Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Much has happened since the first appearance of AIDS in 1981: it has been identified, studied, and occasionally denied. The virus has shifted host populations and spread globally. Medicine, the social sciences, and world governments have joined forces to combat and prevent the disease. And South Africa has emerged as ground zero for the pandemic.

The editors of "HIV/AIDS in South Africa 25 Years On" present the South African crisis as a template for addressing the myriad issues surrounding the epidemic worldwide, as the book brings together a widely scattered body of literature, analyzes psychosocial and sexual aspects contributing to HIV transmission and prevention, and delves into complex intersections of race, gender, class, and politics. Including largely overlooked populations and issues (e.g., prisoners, persons with disabilities, stigma), as well as challenges shaping future research and policy, the contributors approach their topics with rare depth, meticulous research, carefully drawn conclusions, and profound compassion. Among the topics covered:

The relationship between HIV and poverty, starting from the question, "Which is the determinant and which is the consequence?"

Epidemiology of HIV among women and men: concepts of femininity and masculinity, and gender inequities as they affect HIV risk; gender-specific prevention and intervention strategies.

The impact of AIDS on infants and young children: risk and protective factors; care of children by HIV-positive mothers; HIV-infected children.

Current prevention and treatment projects, including local-level responses, community-based work, and VCT (voluntary counseling and testing) programs.

New directions: promoting circumcision, vaccine trials, "positive prevention."

South Africa's history of AIDS denialism.

The urgent lessons in this book apply both globally and locally, making" HIV/AIDS in South Africa 25 Years On "uniquely instructive and useful for professionals working in HIV/AIDS and global public health.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

For 2,000 years the Christian churches have developed, disagreed with each other, and divided into separate and often hostile factions. This book, written by a distinguished Church historian, explores the theological lessons to be learnt from this difficult history.

The author identifies a recurring historic tendency to identify the Christian life with one or another specific means to holiness, such as ascetic discipline, martyrdom, or the cult of the Eucharist. He examines how historians of Christianity gradually came to terms with the idea that the Church could change, and even lapse into serious error. He also shows how historical perspective has played a key role in many of the most important theologies of the past 100 years. The book concludes that a living Christianity is never absolutely timeless, and that we can only ever perceive a facet of its total revelation, conditioned as we are by our own historical and cultural context.

For 2,000 years the Christian churches have developed, disagreed with each other, and divided into separate and often hostile factions. This book, written by a distinguished Church historian, explores the theological lessons to be learnt from this difficult history.The author identifies a recurring historic tendency to identify the Christian life with one or another specific means to holiness, such as ascetic discipline, martyrdom, or the cult of the Eucharist. He examines how historians of Christianity gradually came to terms with the idea that the Church could change, and even lapse into serious error. He also shows how historical perspective has played a key role in many of the most important theologies of the past 100 years. The book concludes that a living Christianity is never absolutely timeless, and that we can only ever perceive a facet of its total revelation, conditioned as we are by our own historical and cultural context.

This book provides the first full single-volume scholarly account in English of the "Waldenses" and examination of the concept of "Waldensianism" from the late 12th century to the Reformation. "Waldenses" is the name given to diverse and widely-scattered groups of religious dissenters since the time of the movement's reputed founder, a rich citizen of Lyon called Valdesius, in the late twelfth century. Though living within the culture of the Catholic Church, these people doubted the holiness of its priesthood and questioned its teachings about the destiny of souls after death.

The various strands of this movement emerged and endured over a long period of time. In consequence some earlier historians assumed, rather than demonstrated, that 'Waldensian' heresy remained one coherent phenomenon throughout its life-span. They also tended to neglect some of the transient or 'untypical' aspects of the movement.

This new book draws on primary sources to consider each of the manifestations of the movement in turn. It examines connections in space and time through correspondence and tradition between the different groups of Waldenses. It also asks what were the common threads in certain characteristics of religious practice, linking in differing degrees all the forms that the movement took.

Currently,there is no single source that permitscomparisonof the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our parti- lar system,missing outon theopportunityto de neunifyingthemesin viralgenome replication or bene t from the advances in other systems. For example, extraor- nary biologicaland experimentalparadigmsthat have been established overthe past 5 years for the DNA replication systems of bacteriophage T4 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the eld, as well as encourage students into this area of research. The monograph has been divided into eight parts. Chapters appearing in Parts I-VI are intended to compare and contrast the replication and/or transcription processes and corresponding "players" of the indicated family of viruses. We are interested in the sequence of events that lead to production of mRNA and progeny genomes as well as the cis-acting elements and trans-acting factors and enzymes (viral and cellular) that are required for these processes. Chapters appearing in Part VII are - tended to providea more biochemical and biophysicalperspective of the replication and/ortranscriptionprocess. Chaptersappearingin Part VIII are intendedto provide a practical perspective on viral replication and its inhibition.

Much has happened since the first appearance of AIDS in 1981: it has been identified, studied, and occasionally denied. The virus has shifted host populations and spread globally. Medicine, the social sciences, and world governments have joined forces to combat and prevent the disease. And South Africa has emerged as ground zero for the pandemic. The editors of HIV/AIDS in South Africa 25 Years On present the South African crisis as a template for addressing the myriad issues surrounding the epidemic worldwide, as the book brings together a widely scattered body of literature, analyzes psychosocial and sexual aspects contributing to HIV transmission and prevention, and delves into complex intersections of race, gender, class, and politics. Including largely overlooked populations and issues (e.g., prisoners, persons with disabilities, stigma), as well as challenges shaping future research and policy, the contributors approach their topics with rare depth, meticulous research, carefully drawn conclusions, and profound compassion. Among the topics covered: The relationship between HIV and poverty, starting from the question, "Which is the determinant and which is the consequence?" Epidemiology of HIV among women and men: concepts of femininity and masculinity, and gender inequities as they affect HIV risk; gender-specific prevention and intervention strategies. The impact of AIDS on infants and young children: risk and protective factors; care of children by HIV-positive mothers; HIV-infected children. Current prevention and treatment projects, including local-level responses, community-based work, and VCT (voluntary counseling and testing) programs. New directions: promoting circumcision, vaccine trials, "positive prevention." South Africa's history of AIDS denialism. The urgent lessons in this book apply both globally and locally, making HIV/AIDS in South Africa 25 Years On uniquely instructive and useful for professionals working in HIV/AIDS and global public health.

Hands On, Minds On describes the importance of children's foundational cognitive skills for academic achievement in literacy and mathematics, as well as their connections with other areas of school readiness, including physical health and social and emotional development. It also examines the growing evidence in favor of guided object play.

This heavily revised book features a variety of cases detailing potential complications in cardiac surgery. Clinical scenarios associated with conundrums and unforeseen circumstances are presented, including minimally invasive and hybrid procedures as well as temporary mechanical circulatory support. Discussions emphasize critical details in preoperative assessment and intraoperative sensemaking, decision making and error recovery. Chapters are structured as unknowns, presenting findings as one would experience the events clinically and challenging the reader to develop their own rescue strategies. Relevant references for further reading are included, enabling the reader to further develop their knowledge base. Near Misses in Cardiac Surgery is a concise case-based resource featuring instructions on how to deal with potential complications associated with cardiac surgery. The work's multi-disciplinary authorship ensures it is a valuable resource for all medical professionals involved in the care of cardiac surgical patients.

This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!