The amount of information that can be obtained by using molecular techniques in evolution, systematics and ecology has increased exponentially over the last ten years. The need for more rapid and efficient methods of data acquisition and analysis is growing accordingly. This manual presents some of the most important techniques for data acquisition developed over the last years. The choice and justification of data analysis techniques is also an important and critical aspect of modern phylogenetic and evolutionary analysis and so a considerable part of this volume addresses this important subject. The book is mainly written for students and researchers from evolutionary biology in search for methods to acquire data, but also from molecular biology who might be looking for information on how data are analyzed in an evolutionary context. To aid the user, information on web-located sites is included wherever possible. Approaches that will push the amount of information which systematics will gather in the

The human species is very young, but in a short time it has acquired some striking, if biologically superficial, variations across the planet. As this book shows, however, none of those biological variations can be understood in terms of discrete races, which do not actually exist as definable entities. Starting with a consideration of evolution and the mechanisms of diversification in nature, this book moves to an examination of attitudes to human variation throughout history, showing that it was only with the advent of slavery that considerations of human variation became politicized. It then embarks on a consideration of how racial classifications have been applied to genomic studies, demonstrating how individualized genomics is a much more effective approach to clinical treatments. It also shows how racial stratification does nothing to help us understand the phenomenon of human variation, at either the genomic or physical levels.

Phylogenomics: A Primer, Second Edition is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them.

First Published in 2005. Routledge is an imprint of Taylor & Francis, an informa company.

Invertebrate Zoology: A Tree of Life Approach is a comprehensive and authoritative textbook adopting an explicitly phylogenetic organization. Most of the classical anatomical and morphological work has not been changed - it established the foundation of Invertebrate Zoology. With the explosion of Next-Generation Sequencing approaches, there has been a sea-change in the recognized phylogenetic relationships among and between invertebrate lineages. In addition, the merger of evolutionary and developmental biology (evo-devo) has dramatically contributed to changes in the understanding of invertebrate biology. Synthesizing these three approaches (classical morphology, sequencing data, and evo-devo studies) offers students an entirely unique perspective of invertebrate diversity. Key Features One of the first textbooks to combine classical morphological approaches and newer evo-devo and Next-Generation Sequencing approaches to address Invertebrate Zoology Organized along taxonomic lines in accord with the latest understanding of invertebrate phylogeny Will provide background in basic systematic analysis useful within any study of biodiversity A wealth of ancillary materials for students and teachers, including downloadable figures, lecture slides, web links, and phylogenetic data matrices

Important practical implications are established by case reports and specific examples. The present book is the ideal complement to the practitioner 's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkh user MTBM book series.

The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels. The second part discusses DNA multiple sequence alignment, species designations using molecular data, evo-devo and other topics that are problematic or controversial. In the last part, novel topics in molecular evolution and systematics, like genomics, comparative methods in molecular evolution and the use of large data bases are described. The final chapter deals with problems in bacterial evolution, considering the increasing access to large numbers of complete genome sequences.

This volume offers readers an opportunity to learn about how genomes are sequenced, what discoveries have so far come out of this scientific revolution, and about the ethical dimensions of this advancing technology. The revised edition focuses on the new advances in genome technology and builds upon the strong basic biological format that was established in the original publication. It also takes advantage of the recent major advances in genome level sequencing and analysis to demonstrate the vast increase in biological knowledge over the past decade.

Phylogenomics: A Primer, Second Edition is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them.

Contents:
Introduction: Strange Resistances
1. Thomas Hardy: The Broken Lyre
2. Wallace Stevens: A Foreign Song
3. Philip Larkin: Rather than Words
4. Sylvia Plath: The Stars' Dark Address
5. Louise Glück: I was Here
6. Conclusion: Other Ends of the Mind

This book describes contemporary clinical practice in the application of neurosurgical methods to the treatment of psychiatric disorders. It covers diverse topics such as neuroimaging, ethics and a historical review, Gamma Knife and High Frequency Ultrasound ablation, deep brain electrical stimulation and preoperative evaluation and postoperative follow-up. Its application in Obsessive Compulsive Disorder, Major Depression, Tourette syndrome, Addiction, Anorexia, Aggression and Schizophrenia are discussed in separated chapters. This book presents concise information provided by clinical and academic practitioners and will facilitate the application of neurosurgical treatment techniques to patients.

