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Books > Medicine > Pre-clinical medicine: basic sciences

Sphingolipids: Basic Science and Drug Development (Hardcover, 2013 ed.): Erich Gulbins, Irina Petrache Sphingolipids: Basic Science and Drug Development (Hardcover, 2013 ed.)
Erich Gulbins, Irina Petrache
R8,290 R6,224 Discovery Miles 62 240 Save R2,066 (25%) Ships in 12 - 17 working days

Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context."

Relative Strangers: Family Life, Genes and Donor Conception (Hardcover): Petra Nordqvist, C. Smart Relative Strangers: Family Life, Genes and Donor Conception (Hardcover)
Petra Nordqvist, C. Smart
R2,532 R1,778 Discovery Miles 17 780 Save R754 (30%) Ships in 12 - 17 working days

What does it mean to have a child born through donor conception? Does it mean different things for heterosexual parents and lesbian parents? What is it like for the 'non-genetic' parent? How do grandparents feel about having a grandchild who is conceived with the help of an egg, sperm or embryo donor? Since 1991 more than 35,000 children have been born in the UK as a result of donor conception. This means that more and more families are facing the issue of incorporating 'relative strangers' into their families.
In this path breaking book, the authors explore the lived reality of donor conception in families by using in-depth interviews with parents and grandparents of donor conceived children. With reproductive medical technologies becoming more accessible, assisted donor conception is raising new and important questions about family life. This book will provide compelling reading for all those interested in the family, kinship, gender and sexuality, new reproductive technologies, and genetics.

New Challenges for Cancer Systems Biomedicine (Hardcover, 2012 ed.): Alberto d'Onofrio, Paola Cerrai, Alberto Gandolfi New Challenges for Cancer Systems Biomedicine (Hardcover, 2012 ed.)
Alberto d'Onofrio, Paola Cerrai, Alberto Gandolfi
R2,853 Discovery Miles 28 530 Ships in 10 - 15 working days

The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.

Atlas of X-Linked Intellectual Disability Syndromes (Hardcover, 2nd Revised edition): Roger E. Stevenson, Charles E. Schwartz,... Atlas of X-Linked Intellectual Disability Syndromes (Hardcover, 2nd Revised edition)
Roger E. Stevenson, Charles E. Schwartz, R Curtis Rogers
R5,839 Discovery Miles 58 390 Ships in 12 - 17 working days

The Atlas of X-Linked Intellectual Disability Syndromes is a comprehensive and up-to-date summary of the clinically distinctive disorders caused by genes on the X chromosome. Clinical and laboratory data on 150 syndromes are presented in a concise and consistent manner. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. Individual syndrome entries are supplemented with nineteen appendices that identify syndromes with common features and provide the location or mapping limits and function of the responsible genes. The authors have extensive experience in the clinical and laboratory delineation of X-linked intellectual disability. They have described new syndromes, regionally mapped disease loci on the X chromosome, and identified the genes responsible for X-linked syndromes.

Next Generation Sequencing - Current Technologies and Applications (Hardcover, New): Jianping Xu Next Generation Sequencing - Current Technologies and Applications (Hardcover, New)
Jianping Xu
R5,513 Discovery Miles 55 130 Ships in 10 - 15 working days

This text explores the most recent advances in NGS instrumentation and data anlysis. It begins with a comprehensive description of current NSG platforms, their sequencing chemistries, instrument specifications, and general workflows and procedures. A separate chapter is dedicated to low-quanitity, single molecule sequencing technology. Further chapters explore the application of NSG technologies in various fields.

