Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches utilized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life itself, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become "the" reference work for GTPases.

The seventh Jerusalem Symposium has tried to penetrate into a field of research towards which the efforts of a large number of the most variegated modern techniques are conversing: molecular and quantum pharmacology. The hope to elucidate the mode of action of drugs, to establish correlations between the electronic and con formational structures of drugs and their mode of action and level of activity, to derive from these data the nature of the cellular receptors and an understanding of the interaction of the drugs with those receptors - is a strong stimulus to enlarge and deepen the research efforts with the ultimate view to rationalize the design of more efficient and more specific drugs. The Symposium represents an attempt to survey the progress made so far in this respect and the methods and efforts employed in order to arrive at even greater achievements. The presentation of this Symposium differs somewhat from that of the preceding ones. Owing to the political events which disturbed the peace in the Middle East and therefore the normal activities of commerce and industry in Israel at least temporarily, the printing and distribution of this volume were entrusted to the Reidel Publishing Company. We wish to thank them for their very efficient col1aboration and for all their efforts to publish this volume with a minimum delay."

COMPARED WITH the first five Jerusalem Symposia on Quantum Chemistry and Biochem istry, this sixth Symposium represents a step into a new and largely uncharted area: that of Chemical and Biochemical Reactivity. While the previous Symposia dealt principally with the 'static' data, describing molecules-even large ones-of chemical and biological in terest, the present Symposium attempts to deal with 'dynamic' phenomena and the factors which determine their course. The complexities of these systems and the ensuing theoreti cal (and experimental) difficulties are, obviously, much more pronounced. Nevertheless, we hope that the present volume of Proceedings makes a positive contribu tion to the very interesting field of Reactivity: the lively discussions which followed every paper seem to us a good indication that our hope is justified. As last year, we have includ ed in these Proceedings only those portions of the discussions which the participants themselves formulated in writing, and, of course, the replies given by the speakers, to whom we transmitted the written formulations. We must apologize to the participants in the Symposium for the long delay in publishing this volume. The October 1973 War, and, even more, its aftermath, made it impossible for us to produce the work by our scheduled date of April 1, 1974, as Israel's manpower, especially its technically skilled manpower, was not always free for its normal occupation."

The seventh Jerusalem Symposium has tried to penetrate into a field of research towards which the efforts of a large number of the most variegated modern techniques are conversing: molecular and quantum pharmacology. The hope to elucidate the mode of action of drugs, to establish correlations between the electronic and con formational structures of drugs and their mode of action and level of activity, to derive from these data the nature of the cellular receptors and an understanding of the interaction of the drugs with those receptors - is a strong stimulus to enlarge and deepen the research efforts with the ultimate view to rationalize the design of more efficient and more specific drugs. The Symposium represents an attempt to survey the progress made so far in this respect and the methods and efforts employed in order to arrive at even greater achievements. The presentation of this Symposium differs somewhat from that of the preceding ones. Owing to the political events which disturbed the peace in the Middle East and therefore the normal activities of commerce and industry in Israel at least temporarily, the printing and distribution of this volume were entrusted to the Reidel Publishing Company. We wish to thank them for their very efficient col1aboration and for all their efforts to publish this volume with a minimum delay."

