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This book explains theoretical and technological aspects of
amorphous drug formulations. It is intended for all those wishing
to increase their knowledge in the field of amorphous
pharmaceuticals. Conversion of crystalline material into the
amorphous state, as described in this book, is a way to overcome
limited water solubility of drug formulations, in this way
enhancing the chemical activity and bioavailability inside the
body. Written by experts from various fields and backgrounds, the
book introduces to fundamental physical aspects (explaining
differences between the ordered and the disordered solid states,
the enhancement of solubility resulting from drugs amorphization,
physical instability and how it can be overcome) as well as
preparation and formulation procedures to produce and stabilize
amorphous pharmaceuticals. Readers will thus gain a well-funded
understanding and find a multi-faceted discussion of the properties
and advantages of amorphous drugs and of the challenges in
producing and stabilizing them. The book is an ideal source of
information for researchers and students as well as professionals
engaged in research and development of amorphous pharmaceutical
products.
This book explains theoretical and technological aspects of
amorphous drug formulations. It is intended for all those wishing
to increase their knowledge in the field of amorphous
pharmaceuticals. Conversion of crystalline material into the
amorphous state, as described in this book, is a way to overcome
limited water solubility of drug formulations, in this way
enhancing the chemical activity and bioavailability inside the
body. Written by experts from various fields and backgrounds, the
book introduces to fundamental physical aspects (explaining
differences between the ordered and the disordered solid states,
the enhancement of solubility resulting from drugs amorphization,
physical instability and how it can be overcome) as well as
preparation and formulation procedures to produce and stabilize
amorphous pharmaceuticals. Readers will thus gain a well-funded
understanding and find a multi-faceted discussion of the properties
and advantages of amorphous drugs and of the challenges in
producing and stabilizing them. The book is an ideal source of
information for researchers and students as well as professionals
engaged in research and development of amorphous pharmaceutical
products.
This volume is a collection of lectures presented during the 2009
International School on High-pressure Crystal- graphy, which took
place at the Ettore Majorana Center for Scientific Culture, between
June 4 and 14, 2009, in the very picturesque Sicilian town of
Erice. st The 2009 school was the 41 course of the "International
School of Cryst- lography" organized at the Majorana Center and was
directed by Elena Figure 1. Audience, including local Boldyreva
(Novosibirsk University) organizers (orange scarfs) and student and
Przemyslaw Dera (University of participants during one of the
lectures. Chicago). Unmatched support and excellent on-site
organization was provided by the expert team consisting of Prof.
Paola Spadon (Uniersity of Padova), Prof. Lodovico Riva di San
Severino (University of Bologna), Elena Papinutto and Prof. John
Irvin (University of California, San Franciso), aided by great team
of young local organizers ("orange scarfs"). Major part of funding
for the school was provided by a grant from the NATO Science for
Peace and Security program, through which the 2009 Erice school was
recognized as a NATO Advanced Study Institute (ASI).
This volume is a collection of lectures presented during the 2009
International School on High-pressure Crystal- graphy, which took
place at the Ettore Majorana Center for Scientific Culture, between
June 4 and 14, 2009, in the very picturesque Sicilian town of
Erice. st The 2009 school was the 41 course of the "International
School of Cryst- lography" organized at the Majorana Center and was
directed by Elena Figure 1. Audience, including local Boldyreva
(Novosibirsk University) organizers (orange scarfs) and student and
Przemyslaw Dera (University of participants during one of the
lectures. Chicago). Unmatched support and excellent on-site
organization was provided by the expert team consisting of Prof.
Paola Spadon (Uniersity of Padova), Prof. Lodovico Riva di San
Severino (University of Bologna), Elena Papinutto and Prof. John
Irvin (University of California, San Franciso), aided by great team
of young local organizers ("orange scarfs"). Major part of funding
for the school was provided by a grant from the NATO Science for
Peace and Security program, through which the 2009 Erice school was
recognized as a NATO Advanced Study Institute (ASI).
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