Stem Cells: Current Challenges and New Directions (Hardcover, 2013 ed.): Kursad Turksen Stem Cells: Current Challenges and New Directions (Hardcover, 2013 ed.)
Kursad Turksen
R5,374 R4,806 Discovery Miles 48 060 Save R568 (11%) Ships in 12 - 17 working days

This volume looks at the state-of-the-science in stem cells, discusses the current challenges, and examines the new directions the field is taking. Dr. Turksen, editor-in-chief of the journal "Stem Cell Reviews and Reports," has assembled a volume of internationally-known scientists who cover topics that are both clinically and research-oriented. The contents range from sources of stem cells through their physiological role in health and disease, therapeutic applications in regenerative medicine, and ethics and society. An initial overview and a final summary bookend the contents into a cohesive and invaluable volume.

What Makes a Person? - Secrets of our first 1,000 days (Paperback): Mark Hanson, Lucy Green What Makes a Person? - Secrets of our first 1,000 days (Paperback)
Mark Hanson, Lucy Green
R239 Discovery Miles 2 390 Ships in 12 - 17 working days

Ever wondered why your life and health can sometimes be so hard to control? Or why it seems so easy for other people? Mark Hanson and Lucy Green draw on their years of experience as scientists and educators to cut through the usual information on genetics and lifestyle to reveal the secrets of early development which start to make each of us unique, during our first 1,000 days from the moment of conception. Some surprising discoveries, based on little-known new research, show how events during our first 1,000 days make each of us who we are and explain how we control our bodies, processes that go way beyond just the genes which we inherited. Provoking new ways of thinking about being parents, this book empowers individuals and society to give the next generation the gift of a good start to life and future health.

Lippincott Illustrated Reviews: Biochemistry (Paperback, Eighth, International Edition): Emine E. Abali, Susan D. Cline, David... Lippincott Illustrated Reviews: Biochemistry (Paperback, Eighth, International Edition)
Emine E. Abali, Susan D. Cline, David S. Franklin, Susan M. Viselli
R1,230 Discovery Miles 12 300 Ships in 12 - 17 working days

Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. Praised by faculty and students for more than two decades, Lippincott (R) Illustrated Reviews: Biochemistry is the long-established go-to resource for mastering the essentials of biochemistry. This best-selling text helps students quickly review, assimilate, and integrate large amounts of critical and complex information, with unparalleled illustrations that bring concepts to life. Like other titles in the popular Lippincott (R) Illustrated Review Series, this text follows an intuitive outline organization and boasts a wealth of study aids that clarify challenging information and strengthen retention and understanding. This updated and revised edition emphasizes clinical application and features new exercises, questions, and accompanying digital resources to ready students for success on exams and beyond. NEW! Clinical Application boxes train students to confidently apply biochemistry in clinical scenarios. NEW! Cross-references to other Lippincott (R) Illustrated Reviews titles help students grasp how biochemical concepts relate to other basic sciences. UPDATED! Vibrant illustrations and detailed tables clarify complex biochemical concepts. NEW and UPDATED! Study Questions and Answers for each chapter test students' retention and strengthen their test-taking confidence. UPDATED! Integrative Case Studies with Review Questions familiarize students with commonly encountered clinical scenarios and alert them to potential widespread implications of presenting issues. NEW! Animations enhance students' understanding of biochemical concepts and processes with vivid detail and accuracy. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

The Professional Responsibility Model of Perinatal Ethics (Hardcover, Digital original): Frank A. Chervenak, Laurence B.... The Professional Responsibility Model of Perinatal Ethics (Hardcover, Digital original)
Frank A. Chervenak, Laurence B. McCullough
R3,915 Discovery Miles 39 150 Ships in 12 - 17 working days

This book provides the first clinically comprehensive and practical approach to ethical challenges in perinatal medicine.The first chapter introduces and explains the professional responsibility model of perinatal ethics.The professional responsibility model is based on the medical ethics of two major physician-ethics in the history of Western medical ethics, Dr. John Gregory (1724-1773) of Scotland and Dr. Thomas Percival (1740-1804) of England.The professional responsibility model is used to articulate the ethical concept of the fetus as a patient and to operationalize the ethical principles of beneficence and respect for autonomy.The book provides practical guidance for clinical judgment and decision making with patients about the responsible clinical management of the wide range of issues encountered by perinatologists in clinical practice and research.Topics included: periviability; feticide; intrapartum management; maternal-fetal conflict; innovation for fetal benefit; research for fetal benefit; non-aggressive obstetric management; managing the transition from pregnancy to birth; destructive procedures such as cephalocentesis; critical care for the pregnant patient; home birth; patient-choice cesarean delivery; neonatal care as a trial of management; and setting limits on neonatal care on the basis of clinical judgments of futility.

