![]() |
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
|
Your cart is empty |
||
|
Books > Medicine > Pre-clinical medicine: basic sciences
Humans receive the vast majority of sensory perception through the eyes and ears. This non-technical book examines the everyday physics behind hearing and vision to help readers understand more about themselves and their physical environment. It begins wit
"Benign & Pathological Chromosomal Imbalances" systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to
practitioners saves time and money for molecular cytogeneticists
and genetics counselors, helping to distinguish benign from harmful
CG-CNV. It also supports them in deciding which molecular
cytogenetics tools to deploy.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.
This book examines the new knowledge that has been gained from the objective monitoring of habitual physical activity by means of pedometers and accelerometers. It reviews current advances in the technology of activity monitoring and details advantages of objective monitors relative to physical activity questionnaires. It points to continuing gaps in knowledge, and explores the potential for further advances in the design of objective monitoring devices. Epidemiologists have studied relationships between questionnaire assessments of habitual physical activity and various medical conditions for some seventy years. In general, they have observed positive associations between regular exercise and good health, but because of inherent limitations in the reliability and accuracy of physical activity questionnaires, optimal exercise recommendations for the prevention and treatment of disease have remained unclear. Inexpensive pedometers and accelerometers now offer the epidemiologist the potential to collect relatively precisely graded and objective information on the volume, intensity and patterns of effort that people are undertaking, to relate this data to past and future health experience, and to establish dose/response relationships between physical activity and the various components of health. Such information is important both in assessing the causal nature of the observed associations and in establishing evidence-based recommendations concerning the minimal levels of daily physical activity needed to maintain good health.
Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of "Gene Therapy of Cancer" provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum
from gene repair through the use of molecularly modified cells; the
use of viral and non-viral vector based gene delivery to both tumor
and tumor microenvironment; the use of viral and gene based
vaccines; and development of new gene-based therapeutics. The
unique mechanistically chosen vector platforms are at the heart of
this technology because they allow for direct and selective cell
death and transient to sustained delivery of vaccine molecules or
molecules that affect the microenvironment, vasculature, or the
immune response.
"Aging: Oxidative Stress and Dietary Antioxidants" bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are
separated by divergent skills and professional disciplines that
need to be bridged in order to advance preventative as well as
treatment strategies. While gerontologists and geriatricians may
study the underlying processes of aging, they are less likely to be
conversant in the science of nutrition and dietetics. On the other
hand, nutritionists and dietitians are less conversant with the
detailed clinical background and science of gerontology. This book
addresses this gap and brings each of these disciplines to bear on
the processes inherent in the oxidative stress of aging.
Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. "Omega-3 Fatty Acids in Brain and Neurological Health" is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and
the developing brain, aging, dementia, Alzheimer's disease and
multiple sclerosis. This book encompasses some of the most recent
research, including the role of omega-3 fatty acid supplements on
hippocampal neurogenesis, substantia nigra modulation, migraine
headaches, the developing brain in animals, sleep, and
neurodegenerative diseases. This collection helps to push research
forward toward a complete understanding of omega-3 fatty acids'
relationship to brain and neurological health.
"Advances in Cancer Research" provides invaluable information on
the exciting and fast-moving field of cancer research. Here, once
again, outstanding and original reviews are presented on a variety
of topics. This volume covers AEG-1/MTDH/Lyric implicated in
multiple human cancers.
This issue of Nursing Clinics of North America is Guest Edited by? Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University and will focus on genomics. Article topics will include Genetic and Genomic Testing, Integrating Genomics into Research, Genomic Assessments and Interventions in Psychiatric Nursing Practice, Genomics in Critical Care, Cardiomyopathy and Genetics, Genetics and Chronic Diseases, Genomics and Patients with Rare Chronic Diseases, Epigenetics and the implications for disease processes, Impact of Genetics on Oncology Nursing, and Pharmacogenetics.
"The Atlas of Chick Development, Third Edition," a classic work covering all major event of chick development, is extensively updated with new and more detailed photographs, enlargements showing regions of special-interest and complexity, and new illustrations. The revised text and expanded illustrative material describe the intricate changes that take place during development, together with accounts of recent experimental and molecular research that has transformed our understanding of morphogenesis. These wide-ranging updates make this book an essential resource
for developmental biologists, geneticists, molecular biologists,
poultry scientists, biochemists, immunologists, and other life
scientists who use the chick embryo as their research model.
Individuals joining this burgeoning area, ignited by the increased
insight into events surrounding organ and tissue differentiation,
will find this a valuable tool to help grow a basic knowledge of
morphogenesis.
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Biocidal polymers are designed to inhibit or kill microorganisms such as bacteria, fungi and protozoans. This book summarizes recent findings in the synthesis, modification and characterization of various antimicrobial polymers ranging from plastics and elastomers to biomimetic and biodegradable polymers. Modifications with different antimicrobial agents as well as antimicrobial testing methods are described in a comprehensive manner.
