Our work began where the greatest classical morphologists left off; their best work was the start of ours. As our work progressed, the rigidity of basic, previous embryological principles was broken down as scientific knowledge advanced. At the same time, the molecular, biological characterization of the cell surface receptor systems progressed enormously with the invention of numerous monoclonal antibodies. Thus, thymology became once again very important because the thymus is the first and central organ of the human immunological system. Then, the question of immuno-neuroendocrine regulation arose and has only been partially answered. Our book seeks to explore what has not been explored. The topic of thymic epithelial cells is a unique one and has never been explored in any previous book as it is explored in this one.

Only a handful of great thymologists remain in the world today, especially after the great loss the medical community suffered with the passing of Dr. Good, the list includes but is not limited to: Dr. Ritter and Dr. Kendall in England, Dr. Savino in Brazil, Dr. Dardenne in France, Dr. von Gaudecker in Germany, a few others in Belgium and Holland, and it is our hope that Dr. Bodey is among them. Nonetheless, a book on the thymus has not been written in the last five years and a book such as this one has never been. This book is based on a 30-year period of research and includes references from a broad range of sources spanning the globe and all sources, even those that were the beginning of thymic research. The book, thus, is uniquely well rounded, more so that previous works.

Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.

A Paradigm for Decentralized Process Modeling presents a novel approach to decentralized process modeling that combines both trends and suggests a paradigm for decentralized PCEs, supporting concerted efforts among geographically-dispersed teams - each local individual or team with its own autonomous process - with emphasis on flexible control over the degree of collaboration versus autonomy provided. A key guideline in this approach is to supply abstraction mechanisms whereby pre-existing processes (or workflows) can be encapsulated and retain security of their internal artifacts and status data, while agreeing with other processes on formal interfaces through which all their interactions are conducted on intentionally shared information. This book is primarily intended to provide an in-depth discussion of decentralized process modeling and enactment technology, covering both high-level concepts and a full-blown realization of these concepts in a concrete system. Either the whole book or selected chapters could be used in a graduate course on software engineering, software process, or software development environments, or even for a course on workflow systems outside computer science (e.g., in a classical engineering department for engineering design, or in a business school for business practices or enterprise-wide management, or in the medical informatics department of a health science institution concerned with computer-assistance for managed care). Selected portions of the book, such as section 2.2 on Marvel, could also be employed as a case study in advanced undergraduate software engineering courses. A Paradigm for Decentralized Process Modeling is a valuable resource for both researchers and practitioners, particularly in software engineering, software development environments, and software process and workflow management, but also in electrical, mechanical, civil and other areas of engineering which have analogous needs for design processes, environmental support and concurrent engineering, and beyond to private and public sector workflow management and control, groupware support, and heterogeneous distributed systems in general.

Includes overlay and suspension lamps, lanterns, smoke shades and bells, and gas and electric lighting devices.

This book explores the many struggles by various individuals and groups to fix Marie Antoinette's identity and links these struggles to larger destabilizations in social, political and gender systems in pre-Revolutionary and Revolutionary France. Looking at how Marie Antoinette was represented in politics, art, literature and journalism, it reveals how crucial political and cultural contests were enacted 'on the body of the Queen.'

The Glass Industry in Sandwich is a five volume series of books presenting a factual account of glass produced by the glass companies that were located in Sandwich, Massachusetts, between 1825 and 1922. Included are color photos of over 2300 Sandwich glass objects that have been thoroughly researched and authenticated by Sandwich glass experts Raymond E. Barlow and Joan E. Kaiser, who have worked together for twenty-two years. Recognized by the antiques industry as the "Bible" in its field, this magnificent set of books has become a trusted reference used by glass curators of major museums as well as by early American glass collectors, antiques dealers and auctioneers. Each photo is accompanied by dimensions, approximate time of production, and captions that detail methods of manufacture and sources of documentation. Comparisons are made between objects manufactured in Sandwich glass houses and objects produced in foreign and other American factories. Cutware, a General Assortment represents a specialized portion of the fifth and final volume. It features four complete chapters on cut, engraved, and etched glass; an assortment of household and commercial ware; bottles; and a supplement to previously published guides.

