0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R2,500 - R5,000 (2)
  • R5,000 - R10,000 (2)
  • -
Status
Brand

Showing 1 - 4 of 4 matches in All Departments

Muscle Gene Therapy - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011): Dongsheng Duan Muscle Gene Therapy - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011)
Dongsheng Duan
R4,325 Discovery Miles 43 250 Ships in 10 - 15 working days

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body. In Muscle Gene Therapy: Methods and Protocols, expert researchers in the field present a collection of techniques aimed at bridging the translational gap in muscle gene therapy between the prevalent rodent models and vitally important larger animal models. Divided into three sections, this volume examines basic protocols for optimizing the muscle gene expression cassette and for evaluating the therapeutic outcomes, new developments in muscle gene therapy technology such as adeno-associated viral vector (AAV), oligonucleotide-mediated exon-skipping, and novel RNA-based strategies, and step-by-step guidance on muscle gene delivery in swine, ovine, canine, and non-human primates. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, detailed, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Muscle Gene Therapy: Methods and Protocols serves as an invaluable resource for graduate students, post-doctoral fellows, and principle investigators pursuing the crucial advancement of muscle disease gene therapy in the hope of someday curing these debilitating disorders.

Muscle Gene Therapy (Paperback, 2010 ed.): Dongsheng Duan Muscle Gene Therapy (Paperback, 2010 ed.)
Dongsheng Duan
R5,248 Discovery Miles 52 480 Ships in 10 - 15 working days

Muscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.

Muscle Gene Therapy - Methods and Protocols (Hardcover, Edition.): Dongsheng Duan Muscle Gene Therapy - Methods and Protocols (Hardcover, Edition.)
Dongsheng Duan
R3,060 Discovery Miles 30 600 Ships in 10 - 15 working days

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body. In Muscle Gene Therapy: Methods and Protocols, expert researchers in the field present a collection of techniques aimed at bridging the translational gap in muscle gene therapy between the prevalent rodent models and vitally important larger animal models. Divided into three sections, this volume examines basic protocols for optimizing the muscle gene expression cassette and for evaluating the therapeutic outcomes, new developments in muscle gene therapy technology such as adeno-associated viral vector (AAV), oligonucleotide-mediated exon-skipping, and novel RNA-based strategies, and step-by-step guidance on muscle gene delivery in swine, ovine, canine, and non-human primates. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, detailed, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Muscle Gene Therapy: Methods and Protocols serves as an invaluable resource for graduate students, post-doctoral fellows, and principle investigators pursuing the crucial advancement of muscle disease gene therapy in the hope of someday curing these debilitating disorders.

Muscle Gene Therapy (Hardcover, 2nd ed. 2019): Dongsheng Duan, Jerry R. Mendell Muscle Gene Therapy (Hardcover, 2nd ed. 2019)
Dongsheng Duan, Jerry R. Mendell
R8,759 Discovery Miles 87 590 Ships in 10 - 15 working days

About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Loot
Nadine Gordimer Paperback  (2)
R398 R330 Discovery Miles 3 300
Casio LW-200-7AV Watch with 10-Year…
R999 R884 Discovery Miles 8 840
Little Black Book
Brittany Murphy, Ron Livingston, … DVD  (2)
R35 Discovery Miles 350
Call The Midwife - Season 10
Jenny Agutter, Linda Bassett, … DVD R209 Discovery Miles 2 090
Loot
Nadine Gordimer Paperback  (2)
R398 R330 Discovery Miles 3 300
Marvel Spiderman Fibre-Tip Markers (Pack…
R57 Discovery Miles 570
Bostik Sew Simple (25ml)
R31 Discovery Miles 310
Dala Craft Pom Poms - Assorted Colours…
R36 Discovery Miles 360
Dunlop Pro High Altitude Squash Ball…
R180 R155 Discovery Miles 1 550
Mediabox NEO TV Stick (Black) - Netflix…
R1,189 Discovery Miles 11 890

 

Partners