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Viral Genome Replication (Paperback, 2009 ed.)
Loot Price: R5,533
Discovery Miles 55 330
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Viral Genome Replication (Paperback, 2009 ed.)
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Currently,there is no single source that permitscomparisonof the
factors, elements, enzymes and/or mechanisms employed by different
classes of viruses for genome replication. As a result, we (and our
students) often restrict our focus to our parti- lar system,missing
outon theopportunityto de neunifyingthemesin viralgenome
replication or bene t from the advances in other systems. For
example, extraor- nary biologicaland experimentalparadigmsthat have
been established overthe past 5 years for the DNA replication
systems of bacteriophage T4 will likely be of great value to anyone
interested in studying a replisome from any virus. These studies
could easily go unnoticed by animal RNA and DNA virologists. It is
our hope that this monograph will cross-fertilize and invigorate
the eld, as well as encourage students into this area of research.
The monograph has been divided into eight parts. Chapters appearing
in Parts I-VI are intended to compare and contrast the replication
and/or transcription processes and corresponding "players" of the
indicated family of viruses. We are interested in the sequence of
events that lead to production of mRNA and progeny genomes as well
as the cis-acting elements and trans-acting factors and enzymes
(viral and cellular) that are required for these processes.
Chapters appearing in Part VII are - tended to providea more
biochemical and biophysicalperspective of the replication
and/ortranscriptionprocess. Chaptersappearingin Part VIII are
intendedto provide a practical perspective on viral replication and
its inhibition.
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