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Much has been written about reperfusion injury in the past decade
but unfortunately the information has been generally presented in
the form of original specialist papers and little if any integral
publication exists on the topic, summarising and analysing the
clinical impact of the condition and its management. The
pathophysiology and molecular mechanisms of reperfusion injury are
complex and, regarding diagnosis, individual diagnostic techniques
have been proposed but without a proper assessment of the relative
values of these methods. A publication dealing with integral
diagnostic strategies would be welcome by the managing physician.
Management of the condition is also problematic, as strategies that
appear to work in the experimental models do not translate into
beneficial interventions in patients. There is a need for these
issues to be addressed and discussed in a monographic fashion.
Management of Myocardial Reperfusion Injury will tackle these
issues in a modern and systematic way and the information will be
delivered in a fashion that will be appealing to the reader.
Ischemic Preconditioning: The Concept of Endogenous
Cardioprotection consolidates, in one volume, both current
knowledge and the most recent advances in ischemic preconditioning.
The editors have invited investigators at the forefront of ongoing
research to provide their scholarly and candid comments concerning
each of these issues. This volume includes a comprehensive review
of infarct size reduction with ischemic preconditioning, and the
most recent data on the effects of preconditioning on ischemia and
reperfusion-induced arrhythmias, myocardial metabolism, contractile
function, and the coronary vasculature. The role of altered energy
metabolism, stress-induced proteins, ATP-sensitive potassium
channels, and adenosine -- the major hypotheses that have been
proposed to explain the cardioprotective effects of ischemic
preconditioning -- are critically reviewed by investigators who
have been instrumental in developing these concepts. In addition,
the editors raise the intriguing possibility that ischemic
preconditioning may be more than simply a laboratory curiosity.
Using a multidisciplinary approach, this volume challenges the
readers to contribute their own expertise to address the unanswered
questions concerning this endogenous, cardioprotective phenomenon.
Interest in the ability of myocardium to adapt to ischaemic stress
has continued to grow since the discovery of ischaemic
preconditioning in 1986. In 1993, two reports heralded the
recognition of a delayed preconditioning response in the heart, now
commonly known as the second window' of protection. Since then, a
number of studies have described the ability of delayed
preconditioning and related adaptive phenomena to protect against a
variety of pathologies in the ischaemic and reperfused myocardium.
Our understanding of the cellular mechanisms of sub-acute adaptive
cardioprotection has advanced considerably during this period. This
compilation of state-of-the-art reviews by those who have made
significant contributions to this field provides detailed and
critical analysis of this research, from molecular basis to
potential clinical relevance. The book aims to provide an
authoritative, comprehensive and thoroughly up-to-date overview for
scientists and clinicians engaged in, or observing, this
rapidly-developing area of heart research. It will also be of
interest to those engaged in research on other tissues where
ischaemia-reperfusion pathology is of major concern.
Much has been written about reperfusion injury in the past decade
but unfortunately the information has been generally presented in
the form of original specialist papers and little if any integral
publication exists on the topic, summarising and analysing the
clinical impact of the condition and its management. The
pathophysiology and molecular mechanisms of reperfusion injury are
complex and, regarding diagnosis, individual diagnostic techniques
have been proposed but without a proper assessment of the relative
values of these methods. A publication dealing with integral
diagnostic strategies would be welcome by the managing physician.
Management of the condition is also problematic, as strategies that
appear to work in the experimental models do not translate into
beneficial interventions in patients. There is a need for these
issues to be addressed and discussed in a monographic fashion.
Management of Myocardial Reperfusion Injury will tackle these
issues in a modern and systematic way and the information will be
delivered in a fashion that will be appealing to the reader.
The ATP-sensitive potassium channel (KATP) was discovered in 1983.
