This volume commemorates the 50th anniversary of the appearance in
Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he
"laid down" the foundations of linkage thermodynamics. Experts in
this area contribute articles on the state-of-the-art of this
important field and on new developments of the original theory.
Among the topics covered in this volume are electrostatic
contributions to molecular free energies in solution; site-specific
analysis of mutational effects in proteins; allosteric transitions
of the acetylcholine receptor; and deciphering the molecular code
of hemoglobin allostery.
General
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