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The establishment of precise and reliable biomarker tests for the
early stages of cardiovascular disease is of great importance and
can be the cornerstone in the prevention of future cardiovascular
disease (CVD). Furthermore, some biomarkers may provide important
information concerning the pathogenesis of CVD or appear to be
useful in risk stratification, in CVD diagnosis, or in monitoring
therapy; many others may be risk factors themselves, representing
therefore potential targets of therapy. The ideal biomarker should
have the following characteristics: highly sensitive, specific,
reliable, accessible, standardized, dependable, cost effective, and
easily interpretable by clinicians. The present book focuses on the
presentation and evaluation of the most promising classical and
novel biochemical markers used in CVD (coronary artery disease,
hypertension, heart failure, hyperlipidemia, peripheral arterial
disease). The underlying pathophysiological characteristics of each
biomarker, as well as potential clinical implications in daily
practice are reviewed in this book.
The establishment of precise and reliable biomarker tests for the
early stages of cardiovascular disease is of great importance and
can be the cornerstone in the prevention of future cardiovascular
disease (CVD). Furthermore, some biomarkers may provide important
information concerning the pathogenesis of CVD or appear to be
useful in risk stratification, in CVD diagnosis, or in monitoring
therapy; many others may be risk factors themselves, representing
therefore potential targets of therapy. The ideal biomarker should
have the following characteristics: highly sensitive, specific,
reliable, accessible, standardized, dependable, cost effective, and
easily interpretable by clinicians. The present book focuses on the
presentation and evaluation of the most promising classical and
novel biochemical markers used in CVD (coronary artery disease,
hypertension, heart failure, hyperlipidemia, peripheral arterial
disease). The underlying pathophysiological characteristics of each
biomarker, as well as potential clinical implications in daily
practice are reviewed in this book.
Coronary Artery Disease: From Biology to Clinical Practice links
the most important basic concepts of atherosclerosis
pathophysiology to treatment management of coronary artery disease.
Comprehensive coverage starts with the basic pathophysiologic
mechanisms of the disease, including molecular and genetic
mechanisms, cells interaction and inflammation. In addition,
sections on novel anti-atherosclerotic therapies and a thorough
understanding of the recent trends in clinical management round out
this comprehensive tome that is ideal for practitioners and
researchers. By summarizing this novel knowledge and changes in
diagnostic algorithm and treatment options, this is the perfect
reference for cardiology researchers who want a volume with the
most up-to-date experimental trends in the field of
atherosclerosis, for cardiologists and physicians who manage
patients with atherosclerotic risk factors and established coronary
artery disease, and medical students who want to learn the basic
concepts of atherosclerosis.
It is well established that the vascular endothelium consists of a
single layer of endothelial cells (ECs) that lines the entire
vascular system, which plays an important role in vascular
homeostasis, immune and inflammatory reactions. The endothelial
cells exert significant autocrine, paracrine and endocrine actions
and influence smooth muscle cells, platelets and peripheral
leucocytes. It represents an important barrier between the blood
and the underlying interstitium and cells and has a major role in
the regulation of vascular tone, producing several vasoactive
mediators. This book examines up-to-date research regarding the
role of endothelial functions in terms of atherosclerosis and its
clinical manifestations.
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