Invertebrate Zoology: A Tree of Life Approach is a comprehensive and authoritative textbook adopting an explicitly phylogenetic organization. Most of the classical anatomical and morphological work has not been changed - it established the foundation of Invertebrate Zoology. With the explosion of Next-Generation Sequencing approaches, there has been a sea-change in the recognized phylogenetic relationships among and between invertebrate lineages. In addition, the merger of evolutionary and developmental biology (evo-devo) has dramatically contributed to changes in the understanding of invertebrate biology. Synthesizing these three approaches (classical morphology, sequencing data, and evo-devo studies) offers students an entirely unique perspective of invertebrate diversity. Key Features One of the first textbooks to combine classical morphological approaches and newer evo-devo and Next-Generation Sequencing approaches to address Invertebrate Zoology Organized along taxonomic lines in accord with the latest understanding of invertebrate phylogeny Will provide background in basic systematic analysis useful within any study of biodiversity A wealth of ancillary materials for students and teachers, including downloadable figures, lecture slides, web links, and phylogenetic data matrices

A star curator at the American Museum of Natural History widens the palette and shows how the physical, natural, and cultural context of color are inextricably tied to what we see right before our eyes. Is color a phenomenon of science or a thing of art? Over the years, color has dazzled, enhanced, and clarified the world we see, embraced through the experimental palettes of painting, the advent of the color photograph, Technicolor pictures, color printing, on and on, a vivid and vibrant celebrated continuum. These turns to represent reality in "living color" echo our evolutionary reliance on and indeed privileging of color as a complex and vital form of consumption, classification, and creation. It's everywhere we look, yet do we really know much of anything about it? Finding color in stars and light, examining the system of classification that determines survival through natural selection, studying the arrival of color in our universe and as a fulcrum for philosophy, DeSalle's brilliant A Natural History of Color establishes that an understanding of color on many different levels is at the heart of learning about nature, neurobiology, individualism, even a philosophy of existence. Color and a fine tuned understanding of it is vital to understanding ourselves and our consciousness.

In the last 25 years, we have witnessed a revolution in the way that ecologists and evolutionary biologists approach their disciplines. This revolution has been fueled by the ability to dissect the genetic and molecular basis of variation that is partly the currency of these disci- plines. Using modern molecular techniques, we have begun to restruc- ture the spectrum of questions that can be addressed in studying the mechanisms and consequences of the ecology and evolution of living organisms. The molecular revolution has co me in waves, so to speak, with three particularly important developments. The first concerns the establish- ment and widespread use of pro tein analysis. Microcomplement fixation and isozyme e1ectrophoresis were the techniques around which much of the genetic work in ecology and evolution were once based. The next wave started with the development of recombinant DNA technology and centered around the use of restriction fragment length polymor- phisms (RFLPs) and sequencing of DNAs cloned in bacteria. This technology was the first to actually examine and accumulate genetic information at the nucleotide level. The most recent wave of technology that we are currently experiencing is based on our ability to amplify DNA sequences enzymatically via the Polymerase Chain Reaction (PCR). Several techniques re1ated to PCR have been developed and used extensively in ecological and evolutionary studies.

Four years ago we edited a volume of 36 papers entitled Molecular Approaches to Ecology and Evolution (Schierwater et ai., 1994), in which we attempted to put to gether a diverse array of papers that demonstrated the impact that the technologi cal revolution ofmolecular biology has had on the field ofevolutionary biologyand ecology. The present volume borrows from that theme but attempts to focus more sharply on the impact that molecular biology has had on our understanding of dif ferent hierarchical levels important in evolutionary and ecological studies. Because DNA sequence variation is at the heart ofeverypaper in the present volume, we feel it necessary to examine how DNA has affected study at various levels of biological organization. The majority of the chapters in the present volume follow themes es tablished in the earlier volume; all chapters by authors in the previous volume are either fully updated or entirely new and expand into areas that we felt were impor tant for a more complete understanding of the impact of DNA technology on ecol ogy and evolution. The collection of papers in this volume cover a diverse array of ecological and evolutionary questions and demonstrates the breadth of coverage molecular tech nology has imparted on modern evolutionary biology. There are also a broad range of hierarchical questions approached by the 17 papers in this volume."