RNA Mapping - Methods and Protocols (Hardcover, 2014): M. Lucrecia Alvarez, Mahtab Nourbakhsh RNA Mapping - Methods and Protocols (Hardcover, 2014)
M. Lucrecia Alvarez, Mahtab Nourbakhsh
R4,951 Discovery Miles 49 510 Ships in 12 - 17 working days

In "RNA Mapping- Methods and Protocols" expert researchers in the field detail many of the methods which are now commonly used to study RNA. These include protocols for the consequence of the emerging interest in the characterization of cellular RNAs urged by their potential use as diagnostic biomarkers or therapeutic targets. In particular, the biological relevance of microRNAs in human physiology and disease development is highlighted in the 16 chapters focused on methods for their physical and functional mapping. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, "RNA Mapping- Methods and Protocols" provides instruction and inspiration for scientists who are facing the challenges of the discovery and/or functional characterization of RNA molecules for a wide variety of applications ranging from novel biomedical diagnostics to therapeutics and biomaterials.

Fertility, Conjuncture, Difference - Anthropological Approaches to the Heterogeneity of Modern Fertility Declines (Hardcover):... Fertility, Conjuncture, Difference - Anthropological Approaches to the Heterogeneity of Modern Fertility Declines (Hardcover)
Philip Kreager, Astrid Bochow
R2,884 Discovery Miles 28 840 Ships in 12 - 17 working days

In the last forty years anthropologists have made major contributions to understanding the heterogeneity of reproductive trends and processes underlying them. Fertility transition, rather than the story of the triumphant spread of Western birth control rationality, reveals a diversity of reproductive means and ends continuing before, during, and after transition. This collection brings together anthropological case studies, placing them in a comparative framework of compositional demography and conjunctural action. The volume addresses major issues of inequality and distribution which shape population and social structures, and in which fertility trends and the formation and size of families are not decided solely or primarily by reproduction.

Muscarinic Receptors (Hardcover, 2012): Allison D. Fryer, Arthur Christopoulos, Neil M. Nathanson Muscarinic Receptors (Hardcover, 2012)
Allison D. Fryer, Arthur Christopoulos, Neil M. Nathanson
R11,341 R8,135 Discovery Miles 81 350 Save R3,206 (28%) Ships in 12 - 17 working days

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.

Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools (Hardcover, 1st ed. 2016): Maurizio Federico Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools (Hardcover, 1st ed. 2016)
Maurizio Federico
R3,465 Discovery Miles 34 650 Ships in 12 - 17 working days

This volume provides current methods and protocols for gene and protein delivery based on both lentivirus-generated and spontaneously released nanovesicles. Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools guides readers through methods on macromolecule delivery and chapters describe the LV-based protocols of gene engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools aims to ensure successful results in the further study of this vital field.

