This book is based on the contributions to the IFAC-Workshop "Mass Spectro metry in Biotechnological Process Analysis and Control" held in Graz, Austria from 23 to 24 October 1986. The idea to organize this workshop and further to prepare these proceedings was stimulated by the following facts. Biotechnological processes urgently need better on-line instrumentation. Mass spectrometry (MS) offers a great potential to especially analyse gases and volatile compounds. It is, however, considered that this potential by far is not exhausted. The main reason for this is that MS often still is considered to be a very expensive technique requiring the permanent attention of a MS expert. In addition methods have not yet been developed to a user friendly state. On-line MS-methods are available to a certain extent, but need further development. To stimulate such development an interdisciplinary effort is necessary. Needs of industrial and university users and experience of physicists and instrument manufacturers have to be brought into a hopefully fruitful discussion. An introductory article describes the bioprocess background including a brief summary of the state of the art in bioprocess sensor and parameter estimation development, and the potential MS offers for bioprocess monitoring. In the first chapter on "Instrumentation and Gas Analysis" a general overview on some developments in MS-instrumentation is given initially by Schmid. Then the presently available instrumentation for bioprocess monitoring is discussed by instrument manufacturers (Winter; Schaefer and Schultis; Bartman)."

This book provides a framework for the development of sustainable bioprocesses. It includes methods for modeling and assessing both the economic and environmental aspects of biotechnological processes and illustrates their application in a series of case studies covering a broad range of products.

The book: provides, in four chapters, an introduction to bioproducts and bioprocesses and the unit operations involved in manufacturing, as well as bioprocess modeling in combination with economic and environmental assessment methods; cuts across multiple process industries, including pharmaceutical, biochemicals, chemicals and food production; addresses risk and uncertainty analysis which are particularly important in early process and product development; presents a unique set of case examples from various parts of biotechnology that improve the understanding of this technology and provide a starting point for developing a specific model.

The CD-ROM included contains the process models described in the text. All process model examples are implemented into SuperPro Designer a. The models are selected as characteristic examples of major bioprocess applications including bulk bio-chemicals, fine chemicals, enzymes, low and high molecular weight pharmaceuticals. Topics covered are: Citric Acid, Pyruvic Acid, L-Lysine, Riboflavin - Vitamin B2, α-Cyclodextrin, Penicillin V, Recombinant Human Serum Albumin, Recombinant Human Insulin; Monoclonal Antibodies, α-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures and Plasmid DNA production. These examples provide a hands-on-approach, which will be useful to both students and professionals already working in bioprocessindustries.

This book provides an integrating framework for the student in chemical and biochemical engineering and the scientist and engineer engaged in process development working in the biochemical, chemical and process industries, as well as biologists, chemists, environmental managers and business economists.

The authors acknowledge the sponsorship of the Deutsche Bundesstiftung Umwelt, Osnabruck, Germany.

This practical book presents the modeling of dynamic biological engineering processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands-on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations. The programs are written in the modern user-friendly simulation language Berkeley Madonna, which can be run on both Windows PC and Power-Macintosh computers.
Madonna solves models comprising many ordinary differential equations using very simple programming, including arrays. It is so powerful that the model parameters may be defined as "sliders," which allow the effect of their change on the model behavior to be seen almost immediately. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be viewed simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance.
The extensive teaching experience of the authors is reflected in this well-balanced presentation, which is suitable for the teacher, student, biochemist or the engineer.

Dieses Buch arbeitet mit einer Motivation, die fUr viele Menschen zur Selbstver standlichkeit geworden ist und die beispielsweise durch den Satz zum Ausdruck kommt: "Ich will auch etwas fUr die Umwelt tun." Es soil aber auch eine Hilfe zur Praxisorientierung sein, die heute fUr Akademiker mehr und mehr notwendig erscheint. Wer sich an der Praxis orientieren will, muss sich mit deren Erfordernis sen auseinandersetzen. In der chemischen Industrie, die vom globalen Wettbewerb entscheidend gepragt ist, erfordert die Praxis vor allem eine hohe Effizienz bei Entwicklung, Umsetzung und Vermarktung von Produkten. Gleichzeitig ist aber auch die Orientierung an der ubrigen Gesellschaft ein wichtiges Anliegen, da die chemische Industrie in komplexer Weise in diese eingebettet ist. Die Anliegen der Gesellschaft als Ganzes sind dabei nicht nur in den gesetzlichen Regelwerken prasent, sondern drucken sich auch durch das "Image" der chemischen Industrie in der Bevolkerung aus. Je deutlicher die Gesellschaft im Allgemeinen spurt, dass ihre Interessen berucksichtigt werden, desto besser ist dieses Image. Aus Sicht der ebenfalls mehr und mehr globalisierten menschlichen Gesellschaft sind die Anliegen Arbeitssicherheit, Konsumentensicherheit und intakte Umwelt zweifellos von zentraler Bedeutung. Die integrierte Entwicklung von chemischen Produkten und Prozessen soil hier als Ausdruck einer umfassenden Verantwortung und als intellektuelle Herausfor derung im Urn gang mit chemischer Technologie dargestellt werden."

Grundlegende, leicht verstandliche Einfuhrung in das Modelling der Fermentationskinetik mit praktischen Lernhilfen.
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