Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Buhring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank Entschladen Dissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong Chen Does the Adult Stroma Contain Stem Cells?, by Richard Schafer

First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This book presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system-the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory-at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.
The book also includes an enlightening DVD describing the basic surface anatomy of the cerebral hemispheres, coronal and horizontal sections, and blunt dissection of the forebrain with special attention to clinical-anatomical correlations of interest to psychiatrists.
* A re-evaluation of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century
* A compellingly expanded conceptualization of Broca's famous limbic lobe
* Clinical and basic science boxes highlighting specific concepts, structures, or neuronal circuits from a clinical perspective
* DVD illustrating dissection of the human brain by one of the world's masters

Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity.

International Review of Cytology presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Mechanisms of Gradient Detection: A Comparison of Axon Pathfinding with Eukaryotic Cell Migration; Leptin and the Regulation of Hypothalamic-Pituitary-Adrenal Axis; Focal Adhesion and p53 Signaling in Cancer Cells; Cell and Molecular Biology of the Spindle Matrix; Mitochondrial Biology and Disease in Dictyostelium; Oxytocin and the Human Prostate in Health and Disease.

In this fascinating book, Jacques Balthazart presents a simple description of the biological mechanisms that are involved in the determination of sexual orientation in animals and also presumably in humans. Using scientific studies published over the last few decades, he argues that sexual orientation, both homosexual and heterosexual, is under the control of embryonic endocrine and genetic phenomena in which there is little room for individual choice. The author begins with animal studies of the hormonal and neural mechanisms that control the so-called instinctive behaviors and analyzes how this animal work may potentially apply to humans. The book does not focus exclusively on homosexuality, however. Instead, the book acts as a broader guide to the biological basis of sexual orientation, and also discusses important gender differences that may influence sexual orientation. While firmly grounded in the scientific literature, this text is developed for a broader audience and will be of interest to psychologists, researchers, students, and anyone interested in the biological factors that determine our sexuality.

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

This book explores implicit choices made by researchers, policy makers, and funders regarding who benefits from society's investment in health research. The authors focus specifically on genetic research and examine whether such research tends to reduce or exacerbate existing health disparities. Using case examples to illustrate the issues, the authors trace the path of genetics research from discovery, through development and delivery, to health outcomes. Topics include breast cancer screening and treatment, autism research, pharmacogenetics, prenatal testing, newborn screening, and youth suicide prevention. Each chapter emphasizes the societal context of genetic research and illustrates how science might change if attention were paid to the needs of marginalized populations. Written by experts in genetics, health, and philosophy, this book argues that the scientific enterprise has a responsibility to respond to community needs to assure that research innovations achieve much needed health impacts.

This book is a concise guide to the diagnosis and management of reproductive health issues in adolescents that may lead to future fertility problems. Beginning with an overview of female adolescence and reproductive development, the following chapters cover different disorders including PCOS (polycystic ovary syndrome), endometriosis, anaemia, menstrual abnormalities, teenage pregnancy and abortion, STIs and more. Each section provides step by step guidance from history taking, signs and symptoms, and clinical examination, to diagnosis and therapy. A complete chapter covers the 2012 POCSO (Protection of Children from Sexual Offences) Act. Key points Concise guide to reproductive health issues in adolescents, subsequently leading to fertility problems Discusses investigation, diagnosis and management of numerous disorders Covers POCSO Act 2012 Includes clinical images and figures to assist learning

Cytology refers to a branch of pathology that deals with making diagnoses of diseases and conditions through the examination of tissue samples from the body (MedicineNet.com). Immunocytochemistry is a laboratory method that uses antibodies to check for certain antigens (markers) in a sample of cells. The antibodies are usually linked to an enzyme or a fluorescent dye. After the antibodies bind to the antigen in the cell sample, the enzyme or dye is activated, and the antigen can then be seen under a microscope. Immunocytochemistry is used to help diagnose diseases, such as cancer. It may also be used to help tell the difference between different types of cancer (National Cancer Institute). This book is a comprehensive guide to the techniques and application of immunocytochemistry in cytology. Divided into two parts, the first section discusses basic principles and preparation, techniques and quality control, and automated immune staining. Section Two covers diagnostic applications of immunocytochemistry for many different types of tumour. The text is highly illustrated with microphotographs, tables and boxes to assist learning and interpretation of findings for accurate diagnosis. Key points Comprehensive guide to techniques and application of immunocytochemistry in cytology Provides thorough understanding of basic principles and methods Covers diagnostic applications for many different types of tumour Highly illustrated with microphotographs, tables and boxes

