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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Myocardial Protection and the KATP Channel (Hardcover, 1995 ed.)
Loot Price: R4,237
Discovery Miles 42 370
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Myocardial Protection and the KATP Channel (Hardcover, 1995 ed.)
Series: Developments in Cardiovascular Medicine, 179
Expected to ship within 10 - 15 working days
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The ATP-sensitive potassium channel (KATP) was discovered in 1983.
Since then, an enormous amount of research has been undertaken to
characterize it in detail. This volume consolidates both the
current knowledge and most recent advances on the subject, and its
relationship to myocardial protection. To this end, the editors
have assembled investigators at the forefront of ongoing basic and
clinical research to provide scholarly and candid comments
concerning each of the pertinent issues, including: a comprehensive
review of the biology of the channel with respect to the
structure-activity relationship as well as overall chemistry of the
channel; the role of opening this channel and its effect on smooth
muscle (covering both the effects on myocardial stunning and its
ability to protect against myocardial infarction); the relationship
of KATP channel opening and the protection to the myocardium
afforded by the phenomenon of ischemic preconditioning; the
relationship between the KATP channel and electrophysiological
consequences with specific reference to arrhythmogenicity; and the
clinical implications of the use of agents that mimic the opening
of this channel, with reference to its protective nature and its
use in the treatment of angina. Audience: Clinicians and basic
scientists who have a direct interest in the KATP channel as well
as those groups who are interested in the entire concept of
myocardial protection and its relationship to academic and clinical
medicine.
General
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