Prevention and Management of Dyslipidemia (Hardcover): Donna Thompson Prevention and Management of Dyslipidemia (Hardcover)
Donna Thompson
R2,196 Discovery Miles 21 960 Ships in 12 - 17 working days
Breath Taking - The Power, Fragility, and Future of Our Extraordinary Lungs (Paperback): Michael J. Stephen Breath Taking - The Power, Fragility, and Future of Our Extraordinary Lungs (Paperback)
Michael J. Stephen
R470 R408 Discovery Miles 4 080 Save R62 (13%) Ships in 10 - 15 working days

From an expert in pulmonary medicine, the story of our extraordinary lungs, the organ that both explains our origins and holds the keys to our future as a species We take an average of 7.5 million breaths a year and some 600 million in our lifetime, and what goes on in our body each time oxygen is taken in and carbon dioxide expelled is nothing short of miraculous. "Our lungs are the lynchpin between our bodies and the outside world," writes Dr. Michael Stephen. And yet, we take our lungs for granted until we're incapacitated and suddenly confronted with their vital importance. In Breath Taking, pulmonologist Michael Stephen takes us on a journey to shed original and much-needed light on our neglected and extraordinary lungs, at a most critical societal moment. He relates the history of oxygen on Earth and the evolutionary origins of breathing, and explores the healing power of breath and its spiritual potential. He explains in lay terms the links our lungs have with our immune system and with society at large. And he offers illuminating chronicles of pulmonary research and discovery--from Galen in the ancient world to pioneers of lung transplant--and poignant human stories of resilience and recovery--from the frantic attempts to engage his own son's lungs at birth to patients he treats for cystic fibrosis today. Despite great advances in science, our lungs are ever more threatened. Asthma is more prevalent than ever; rising stress levels make our lungs vulnerable to disease; and COVID-19 has revealed that vulnerability in historic ways. In this time, Breath Taking offers inspiration and hope to millions whose lungs are affected and vital perspective to us all.

In Silico Tools for Gene Discovery (Hardcover, 2011 ed.): Bing Yu, Marcus Hinchcliffe In Silico Tools for Gene Discovery (Hardcover, 2011 ed.)
Bing Yu, Marcus Hinchcliffe
R4,318 Discovery Miles 43 180 Ships in 10 - 15 working days

As functional genomics has become one of the major focuses in molecular biology, the need for more sophisticated tools to assist in the identification of the functionality of undefined genes and the correlation of DNA variants with a particular phenotype has increased greatly. In Silico Tools for Gene Discovery collects many common and useful in silico tools available today. The volume begins by investigating locus mapping information on linkage analysis, association mapping, integrative analysis, and exome analysis as well as tools for DNA marker selection, in silico PCR, and statistical analysis. It continues with a section on gene discovery from a defined locus, including gene prioritization, knowledge tracking, and data mining, and concludes with several useful in silico tools presented for the functional characterization of genes, which include DNA sequencing analysis, variant characterization, as well as RNA and protein analysis. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, step-by-step, readily reproducible protocols, and vital notes on troubleshooting and avoiding known pitfalls. Resourceful and easy to follow, In Silico Tools for Gene Discovery seeks to facilitate scientists with further key research on locus mapping, to accelerate gene identification, and to help ascertain the functionality of DNA variation.

Prostate Biopsy - Indications, Techniques, and Complications (Hardcover, 2008 ed.): J. Stephen Jones Prostate Biopsy - Indications, Techniques, and Complications (Hardcover, 2008 ed.)
J. Stephen Jones
R4,240 Discovery Miles 42 400 Ships in 10 - 15 working days

Prostate biopsy is now one of the most common procedures performed by urologists. This book presents all topics related to the diagnosis of prostate cancer, including risk factor assessment, indications for biopsy, techniques, complications, and emerging technologies in the science. It also covers such important topics in prostate biopsy as PSA, pain prevention, prediction models, and biopsy techniques. The book's contributors include those who have defined the science of prostate cancer diagnosis and continue to improve upon it. These internationally acclaimed specialists provide their expert opinions on all topics related to prostate cancer diagnosis.