The integrated and advanced science research topic Man-Machine-Environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: You have created a very important modern science and technology in China
MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, man refers to people in the workplace (e.g. operators, decision-makers); machine is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and environment describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of Man-Machine-Environment systems are to ensure safety, efficiency and economy.
"Proceedings of the 13th International Conference on Man-Machine-Environment System Engineering" are an academic showcase of the best papers selected from more than 400 submissions, introducing readers to the top research topics and the latest developmental trends in the theory and application of MMESE.
These proceedings are interdisciplinary studies on the concepts and methods of physiology, psychology, system engineering, computer science, environment science, management, education, and other related disciplines. Researchers and professionals working in these interdisciplinary fields and researchers on MMESE related topics will benefit from these proceedings."

World-wide migration has an unsettling effect on social structures, especially on aging populations and eldercare. This volume investigates how taken-for-granted roles are challenged, intergenerational relationships transformed, economic ties recalibrated, technological innovations utilized, and spiritual relations pursued and desired, and asks what it means to care at a distance and to age abroad. What it does show is that trans-nationalization of care produces unprecedented convergences of people, objects and spaces that challenge our assumptions about the who, how, and where of care.

In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.

As functional genomics has become one of the major focuses in molecular biology, the need for more sophisticated tools to assist in the identification of the functionality of undefined genes and the correlation of DNA variants with a particular phenotype has increased greatly. In Silico Tools for Gene Discovery collects many common and useful in silico tools available today. The volume begins by investigating locus mapping information on linkage analysis, association mapping, integrative analysis, and exome analysis as well as tools for DNA marker selection, in silico PCR, and statistical analysis. It continues with a section on gene discovery from a defined locus, including gene prioritization, knowledge tracking, and data mining, and concludes with several useful in silico tools presented for the functional characterization of genes, which include DNA sequencing analysis, variant characterization, as well as RNA and protein analysis. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, step-by-step, readily reproducible protocols, and vital notes on troubleshooting and avoiding known pitfalls. Resourceful and easy to follow, In Silico Tools for Gene Discovery seeks to facilitate scientists with further key research on locus mapping, to accelerate gene identification, and to help ascertain the functionality of DNA variation.

Crash Course: Muscles, Bones and Skin focuses on the essential information you really need to know about the basic sciences of muscles, bones and skin. Each component is considered in an integrated format, putting the basic sciences in clinical context. Provides the exam syllabus in one place! Written by senior medical students or junior doctors - authors who really understand today's exam situation! Senior Faculty Advisors ensure complete accuracy of the text! Full artwork programme, improved 'Hints and Tips' boxes, and 'Clinical Application' boxes help you remember the key points! Self-Assessment section - fully updated to reflect new curriculum requirements - helps you maximise your grade! Solid, accurate, user-friendly coverage provides enough detail even for those aiming at distinction! Crash Course - the revision aid to get you the results you want! Crash Course is a complete revision guide designed specifically to save you time by providing everything you could be asked in the exam in one place. Each book in the series has been specially written either by senior medical students or junior doctors - carefully supervised by faculty advisors - to ensure that it exactly matches your needs by having been prepared by someone who has just been in the exam situation. Fully updated with improved layout, this volume provides the essential concepts of muscle, bone and skin in a memorable, easy-to-understand format. Complex information is provided succinctly and is accompanied by a full artwork programme thereby giving ready access to these related subject areas. A discussion of common problems in rheumatology, orthopaedics and dermatology adds relevance to the underlying physiological concepts explored while clinical assessment and examination, common skills and further investigations complete the picture. Additional features include 'Learning Objectives' at the start of each chapter, improved 'Hints and Tips' boxes, 'Clinical Application' boxes and a completely revised self-assessment section tailored to current exam needs. Take the stress out of study with Crash Course - the easier way to achieve exam success!

