Gene therapy as a treatment for cancer is at a critical point in
its evolution. Exciting new developments in gene targeting and
vector technology, coupled with results from the first generation
of preclinical and clinical studies have led to the design and
testing of new therapeutic approaches. The Third Edition of "Gene
Therapy of Cancer" provides crucial updates on the basic and
applied sciences of gene therapy. It offers a comprehensive
assessment of the field including the areas of suicide gene
therapy, oncogene and suppressor gene targeting, immunotherapy,
drug resistance gene therapy, and the genetic modification of stem
cells. Researchers at all levels of development, from basic
laboratory investigators to clinical practitioners, will find this
book to be instructive.
Cancer gene therapy, like cancer therapy in general, is evolving
rapidly, testing new concepts, targets and pathways, evoking new
technologies, and passing new regulatory hurdles. Its essence,
however, has not changed: the hope and challenges of returning
altered genes to normal, using targeted gene expression to alter
the function of both tumor and microenvironment, and in some cases
normal cells, and delivering functionally important genes to
specific cell types to increase sensitivity to killing or to
protect normal cells from cancer therapies.
In some instances, gene therapy for cancer forms a continuum
from gene repair through the use of molecularly modified cells; the
use of viral and non-viral vector based gene delivery to both tumor
and tumor microenvironment; the use of viral and gene based
vaccines; and development of new gene-based therapeutics. The
unique mechanistically chosen vector platforms are at the heart of
this technology because they allow for direct and selective cell
death and transient to sustained delivery of vaccine molecules or
molecules that affect the microenvironment, vasculature, or the
immune response.
Explains the underlying cancer biology necessary for understanding
proposed therapeutic approaches Presents in-depth description of
targeting systems and treatment strategiesCovers the breadth of
gene therapy approaches including immunotherapeutic, drug
resistance, oncolytic viruses, as well as regulatory perspectives
from both the NCI and FDA
General
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