Lymphoma - Methods and Protocols (Hardcover, 2013 ed.): Ralf Kuppers Lymphoma - Methods and Protocols (Hardcover, 2013 ed.)
Ralf Kuppers
R4,805 R3,521 Discovery Miles 35 210 Save R1,284 (27%) Ships in 12 - 17 working days

Lymphomas are lymphoid malignancies derived from B or T lymphocytes, and their study has been and still is paradigmatic for many aspects of cancer research. Lymphoma: Methods and Protocols presents and discusses key methods that are used in lymphoma research, partly specific for lymphoma research but often adaptable to the study of other cancers. By covering a broad variety of methods used in lymphoma research, this book will be of interest not only for hematologists, hematopathologists, and immunologists but also for scientists interested in other fields of cancer research as well as human genetics. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Lymphoma: Methods and Protocols serves researchers studying human physiology with the ultimate goal of understanding and controlling these often terrible diseases.

Genetic Disorders Among Arab Populations (Hardcover, 2nd ed. 2010): Ahmad S. Teebi Genetic Disorders Among Arab Populations (Hardcover, 2nd ed. 2010)
Ahmad S. Teebi
R5,891 Discovery Miles 58 910 Ships in 10 - 15 working days

Arab populations have their "own" genetic disorders, both universal and particular. Genetic diversity within these source populations, along with the fact that the rates of inbreeding are often high and family sizes are often large, constitute conditions that facilitate the emergence and detection of phenotypes explained notably by autosomal recessive inheritance; in which case, the use of homozygosity gene mapping can facilitate the discovery of the corresponding genes. The present book includes 5 parts dealing with various aspects that relate to the genetic structure of Arabs and minorities within the Arab world as well as genetic disorders prevalent in this part of the world. It includes updated reviews of the genetic disorders in various Arab countries and geographic regions. The focus is primarily, but not exclusively, on the group of single-gene disorders with particular emphasis on autosomal recessive conditions. It further includes epidemiological and clinical data as well as inheritance patterns, mutation and polymorphism data, and available haplotype analysis data. The ethnic and genetic diversity of the Arab populations is discussed as well as aspects of genetic counseling practice in this region together with a proposal for an ethical framework for genetic research and prevention of genetic disorders. The target audience of this book includes human and medical geneticists, genetic counselors, researchers, medical specialists dealing with Arab patients or practicing in Arab countries, medical and genetic counseling students, and nurses.

Histone Deacetylases - Transcriptional Regulation and Other Cellular Functions (Hardcover, 2006 ed.): Eric Verdin Histone Deacetylases - Transcriptional Regulation and Other Cellular Functions (Hardcover, 2006 ed.)
Eric Verdin
R5,490 Discovery Miles 54 900 Ships in 10 - 15 working days

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

DNA Cloning and Assembly Methods (Hardcover, 2014 ed.): Svein Valla, Rahmi Lale DNA Cloning and Assembly Methods (Hardcover, 2014 ed.)
Svein Valla, Rahmi Lale
R4,785 Discovery Miles 47 850 Ships in 12 - 17 working days

In DNA Cloning and Assembly Methods, expert researchers in the field detail many of the methods which are now commonly used for DNA cloning and make cloning procedures faster, more reliable and also suitable for high-throughput handling. These include methods and protocols that are based on several mechanisms including type II and IIS restriction enzymes, single stranded annealing, sequence overlap, and recombination. With additional chapters on software programs that are suitable for primer design, a feature crucial for the functionality of the described methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, DNA Cloning and Assembly Methods seeks to provide scientist with a valuable and useful resource for wet lab researchers within life sciences.

Cell Therapy - cGMP Facilities and Manufacturing (Hardcover, 2009 ed.): Adrian Gee Cell Therapy - cGMP Facilities and Manufacturing (Hardcover, 2009 ed.)
Adrian Gee
R5,231 Discovery Miles 52 310 Ships in 12 - 17 working days

Cell Therapy: cGMP Facilities and Manufacturing is the source for a complete discussion of facility design and operation with practical approaches to a variety of day-to-day activities, such as staff training and competency, cleaning procedures, and environmental monitoring. This in-depth book also includes detailed reviews of quality, the framework of regulations, and professional standards. It meets a previously unmet need for a thorough facility-focused resource, Cell Therapy: cGMP Facilities and Manufacturing will be an important addition to the cell therapy professionala (TM)s library.