International Review of Cytology presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. This volume features articles on Molecular mechanism of liver development and regeneration; Molecular basis of vertebrate endoderm development; YidC as an essential and multifunctional component in membrane protein assembly; Mitotic spindle dynamics in Drosophila; and Neurogenesis in the Fish Retina.

"International Review of Cytology" presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include LEM-domain Proteins: New Insights into lamin-interacting Proteins; New Insights into Membrane Trafficking and Protein Sorting; Structure and Function of the Atypical Orphan Nuclear Receptor; Zebrafish Gastrulation: Cell Movements, Signals and Mechanisms; Calcium Dynamics: Spatio-tempral Organization from the Subcellular to the Organ Level; New Technologies Used in the Study of Human Melanoma.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Joni Bentley's unique expertise is a direct result of being a qualified practitioner not only of the Alexander Technique but also of Classical dressage, stress management and functional medicine. It is a rare person who can combine all these areas in order to reveal a new and much needed holistic dimension in the training of horse and rider. In "Riding Success Without Stress", the author demonstrates with clarity and perception how incorrect habits and negativity can be eradicated at source and replaced with calmness, straightness and grace by the application of the Alexander Technique and the Classical school. This book demonstrates how the Alexander Technique training programme ensures that, by optimising the use of your own mind and body, you can optimise the use of your horse and ride to success completely without stress. This ground-breaking and revolutionary book provides invaluable and thought-provoking information for the benefit of all riders and their horses.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Fertility specialists are constantly looking for ways to improve the chances of pregnancy through IVF or other assisted reproductive techniques (ART). 'Adjuvant' or 'add-on' therapies are procedures or medications which are added to IVF treatment to try and improve the chances of success. This book is a practical guide to the use of adjuvants in infertility for clinicians and trainees. Divided into ten sections, the text begins with an overview of the rational for additional therapy in IVF. The next section examines different types of adjuvant therapy and their pros and cons. Topics include medical nutrition therapy, neutraceuticals, antioxidants, micronutrients, and reactive oxygen species. Each of the following sections covers adjuvant use for improving a specific fertility issue - PCOS, ovarian reserve, uterine blood flow, endometrial receptivity, embryo implantation, and male subfertility. The final sections discuss the impact of thyroid autoimmunity on the outcome of ART, and the use of surgery as an adjuvant in infertility. Key points Practical guide to the use of adjuvants in infertility Covers various types of adjuvant and their use for different fertility issues Includes discussion on surgery as an adjuvant Highly illustrated with clinical photographs and diagrams

Lymphomas are lymphoid malignancies derived from B or T lymphocytes, and their study has been and still is paradigmatic for many aspects of cancer research. Lymphoma: Methods and Protocols presents and discusses key methods that are used in lymphoma research, partly specific for lymphoma research but often adaptable to the study of other cancers. By covering a broad variety of methods used in lymphoma research, this book will be of interest not only for hematologists, hematopathologists, and immunologists but also for scientists interested in other fields of cancer research as well as human genetics. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Lymphoma: Methods and Protocols serves researchers studying human physiology with the ultimate goal of understanding and controlling these often terrible diseases.

Different technologies have been introduced to improve management of labor. To date there is no single text that aims at covering all these technologies that address different problems and issues in labor management. The book reviews new technologies and devices aimed to improve labor management and outcomes. These diverge between looking at a better way to use fetal heart rate monitors (that are used in 90% of labours); using new monitors to detect the <1% of babies that are damaged in labor and account for 99% of the medico-legal costs in labor; and early detection of non-progressive labors that complicate 30-50% of labors. This is the only book about all these technologies from the perspectives of new devices and technologies in labor.