The Glass Industry in Sandwich is a five volume series of books presenting a factual account of glass produced by the glass companies that were located in Sandwich, Massachusetts, between 1825 and 1922. Included are color photos of over 2300 Sandwich glass objects that have been thoroughly researched and authenticated by Sandwich glass experts Raymond E. Barlow and Joan E. Kaiser, who have worked together for twenty-two years. Recognized by the antiques industry as the "Bible" in its field, this magnificent set of books has become a trusted reference used by glass curators of major museums as well as by early American glass collectors, antiques dealers and auctioneers. Each photo is accompanied by dimensions, approximate time of production, and captions that detail methods of manufacture and sources of documentation. Comparisons are made between objects manufactured in Sandwich glass houses and objects produced in foreign and other American factories. This final volume contains 283 color photos of a variety of objects, from very fine cut and engraved ware to household, commercial, and scientific necessities that came under the heading of "general assortment" when they were marketed in the 1800's. A supplement to Volumes One, Two, Three and Four features objects that were not available for study at the time the books were written. A roster of 1500 employees and their occupations is included as an aid to documentation. There are still bargains to be had for as little as $10 as illustrated by the little-known or previously undocumented pieces pictured in this volume. Extremely rare articles have increased in value to as much as $35,000. Authorities Raymond E. Barlow and Joan E. Kaiser present to you a compendium of glass identifiable and collectable as Sandwich glass. A price guide is available that lists prices for each piece in clear and assorted colors, and updates the prices listed in previously published Barlow-Kaiser price guides.

The Glass Industry in Sandwich is a five volume series of books presenting a factual account of glass produced by the glass companies that were located in Sandwich, Massachusetts, between 1825 and 1922. Included are color photos of over 2300 Sandwich glass objects that have been thoroughly researched and authenticated by Sandwich glass experts Raymond E. Barlow and Joan E. Kaiser, who have worked together for twenty-two years. Recognized by the antiques industry as the "Bible" in its field, this magnificent set of books has become a trusted reference used by glass curators of major museums as well as by early American glass collectors, antiques dealers and auctioneers. Each photo is accompanied by dimensions, approximate time of production, and captions that detail methods of manufacture and sources of documentation. Comparisons are made between objects manufactured in Sandwich glass houses and objects produced in foreign and other American factories. This final volume contains 283 color photos of a variety of objects, from very fine cut and engraved ware to household, commercial, and scientific necessities that came under the heading of "general assortment" when they were marketed in the 1800's. A supplement to Volumes One, Two, Three and Four features objects that were not available for study at the time the books were written. A roster of 1500 employees and their occupations is included as an aid to documentation. There are still bargains to be had for as little as $10 as illustrated by the little-known or previously undocumented pieces pictured in this volume. Extremely rare articles have increased in value to as much as $35,000. Authorities Raymond E. Barlow and Joan E. Kaiser present to you a compendium of glass identifiable and collectable as Sandwich glass. A price guide is available that lists prices for each piece in clear and assorted colors, and updates the prices listed in previously published Barlow-Kaiser price guides.

A guide to the current prices of Sandwich Glass, keyed to all five volumes of Kaiser and Barlow's The Glass Industry in Sandwich.

A Paradigm for Decentralized Process Modeling presents a novel approach to decentralized process modeling that combines both trends and suggests a paradigm for decentralized PCEs, supporting concerted efforts among geographically-dispersed teams - each local individual or team with its own autonomous process - with emphasis on flexible control over the degree of collaboration versus autonomy provided. A key guideline in this approach is to supply abstraction mechanisms whereby pre-existing processes (or workflows) can be encapsulated and retain security of their internal artifacts and status data, while agreeing with other processes on formal interfaces through which all their interactions are conducted on intentionally shared information. This book is primarily intended to provide an in-depth discussion of decentralized process modeling and enactment technology, covering both high-level concepts and a full-blown realization of these concepts in a concrete system. Either the whole book or selected chapters could be used in a graduate course on software engineering, software process, or software development environments, or even for a course on workflow systems outside computer science (e.g., in a classical engineering department for engineering design, or in a business school for business practices or enterprise-wide management, or in the medical informatics department of a health science institution concerned with computer-assistance for managed care). Selected portions of the book, such as section 2.2 on Marvel, could also be employed as a case study in advanced undergraduate software engineering courses. A Paradigm for Decentralized Process Modeling is a valuable resource for both researchers and practitioners, particularly in software engineering, software development environments, and software process and workflow management, but also in electrical, mechanical, civil and other areas of engineering which have analogous needs for design processes, environmental support and concurrent engineering, and beyond to private and public sector workflow management and control, groupware support, and heterogeneous distributed systems in general.