Additional topics in Cell Therapy: cGMP Facilities and Manufacturinga ]

  • Standard operating procedures
  • Supply management
  • Facility equipment
  • Product manufacturing, review, release and administration
  • Facility master file
Biomedical Imaging and Computational Modeling in Biomechanics (Hardcover, 2013 ed.): Ugo Andreaus, Daniela Iacoviello Biomedical Imaging and Computational Modeling in Biomechanics (Hardcover, 2013 ed.)
Ugo Andreaus, Daniela Iacoviello
R4,312 R3,308 Discovery Miles 33 080 Save R1,004 (23%) Ships in 12 - 17 working days

This book collects the state-of-art and new trends in image analysis and biomechanics. It covers a wide field of scientific and cultural topics, ranging from remodeling of bone tissue under the mechanical stimulus up to optimizing the performance of sports equipment, through the patient-specific modeling in orthopedics, microtomography and its application in oral and implant research, computational modeling in the field of hip prostheses, image based model development and analysis of the human knee joint, kinematics of the hip joint, micro-scale analysis of compositional and mechanical properties of dentin, automated techniques for cervical cell image analysis, and biomedical imaging and computational modeling in cardiovascular disease.

The book will be of interest to researchers, Ph.D students, and graduate students with multidisciplinary interests related to image analysis and understanding, medical imaging, biomechanics, simulation and modeling, experimental analysis

Embryo Culture - Methods and Protocols (Hardcover, 2012 ed.): Gary D Smith, Jason E. Swain, Thomas B. Pool Embryo Culture - Methods and Protocols (Hardcover, 2012 ed.)
Gary D Smith, Jason E. Swain, Thomas B. Pool
R2,901 Discovery Miles 29 010 Ships in 10 - 15 working days

Assisted reproductive technologies have had a profound impact on biomedical research through transgenic animals, food supply and production, as wells as genetic gain of domestic species, and treatment of human infertility. While significant advances in embryo culture have occurred over the last few decades. In Embryo Culture: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study human embryo culture. These include emerging methods and the impact of embryo culture on epigenetics and offspring health is presented to set the stage for future research and laboratory application involving embryo culture. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Embryo Culture: Methods and Protocols seeks to aid scientists in the further study of this crucially important field of embryology and assisted reproductive technologies.

Reproductive Sciences in Animal Conservation (Hardcover, 2nd ed. 2019): Pierre Comizzoli, Janine L. Brown, William V. Holt Reproductive Sciences in Animal Conservation (Hardcover, 2nd ed. 2019)
Pierre Comizzoli, Janine L. Brown, William V. Holt
R6,257 Discovery Miles 62 570 Ships in 10 - 15 working days

This second edition emphasizes the environmental impact on reproduction, with updated chapters throughout as well as complete new chapters on species such as sharks and rays. This is a wide-ranging book that will be of relevance to anyone involved in species conservation, and provides critical perspectives on the real utility of current and emerging reproductive sciences.Understanding reproductive biology is centrally important to the way many of the world's conservation problems should be tackled. Currently the extinction problem is huge, with up to 30% of the world's fauna being expected to disappear in the next 50 years. Nevertheless, it has been estimated that the global population of animals in zoos encompasses 12,000 - 15,000 species, and we anticipate that every effort will be made to preserve these species for as long as possible, minimizing inbreeding effects and providing the best welfare standards available. Even if the reproductive biology community cannot solve the global biodiversity crisis for all wild species, we should do our best to maintain important captive populations. Reproductive biology in this context is much more than the development of techniques for helping with too little or too much breeding. While some of the relevant techniques are useful for individual species that society might target for a variety of reasons, whether nationalistic, cultural or practical, technical developments have to be backed up by thorough biological understanding of the background behind the problems.

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