This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Praise for the Series:
"The authority, originality, and editing of the review are first class."
--Nature
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
--Journal of the American Chemical Society

Key Features
* Respiratory metabolism in hyperthermophilic organisms
* Structure and stability of hyperstable proteins
* Thermostable DNA polymerases
* DNA stability and DNA binding proteins
* Hyperthermophiles and their heat-shock proteins

From the Reviews of the Previous Volumes
"The authority, originality, and editing of the reviews are first class."
-NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Published continuously since 1944, the" Advances in Protein Chemistry and Structural Biology" serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This eclectic volume features articles on a variety of topical subjects.

Includes new information about protocols and analysis of proteins Eclectic volume presents chapters by a wide range ofleading experts Presents new, cutting-edge information that will serve as an essential addition to any bookshelf or laboratory "