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This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes.
This is the first compilation of protein lipidation enzymes. This
volume summarizes recent dramatic developments regarding enzymes
responsible for protein lipidation, a process critical for a number
of physiological functions, including cell proliferation and
morphology. Inhibitors of protein lipidation have recently been
shown to be useful as anticancer drugs. Enzymatic mechanisms,
mutational analysis, and structural studies are presented.
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