I. MOLECULAR BIOLOGY OF TUMORS.

1. Brain Tumors

1. Introduction

2. Medulloblastoma

3. Glial Tumors

2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors

1. Introduction

2. The Significance of Immunohistochemistry

3. Original Immunohistochemical Observations

4. Intermediate filaments (IFs)

5. Expression of Homeobox B3, B4, and C6 Gene Products

6. Cell proliferation

7. Epidermal growth factor (EGF) and its receptor (EGFR)

8. p53, the guardian of the integrity of the genome

9. Apoptosis in Brain Tumors

10. Survivin

11. Tumor-related Neoangiogenesis in Childhood Brain Tumors

12. Presence of Matrix Metalloproteinases (MMPs)

13. The MAGE gene family

II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES

3. Experimental Therapies in Brain Tumors

4. Biologic Anti-Neoplastic Therapies

1. Introduction

2. Active nonspecific immunomodulation of natural immunity

3. Thymic hormones

4. Interferons: basic and preclinical studies

5. Tumor Necrosis Factors

6. The discovery of interleukin-2: basic principles

5. The lymphokine activated killer (LAK) cell phenomenon

1. Administration of rIL-2 and LAK cells: preclinical trials

6. Angiogenesis Inhibition in Anti-Neoplastic Therapy

7. Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy

1. Active antigen specific immunotherapy (tumor vaccines)

2. Antigen Presentation within Childhood Brain Tumors

3. Immunosuppression within the Cellular Microenvironment of Childhood Brain Tumors

4. The Dendritic Cell Network

5. Antigen Presentation by DCs

6. The Significance of DCs in Anti-Neoplastic Immunotherapy

8. Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells

1. Introduction

2. Human Cancer Cell Related Antigens

3. Oncogenes and Growth Factors in Neoplastic Cells

4. Antibodies and Neoplastic Cells

5. Anti-neoplastic Immunotherapeutical Regiments Influenced by Immunohistochemistry

6. Human Antibodies

7. Anti-Idiotypic Antibodies

8. Bispecific Antibodies

9. Radiolabeled Antibodies

10. Construction of Immunotoxins

11. Monoclonal Antibodies: Carriers of Drugs, Toxins and Cytotoxic Cells

12. Clinical Trials with Monoclonal Antibodies and their Minimal Toxicity

9. Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-neoplastic Immunotherapy

1. Introduction

2. Cancer/Testis Antigens

3. Detection of Cancer/Testis Antigens in Various Malignant Neoplasms and their Therapeutic Significance

Prologue

III. APPENDIX

10. Materials and Methods

1. Tissues and Tissue Handling

2. Libraries of Antibodies

3. Antigen Retrieval Technique

4. Immunoalkaline Phosphatase Antigen Detection Technique

5. Immunoperoxidase Antigen Detection Technique

6. Controls in Immunocytochemistry

7. Evaluation of the Immunoreactivity (immunostaining)

8. Tissue Processing for Tissue Culture Experiments

9. Preparation of Thymic, Peripheral Blood and Bone Marrow Cell Suspensions

10. Isolation of Cortical Thymocytes

11. Isolation of Thymic Nurse Cells (TNCs)

12. Thymic Stromal Cell (RE & DC) Cultures

13. Proliferation Assay (PA) for Thymocytes and Peripheral Blood Hematopoietic Cells

14. Transmission Electronmicroscopy (TEM) of Cultured Thymic Medullary Cells (RE, DC, including LC, & IDC) and Macrophages

15. Scanning Electronmicroscopic (SEM) Procedure for Tissue Samples

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects:

• Control of tumor cell motility
• Role of tumor-cell adhesion and migration in organ-selective metastasis-formation
• Tumor heterogeneity in relation to invasion and metastasis and its clinical implications
• Tumor angiogenesis, angioprevention, anti-angiogenic therapies and response
• Role of apoptosis in the development, progression and therapy of cancer
• Role of macrophages in tumor development and metastasis
• Pathways of macrophage-mediated tumor progression
• Abnormal variation of immune response against cancer
• Immunological aspects of Marek s disease virus (MDV)-induced lymphoma progression
• A biodynamical model of human T-cell proliferative disorders
• Current methodologies for characterization of tumor directed immune response

Accounts of the Boston and Sandwich Glass Company between 1858 and 1882, the Cape Cod Glass Works 1858-1864, and the Cape Cod Glass Company 1864-1869. Chapters on vases, cologne bottles, witch balls, toys, and specialized containers.