In einer Besprechung eines der letzten Bande dieses Handbuches bemangelt ein Kritiker, da/3 das Erscheinen der einzelnen Bande sich zeitlich so weit hinaus ziehe, da/3 das Handbuch als Ganzes bei dem raschen Fortschritte der Forschung auf dem Gebiete der Speziellen Pathologie den Stand unseres Wissens in bezug auf die Organerkrankungen kaum mehr einheitlich darstelle. Dies ist richtig; aber gegenuber dieser Forderung ist zu sagen, da/3 das Handbuch sie nie zu erfullen beabsichtigt hat, schon aus dem einfachen Grunde, da/3 es technisch undurchfuhrbar gewesen ware, einen solchen Stoff binnen weniger Jahre zu bewaltigen; hinzukommt, da/3 mit wechselnden menschlichen Schicksalen und Arbeitsweisen gerechnet werden mu/3. Der Tod und manche andere Macht lichtet die Reihen der Mitarbeiter; der eine liefert punktlich seinen Beitrag, vom anderen ist er nach 20 Jahren noch nicht zu erhalten. Aber man darf ein solches Werk auch nicht allein vom Standpunkt des gegenwartigen Bedurfnisses ansehen. Auch wenn sich seine Herausgabe, wie vorauszusehen in einer Zeit wie der unsrigen, uber P/2 Jahrzehnte hinauszieht, so ist diese Zeitspanne fUr ein Werk nicht zu viel, das die Aufgabe hat und wohl auch erfullt, den Stand unserer Wissenschaft auf lange Zeit hinaus zusammen zufassen. Ich weiB, welchen Muhen sich OTTO LUBARSCH, mein Vorganger im Amt und in der Herausgabe dieses Handbuches, mit der Schriftleitung unter zogen hat und welches Verdienst ihm gerade in der Hinsicht einer moglichsten Beschleunigung des Erscheinens zukommt."

Dieses Buch ist aus Skripten der Autoren zu ihrer Vorlesung "Mathe- matische Logik (fUr Informatiker)" entstanden. Diese sechssttindige Lehrveranstaltung, die seit dem Sommersemester 1974 jahrlich an der Technischen Universitat Berlin im Fachbereich Informatik ab- gehalten wird, will Informatik-Studenten etwa yom 4. Semester an mit Logik-Methoden vertraut machen und gleichzeitig einen" Bei- trag zur Mathematik-Ausbildung fUr Informatiker leisten. Dement- sprechend handelt es sich urn einen einfUhrenden Text fUr "krasse" Anfanger in der Logik, der mit elementaren Mathematik -Kenntnissen lesbar ist und an Informatik-Voraussetzungen nur einfachste Kon- zepte von Programmiersprachen benotigt. Anliegen des Buches, das sich gleichermaBen an Mathematik- und Informatik-Studenten wen- det, ist es, einerseits eine mathematisch zufriedenstellende Darstellung der Anfangsgrtinde der Pradikatenlogik der ersten Stufe zu geben, andererseits aber auch Anwendungen dieser Logik innerhalb der Informatik einheitlich in die Logik-Darstellung einzubeziehen. Der Versuch, ein Buch tiber Logik mit Informatik-Anwendungen zu schreiben, ist nicht ohne Probleme, da die Auswahl der Verbin- dungen von Logik und Informatik eine subjektive Entscheidung bleibt, so daB tiber den hier vorliegenden Text hinaus Raum fUr andere Bertihrungspunkte und fUr eine intensivere Gestaltung der hier im Text angefUhrten Anwendungen besteht. Man kann dabei z. B. an engere Verbindungen zur theoretischen Informatik denken oder an eine systematische Abhandlung der angesprochenen Anwen- dungsgebiete. Dieser Text will dazu anregen, Informatik und Lo- gik so aufeinander zu beziehen, daB Logik als Hilfsmittel fUr die Informatik angesehen werden darf, d. h. als eine fruchtbare, Infor- matik-Ergebnisse hervorbringende Methode.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfangen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen fur die historische wie auch die disziplingeschichtliche Forschung zur Verfugung, die jeweils im historischen Kontext betrachtet werden mussen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Our health system resembles a repair service which treats illness and suffering. But in many cases it would seem much simpler to avoid health problems. Why do we wait until the illnesses have developed? Young and expectant families are particularly interested in maintaining the health of their children and their whole family. Since prevention must begin long before the emergence of illness, there can be no better time to start than the beginning of life. This book presents a range of contributions that not only encourage theoretical reflection about the topics discussed but also provide practical suggestions.

Economic motivations are generally the major driving force for the formation of free trade agreements among countries, but there are other reasons countries enter into FTAs, including political and security factors. Trade agreements were also expected to improve investor confidence, attract foreign investment, and create jobs. Mexico may have other reasons for entering into FTAs, such as expanding market access and decreasing its reliance on the United States as an export market. This book provides an overview of the North American Free Trade Agreement, the current functions of the free trade agreement, and the effects of this agreement which have affected both countries over the last five years.