Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Lipid Metabolism (Hardcover): Donna Thompson Lipid Metabolism (Hardcover)
Donna Thompson
R2,052 R1,886 Discovery Miles 18 860 Save R166 (8%) Ships in 10 - 15 working days
Polyglutamine Disorders (Hardcover, 1st ed. 2018): Clevio Nobrega, Luis Pereira De Almeida Polyglutamine Disorders (Hardcover, 1st ed. 2018)
Clevio Nobrega, Luis Pereira De Almeida
R6,222 Discovery Miles 62 220 Ships in 12 - 19 working days

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

Nitrite and Nitrate in Human Health and Disease (Hardcover, 2nd ed. 2017): Nathan S. Bryan, Joseph Loscalzo Nitrite and Nitrate in Human Health and Disease (Hardcover, 2nd ed. 2017)
Nathan S. Bryan, Joseph Loscalzo
R4,525 Discovery Miles 45 250 Ships in 12 - 19 working days

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Advances in Infancy Research - Volume 11 (Hardcover): Carolyn Rovee-Collier, Lewis P. Lipsitt, Harlene Hayne Advances in Infancy Research - Volume 11 (Hardcover)
Carolyn Rovee-Collier, Lewis P. Lipsitt, Harlene Hayne
R2,786 Discovery Miles 27 860 Ships in 10 - 15 working days

This is part of a series of integrative work by infancy researchers of both humans and animals. The articles seek to serve as references on programmatic series of studies, critical correlations of diverse data that yield to a common theme, and constructive attacks on old issues.

Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases (Hardcover, 1st ed. 2018): Senthilkumar Rajagopal, Murugavel... Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases (Hardcover, 1st ed. 2018)
Senthilkumar Rajagopal, Murugavel Ponnusamy
R2,873 Discovery Miles 28 730 Ships in 10 - 15 working days

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Mathematica for Bioinformatics - A Wolfram Language Approach to Omics (Hardcover, 1st ed. 2018): George Mias Mathematica for Bioinformatics - A Wolfram Language Approach to Omics (Hardcover, 1st ed. 2018)
George Mias
R6,130 Discovery Miles 61 300 Ships in 12 - 19 working days

This book offers a comprehensive introduction to using Mathematica and the Wolfram Language for Bioinformatics. The chapters build gradually from basic concepts and the introduction of the Wolfram Language and coding paradigms in Mathematica, to detailed worked examples derived from typical research applications using Wolfram Language code. The coding examples range from basic sequence analysis, accessing genomic databases, differential gene expression, and machine learning implementations to time series analysis of longitudinal omics experiments, multi-omics integration and building dynamic interactive bioinformatics tools using the Wolfram Language. The topics address the daily bioinformatics needs of a broad audience: experimental users looking to understand and visualize their data, beginner bioinformaticians acquiring coding expertise in providing biological research solutions, and practicing expert bioinformaticians working on omics who wish to expand their toolset to include the Wolfram Language.

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