This book explores the many struggles by various individuals and groups to fix Marie Antoinette's identity and links these struggles to larger destabilizations in social, political and gender systems in pre-Revolutionary and Revolutionary France. Looking at how Marie was represented in politics, art, literature and journalism, it reveals how crucial political and cultural contests were enacted 'on the body of the queen.'

"From Deficit to Deluge" takes stock of shifts in scholarly investigation of the origins of French Revolution. During the last decade, scholars have moved beyond "revisionist" historians of the 1970s, who highlighted the monarchy's degeneration into despotism, to explore related conflicts in the realms of finance, social relations, religion, diplomacy, the Enlightenment, and colonial policy. In this book, seven established authorities explore some of these critical intersections, and together they make clear the role that unresolved tensions in these realms played in the essentially political narrative told by post-Marxian revisionist historiography.
While each chapter of "From Deficit to Deluge" focuses upon one site of contention--fiscal, social, religious, diplomatic, ideological, and colonial--they all help to explain how long-standing structural problems of the Old Regime caused a fairly "normal" fiscal crisis to metastasize into a revolution. As the editors show in their introduction and conclusion, the growing democratization of politics sparked by the monarchy's clumsy efforts to solve the fiscal crisis put these wide-ranging problems at the epicenter of political debate, thereby sapping the foundations of royal authority and the social hierarchy.

"From Deficit to Deluge" takes stock of shifts in scholarly investigation of the origins of French Revolution. During the last decade, scholars have moved beyond "revisionist" historians of the 1970s, who highlighted the monarchy's degeneration into despotism, to explore related conflicts in the realms of finance, social relations, religion, diplomacy, the Enlightenment, and colonial policy. In this book, seven established authorities explore some of these critical intersections, and together they make clear the role that unresolved tensions in these realms played in the essentially political narrative told by post-Marxian revisionist historiography.
While each chapter of "From Deficit to Deluge" focuses upon one site of contention--fiscal, social, religious, diplomatic, ideological, and colonial--they all help to explain how long-standing structural problems of the Old Regime caused a fairly "normal" fiscal crisis to metastasize into a revolution. As the editors show in their introduction and conclusion, the growing democratization of politics sparked by the monarchy's clumsy efforts to solve the fiscal crisis put these wide-ranging problems at the epicenter of political debate, thereby sapping the foundations of royal authority and the social hierarchy.

Although the political and military aspects of great-power diplomacy in Eastern Europe during the interwar period have been studied extensively, the economic aspects have been relatively neglected. Drawing on documentary material that has only recently been made available, David Kaiser redresses the balance in his discussion of the expansion of German trade with Eastern Europe during the 1930s and the British and French failure to respond to it. Originally published in 1981. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Although the political and military aspects of great-power diplomacy in Eastern Europe during the interwar period have been studied extensively, the economic aspects have been relatively neglected. Drawing on documentary material that has only recently been made available, David Kaiser redresses the balance in his discussion of the expansion of German trade with Eastern Europe during the 1930s and the British and French failure to respond to it. Originally published in 1981. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Der auf dem Gebiet der Sportmedizin und Sportwissenschaften weltweit als Autoritat anerkannte Autor prasentiert mit diesem Buch eine Gesamtdarstellung von Randgebieten der Sportmedizin, denen bislang wenig Beachtung geschenkt wurde. Die in der sportmedizinischen Literatur bisher vernachlassigten Themen beinhalten Probleme des Sports bei Strafgefangenen, bei Alkoholkranken, in Blindenheimen, Kind und Sport, sportorthopadische Probleme bei Schulern sowie Sport und Intelligenz. Die Moglichkeiten des Einsatzes von Sport zur Suchtpravention oder Suchttherapie werden ebenso diskutiert wie die Wechselwirkungen von Sport und Stress. Weitere Kapitel sind der oxy- metrischen Leistungsbeurteilung, den Grenzproblemen des Sports bei Diabetikern sowie den spezifischen Augen-, Ohren- und Genitalverletzungen im Sport oder auch der neuen Bedrohung durch die AIDS-Erkrankung gewidmet. Das Buch stellt somit eine Bereicherung der bisher erschienenen Fachliteratur dar und richtet sich an Sportarzte, Studenten, Sportlehrer, Trainer, Sportleiter, Verbandsfunktionare, Heimbetreuer und interessierte Sportler selbst.