The human species is very young, but in a short time it has acquired some striking, if biologically superficial, variations across the planet. As this book shows, however, none of those biological variations can be understood in terms of discrete races, which do not actually exist as definable entities. Starting with a consideration of evolution and the mechanisms of diversification in nature, this book moves to an examination of attitudes to human variation throughout history, showing that it was only with the advent of slavery that considerations of human variation became politicized. It then embarks on a consideration of how racial classifications have been applied to genomic studies, demonstrating how individualized genomics is a much more effective approach to clinical treatments. It also shows how racial stratification does nothing to help us understand the phenomenon of human variation, at either the genomic or physical levels.

The amount of information that can be obtained by using molecular techniques in evolution, systematics and ecology has increased exponentially over the last ten years. The need for more rapid and efficient methods of data acquisition and analysis is growing accordingly. This manual presents some of the most important techniques for data acquisition developed over the last years. The choice and justification of data analysis techniques is also an important and critical aspect of modern phylogenetic and evolutionary analysis and so a considerable part of this volume addresses this important subject. The book is mainly written for students and researchers from evolutionary biology in search for methods to acquire data, but also from molecular biology who might be looking for information on how data are analyzed in an evolutionary context. To aid the user, information on web-located sites is included wherever possible. Approaches that will push the amount of information which systematics will gather in the

A celebration of beer-its science, its history, and its impact on human culture "Curatorial eminences Rob DeSalle and Ian Tattersall serve up a potent scientific brew. . . . A marvellous paean to the pint, and to the researchers probing its depths."-Barbara Kiser, Nature "Forced to choose between this book and a pint of hazy IPA, I would be at a loss. Better to consume them at the same time-both will go down easily, and leave you in an improved condition."-Bill McKibben What can beer teach us about biology, history, and the natural world? From ancient Mesopotamian fermentation practices to the resurgent American craft brewery, Rob DeSalle and Ian Tattersall peruse the historical record and traverse the globe for engaging and often surprising stories about beer. They explain how we came to drink beer, what ingredients combine to give beers their distinctive flavors, how beer's chemistry works at the molecular level, and how various societies have regulated the production and consumption of beer. Drawing from such diverse subject areas as animal behavior, ecology, history, archaeology, chemistry, sociology, law, genetics, physiology, neurobiology, and more, DeSalle and Tattersall entertain and inform with their engaging stories of beer throughout human history and the science behind it all. Readers are invited to grab a beer and explore the fascinating history of its creation.

Tackling one of the most difficult and delicate of the evolutionary questions, this challenging book summarizes the more recent results in phylogenetics and developmental biology that address the evolution of key innovations in metazoans. Divided into three sections, the first considers the phylogenetic issues involving this area of the tree of life and the elucidation of those relationships that continue to trouble taxonomists. The second section considers the developmental biology of metazoan evolution including the development of the nervous system, sensory organs, and physiological maturation. Part three focuses on the evolution of pattern and process in the Metazoa.