Since then, an enormous amount of research has been undertaken to
characterize it in detail. This volume consolidates both the
current knowledge and most recent advances on the subject, and its
relationship to myocardial protection. To this end, the editors
have assembled investigators at the forefront of ongoing basic and
clinical research to provide scholarly and candid comments
concerning each of the pertinent issues, including: a comprehensive
review of the biology of the channel with respect to the
structure-activity relationship as well as overall chemistry of the
channel; the role of opening this channel and its effect on smooth
muscle (covering both the effects on myocardial stunning and its
ability to protect against myocardial infarction); the relationship
of KATP channel opening and the protection to the myocardium
afforded by the phenomenon of ischemic preconditioning; the
relationship between the KATP channel and electrophysiological
consequences with specific reference to arrhythmogenicity; and the
clinical implications of the use of agents that mimic the opening
of this channel, with reference to its protective nature and its
use in the treatment of angina. Audience: Clinicians and basic
scientists who have a direct interest in the KATP channel as well
as those groups who are interested in the entire concept of
myocardial protection and its relationship to academic and clinical
medicine.
Interest in the ability of myocardium to adapt to ischaemic stress
has continued to grow since the discovery of ischaemic
preconditioning in 1986. In 1993, two reports heralded the
recognition of a delayed preconditioning response in the heart, now
commonly known as the second window' of protection. Since then, a
number of studies have described the ability of delayed
preconditioning and related adaptive phenomena to protect against a
variety of pathologies in the ischaemic and reperfused myocardium.
Our understanding of the cellular mechanisms of sub-acute adaptive
cardioprotection has advanced considerably during this period. This
compilation of state-of-the-art reviews by those who have made
significant contributions to this field provides detailed and
critical analysis of this research, from molecular basis to
potential clinical relevance. The book aims to provide an
authoritative, comprehensive and thoroughly up-to-date overview for
scientists and clinicians engaged in, or observing, this
rapidly-developing area of heart research. It will also be of
interest to those engaged in research on other tissues where
ischaemia-reperfusion pathology is of major concern.
The ATP-sensitive potassium channel (KATP) was discovered in 1983.
Since then, an enormous amount of research has been undertaken to
characterize it in detail. This volume consolidates both the
current knowledge and most recent advances on the subject, and its
relationship to myocardial protection. To this end, the editors
have assembled investigators at the forefront of ongoing basic and
clinical research to provide scholarly and candid comments
concerning each of the pertinent issues, including: a comprehensive
review of the biology of the channel with respect to the
structure-activity relationship as well as overall chemistry of the
channel; the role of opening this channel and its effect on smooth
muscle (covering both the effects on myocardial stunning and its
ability to protect against myocardial infarction); the relationship
of KATP channel opening and the protection to the myocardium
afforded by the phenomenon of ischemic preconditioning; the
relationship between the KATP channel and electrophysiological
consequences with specific reference to arrhythmogenicity; and the
clinical implications of the use of agents that mimic the opening
of this channel, with reference to its protective nature and its
use in the treatment of angina. Audience: Clinicians and basic
scientists who have a direct interest in the KATP channel as well
as those groups who are interested in the entire concept of
myocardial protection and its relationship to academic and clinical
medicine.
Ischemic Preconditioning: The Concept of Endogenous
Cardioprotection consolidates, in one volume, both current
knowledge and the most recent advances in ischemic preconditioning.
The editors have invited investigators at the forefront of ongoing
research to provide their scholarly and candid comments concerning
each of these issues. This volume includes a comprehensive review
of infarct size reduction with ischemic preconditioning, and the
most recent data on the effects of preconditioning on ischemia and
reperfusion-induced arrhythmias, myocardial metabolism, contractile
function, and the coronary vasculature. The role of altered energy
metabolism, stress-induced proteins, ATP-sensitive potassium
channels, and adenosine -- the major hypotheses that have been
proposed to explain the cardioprotective effects of ischemic
preconditioning -- are critically reviewed by investigators who
have been instrumental in developing these concepts. In addition,
the editors raise the intriguing possibility that ischemic
preconditioning may be more than simply a laboratory curiosity.
Using a multidisciplinary approach, this volume challenges the
readers to contribute their own expertise to address the unanswered
questions concerning this endogenous, cardioprotective phenomenon.
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