Philip Seymour Hoffman, Christina Hendricks, Richard Jenkins and John Turturro star in this comedy drama directed by John Slattery and adapted from the novel by Pete Dexter. In the 1970s in the working-class town of God's Pocket, troubled 20-something Leon (Caleb Landry Jones) is seemingly accidentally killed on a building site. At the request of Leon's mother Jeannie (Hendricks), who is convinced there was some foul play, her husband, small-time criminal Mickey Scarpato (Hoffman), investigates the death with the help of his friend Arthur 'Bird' Capezio (Turturro). Meanwhile, the well-known journalist Richard Shellburn (Jenkins) is also searching for the truth behind the incident and gets close to Jeannie in the process.

Award-winning film by the director of 'Amores Perros', Alejandro González Iñárritu. Shot mainly with a hand-held camera, and following a non-linear plot line, the film captures the immediacy and confusion of the moments before, during and after a horrific accident that causes the lives of three disparate people to become interwined. Sean Penn plays Paul Rivers, a mathematics teacher facing up to his pending death from a heart problem, while his distant wife Mary (Charlotte Gainsbourg) hopes to become pregnant from artificial insemination. Naomi Watts is Cristina, mother of two little girls who has overcome a drug-dependent past to achieve a stable, happy marriage and family life. Benicio del Toro plays Jack Jordan, an ex-criminal who has now found Jesus and is struggling to provide for his wife and their two children in a poor area of the town. When tragedy strikes, all three characters must re-evaluate their lives in the face of death. The title refers to the 21 grams a person loses at the moment of death, thought to be the weight of the human soul.