"The origin of multicellular animals is one of those difficult and delicate biological problems that have been pondered for centuries. This book summarizes recent results in phylogenetics and developmental biology that address the evolution of key innovations in metazoans. The first section covers phylogenetic issues. Focusing on nervous system and sensory organ development, the second section addresses prominent questions concerning the developmental biology of metazoan evolution. A third section discusses the evolution of pattern and process in the incredible forms of life that we call Metazoa and covers evolution of life histories and the evolution of biogeochemical aspects of metazoans. The book has over 40 illustrations and an up-to-date bibliography of over 500 references. Each chapter concludes with a set of questions for study and discussion."--

Revolutionary research is revealing how the trillions of microbes living on and in our bodies can keep us healthy . . . or make us sick Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine. Rob DeSalle and Susan Perkins illuminate the long, intertwined evolution of humans and microbes. They discuss how novel DNA sequencing has shed entirely new light on the complexity of microbe-human interactions, and they examine the potential benefits to human health: amazing possibilities for pinpoint treatment of infections and other illnesses without upsetting the vital balance of an individual microbiome. This book has been inspired by an exhibition, The Secret World Inside You: The Microbiome, at the American Museum of Natural History, which will open in New York in early November 2015 and run until August 2016. It will then travel to other museums in the United States and abroad.

When you think of evolution, the picture that most likely comes to mind is a straight-forward progression, the iconic illustration of a primate morphing into a proud, upright human being. But in reality, random events have played huge roles in determining the evolutionary histories of everything from lions to lobsters to humans. However, random genetic novelties are most likely to become fixed in small populations. It is mathematically unlikely that this will happen in large ones. With our enormous, close-packed, and seemingly inexorably expanding population, humanity has fallen under the influence of the famous (or infamous) "bell curve." Ian Tattersall and Rob DeSalle's revelatory new book explores what the future of our species could hold, while simultaneously revealing what we didn't become-and what we won't become. A cognitively unique species, and our actions fall on a bell curve as well. Individual people may be saintly or evil; generous or grasping; narrow-minded or visionary. But any attempt to characterize our species must embrace all of its members and so all of these antitheses. It is possible not just for the species, but for a single individual to be all of these things-even in the same day. We all fall somewhere within the giant hyperspace of the human condition that these curves describe. The Accidental Homo Sapiens shows readers that though humanity now exists on this bell curve, we are far from a stagnant species. Tattersall and DeSalle reveal how biological evolution in modern humans has given way to a cultural dynamic that is unlike anything else the Earth has ever witnessed, and that will keep life interesting-perhaps sometimes too interesting-for as long as we exist on this planet.

Important practical implications are established by case reports and specific examples. The present book is the ideal complement to the practitioner s manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhauser MTBM book series.

The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels. The second part discusses DNA multiple sequence alignment, species designations using molecular data, evo-devo and other topics that are problematic or controversial. In the last part, novel topics in molecular evolution and systematics, like genomics, comparative methods in molecular evolution and the use of large data bases are described. The final chapter deals with problems in bacterial evolution, considering the increasing access to large numbers of complete genome sequences."

This issue of Neurosurgery Clinics of North America is devoted to "Advances in Neuromodulation." Editors Won Kim, MD, Antonio De Salles, MD, and Nader Pouratian, MD have assembled the top experts to review topics such as: peripheral nerve stimulation; spinal cord stimulation for gait reanimation and vascular pathology; deep brain stimulation for Tourettes, OCD, depression, Parkinson's disease, eating disorders, dystonia, and headache; and techniques for image-guided deep brain stimulation, advanced imaging for targeting, and closed loop neuromodulation.

An imaginative natural history survey of the wide world of spirits, from whiskey and gin to grappa and moonshine In this follow-up book to A Natural History of Wine and A Natural History of Beer, authors Rob DeSalle and Ian Tattersall yet again use alcoholic beverages as a lens through which to gain a greater appreciation of natural history. This volume considers highly alcoholic spirits in the context of evolution, ecology, history, primatology, molecular biology, physiology, neurobiology, chemistry, and even astrophysics. With the help of illustrator Patricia Wynne, DeSalle and Tattersall address historical and cultural aspects and ingredients, the distillation process, and spirits and their effects. They also call on an international group of colleagues to contribute chapters on brandy, vodka, tequila, whiskies, gin, rum, eaux-de-vie, schnapps, baiju, grappa, ouzo, and cachaca. Covering beverages from across the globe and including descriptions of the experience of tasting each drink, this book offers an accessible and comprehensive exploration of the scientific dimensions of spirits.