PIWI-interacting RNAs (piRNAs) are the third and most-recently discovered group of silencing-inducible small RNAs in animals. PIWI-Interacting RNAs: Methods and Protocols provides the most recent methods and protocols for studying piRNAs in the gonads of a wide range of species, as well as in any other organs where piRNAs may be detected. Comprehensive high-throughput sequencing analysis of piRNAs in embryos, testes and ovaries of D. melanogaster, as well as in mouse and rat testes, has raised the profile of piRNAs and thus further accelerated piRNA studies. In addition to C. elegans, other model species such as Drosophila melanogaster, Arabidopsis thaliana and mice, along with cultured cell lines such as HeLa and Drosophila Schneider 2 (S2), and other such organisms have been used to address the fundamental questions of the biogenesis and functions of RNAi-triggering small non-coding RNAs. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, PIWI-Interacting RNAs: Methods and Protocols seeks to serve both established researchers and newcomers to the field to progress towards the ultimate goal of understanding the mechanisms and actions of piRNAs.
Volume 542 of "Methods in Enzymology" continues the legacy of this
premier serial with quality chapters authored by leaders in the
field. This new volume covers research methods providing a
theoretical overview on metabolic alterations of cancer cells and a
series of protocols that can be employed to study oncometabolism,
in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic
changes when compared to their normal counterparts, owing to both
genetic and epigenetic alterations. Although such a metabolic
rewiring has recently been indicated as "yet another" general
hallmark of cancer, accumulating evidence suggests that the
metabolic alterations of each neoplasm rather represent a molecular
signature that intimately accompanies, and hence cannot be severed
from, all facets of malignant transformation.
The memoir of the first scientist to collect and publish
information on mind altering drugs, longevity, meditation
techniques, and ecological living.
This books aims to provide an up-to-date guide to using recombinases in the laboratory. Chapters guide the reader through construction of transgenic animals, recombinase-mediated cassette exchange (RMCE), spatial control of recombinase expression and in vivo delivery approaches, immunohistochemistry and fluorescence-based phenotyping methods, biochemical methods, and recombinase-based production of minimal DNA vectors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Site-Specific Recombinases: Methods and Protocols aims to serve as a valuable resource for working with recombinases, and inspires further creativity in the field.
This is a comprehensive book addressing steroid disorders from
hormonal, genetic, psychological, and surgical perspectives. It is
meant to educate adult and pediatric endocrinologists, clinical
geneticists, genetic counselors, reproductive endocrinologists,
neonatologists, urologists, and psychoendocrinologists. It will
assist these specialists in the diagnosis and treatment of steroid
disorders. The book is written for postgraduate and faculty-level
physicians. The content consists of steroid disorders, genetic
bases for the disorder and case presentations of each
disorder.
This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.
This new volume of "Methods in Enzymology" continues the legacy of
this premier serial with quality chapters authored by leaders in
the field. This volume covers cytoskeletal structure, including
such topics as rotational movement of formins studied by
fluorescence polarization microscopy, in vitro assembly assays for
bacterial actin filaments, and modulators of microtubule plus end
growth.
"Clinical Anatomy of the Cranial Nerves" combines anatomical
knowledge, pathology, clinical examination, and explanation of
clinical findings, drawing together material typically scattered
throughout anatomical textbooks. All of the pertinent anatomical
topics are conveniently organized to instruct on anatomy, but also
on how to examine the functioning of this anatomy in the patient.
Providing a clear and succinct presentation of the underlying
anatomy, with directly related applications of the anatomy to
clinical examination, the book also provides unique images of
anatomical structures of plastinated cadaveric dissections. These
images are the only ones that exist in this form, and have been
professionally produced in the Laboratory of Human Anatomy,
University of Glasgow under the auspices of the author. These
specimens offer a novel way of visualizing the cranial nerves and
related important anatomical structures.
This volume of the esteemed "Progress in Molecular Biology and Translational Science" series focuses on cutting-edge research related to the genetics of cardiovascular disease. Written by top experts in the field, this volume covers a range of topics, including: Genetic models of atherosclerosis MicroRNAs in cardiovascular disease The role of the transcription factor KLF2 in vascular development and disease Zebrafish as models of cardiovascular disease and hematopoietic development "Progress in Molecular Biology and Translational Science"
provides a forum for discussion of new discoveries, approaches, and
ideas in molecular biology. It contains contributions from leaders
in their fields and abundant references. Key features: The authors are all experts in the fieldThe reviews are in themselves comprehensiveEach topic has the potential to lead to advances in therapy of cardiovascular disease
This volume provides broad coverage of computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those concerned with general techniques and concepts that apply to all organisms to others that are more specialized, covering specific biological systems such as viruses, Drosophila, and Homo sapiens. Written in the highly successful Methods in Molecular Biology series format, by authors who are active researchers in the field, many chapters include step-by-step procedures, which illustrate practical applications of the techniques described. Cutting-edge and thorough, Comparative Genomics: Methods and Protocols should be useful to students and researchers in the continually growing and exciting field of comparative genomics.
|
You may like...
Fertility SOS - A Proven Plan To Counter…
Daminda Senekal-Griessel
Paperback
Risking Life For Death - Lessons For The…
Ryan Blumenthal
Paperback
(1)
Herbal Bioactive-Based Drug Delivery…
Not available
Inderbir Singh Bakshi, Rajni Bala, …
Paperback
R3,967
Discovery Miles 39 670
Human Physiology - From Cells to Systems
Lauralee Sherwood
Hardcover
Fundamentals of Human Embryology…
John Allan, Beverley Kramer
Paperback
|