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The articles in this volume have been selected to demonstrate the
progress in the development of human antibody therapeutics for
viral disease. Keck et al. review the nature of the immune response
to the Hepatitis C virus (HCV) and the details of viral
neutralization by antibodies, providing a conceptual model for the
clinical use of HCV-specific antibodies. Huber et al. summarize the
initial clinical experiences with antibody therapeutics for Human
Immunodeficiency Virus that can be targeted to either the HIV
virion or to host cell proteins. A discussion of the breadth immune
strategies that is required to control human rabies is provided by
Nagarajan et al., with a particular focus on India and other
countries in which rabies is endemic. The development of
pavilizumab for RSV prophylaxis is reviewed in Wu et al., in
addition to results of antibody optimization studies that provide
surprising insights and have broad general implications for
anti-viral antibody engineering. Melhop and Diamond explicate the
biology of West Nile Virus as a general model for flaviviruses,
while using their cloned antibodies as a springboard to consider
the mechanisms of WNV neutralization. The volume concludes with a
description of methods to clone human antibodies in their native
configurations, which access a class of antibodies that differ from
those obtained by recombinant DNA or transgenic mouse methods. The
articles in this volume are definitive and comprehensive reviews
written by experts who have sought to define the principles of
viral neutralization by human antibodies. They explore and
anticipate the obstacles and opportunities that will be encountered
as the power of human antibodies is harnessed to address the vast,
un-met need for effective anti-viral therapeutics.
Preserving the Promise: Improving the Culture of Biotech Investment
critically examines why most biotech startups fail, as they emerge
from universities into an ecosystem that inhibits rather than
encourages innovation. This "Valley of Death" squanders our public
investments in medical research and with them, the promise of
longer and healthier lives. The authors explicate the Translation
Gap faced by early stage biotech companies, the result of
problematic technology transfer and investment practices, and
provide specific prescriptions for improving translation of
important discoveries into safe and effective therapies. In
Preserving the Promise, Dessain and Fishman build on their
collective experience as company founders, healthcare investor
(Fishman) and physician/scientist (Dessain). The book offers a
forward-looking, critical analysis of "conventional wisdom" that
encumbers commercialization practices. It exposes the
self-defeating habits of drug development in the Valley of Death,
that waste money and extinguish innovative technologies through
distorted financial incentives.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Des Causes De La Depopulation Et Des Moyens D'y Remedier
Pierre Jaubert, Dessain Dessain, 1767 History; Europe; France;
History / Europe / France
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