Since the publication of the previous edition of Tumors of the Esophagus and Stomach, great advances in many areas of tumor biology have led to a better understanding of the pathogenesis, pathology, and molecular biology of epithelial and stromal malignancies of the upper gastrointestinal tract. Many of these advances have led to specific improvements in diagnosis, prognosis, treatment, and thus, survival in patients affected by these tumors. This edition of the Fascicle was written to highlight these advances, and more specifically, to help pathologists diagnose diseases more accurately and understand how pathology contributes to clinical treatment in the new age of personalized and targeted therapy. Notable advances described in this publication include: 1) expansion of our understanding of the pathologic features and molecular pathogenesis of carcinomas of the esophagus and stomach, most of which develop through a chronic inflammation-metaplasia-dysplasia-carcinoma sequence. Important refinements in the classification of neoplastic precursor lesions have been made since the last AFIP series, including the morphologic and endoscopic subtypes, and this has led to improvements in surgical treatment with a strong trend toward minimization in the form of endoscopic mucosal and submucosal dissections 2) discovery of new diseases, such as gastric adenocarcinoma and proximal polyposis syndrome (GAPPS), a special variant of familial adenomatous polyposis, and significant advances in our knowledge regarding the molecular characterization of genetic polyposis syndromes 3) great expansion in the molecular-pathology correlation, morphologic diversity, classification, and therapeutic options of gastrointestinal stromal tumors (GISTs) 4) reclassification and refinement of prognostic factors related to neuroendocrine tumors 5) improvements in the role of cytology in the diagnosis of tumors of the upper gastrointestinal tract. This book has been written with the pathologist in mind first by using tables that illustrate salient pathologic, molecular, and differential diagnostic features of key entities that are often difficult to distinguish from each other. Specific color photographs of classic tumors and morphologic variants often difficult to recognize are used throughout.

Biopsy Interpretation of the Gastrointestinal Tract Mucosa is your definitive bench reference for the diagnosis of these challenging specimens. One of the best-selling titles in the Biopsy Interpretation Series, its practical, richly illustrative coverage encompasses the most common mucosal biopsies from the esophagus, stomach, small intestine, large intestine, and anus, helping you to evaluate the full range of samples and recognize their distinguishing features. This volume focuses on non-neoplastic entities; Volume Two, also available, is your complete source on neoplastic gastrointestinal lesions. Key Features Successfully navigate both common and unusual issues that arise in the day-to-day interpretation of gastrointestinal biopsies. Entities covered in this volume include: Autoimmune gastritis, sexually transmitted infectious proctitis, inflammatory bowel disease and mimics, medication induced injury, and many others. Enhance your interpretation skills with valuable pearls and pitfalls at the beginning of each chapter. Compare your samples to hundreds of full-color illustrations that capture the characteristic appearance of most mucosal biopsies of the gastrointestinal tract. Access additional illustrations plus 50 multiple-choice review questions in the companion VitalSource eBook! Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click

Biopsy Interpretation of the Gastrointestinal Tract Mucosa is your definitive bench reference for the diagnosis of these challenging specimens. One of the best-selling titles in the Biopsy Interpretation Series, its practical, richly illustrative coverage encompasses the most common mucosal biopsies from the esophagus, stomach, small intestine, large intestine, and anus, helping you to evaluate the full range of samples and recognize their distinguishing features. This volume focuses on neoplastic entities; Volume One, also available, is your complete source on non-neoplastic gastrointestinal lesions. Key Features Successfully navigate both common and unusual issues that arise in the day-to-day interpretation of gastrointestinal biopsies. Entities covered in this volume include: Barrett esophagus, mesenchymal neoplasms such as GIST, schwannoma, and benign fibroblastic polyp, hereditary cancer syndromes, and many more. Enhance your interpretation skills with valuable pearls and pitfalls at the beginning of each chapter. Compare your samples to hundreds of full-color illustrations that capture the characteristic appearance of most mucosal biopsies of the gastrointestinal tract. Access additional illustrations plus 50 multiple-choice review questions in the companion VitalSource eBook! Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click

Selected as a Doody's Core Title for 2022! Closely mirroring the daily sign-out process, Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Neoplastic Biopsies is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. Useful as a daily "scope-side guide," it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report. More than 1,600 high-quality photomicrographs capture the subtle morphologic spectrum of neoplastic processes of the tubular GI tract. Each image is captioned with key diagnostic considerations and includes call-outs showing subtle features and diagnostic clues. Practical tools throughout the text include: Tables that emphasize salient clinicopathologic features, management implications, and therapeutic options o Discussions of how and when to incorporate molecular tools o Checklists for key elements of the diagnostic approach and sample notes for inclusion in pathology reports Relevant endoscopic images, photographs of select gross specimens, and medical figures Brief reviews of normal histology that provide contrast to succeeding patterns "Pearls and Pitfalls" and "Near Misses" sections with lessons from real life sign-out experience "Frequently Asked Questions" sections that discuss common diagnostic dilemmas "Sample Note" sections that offer a template of how to synthesize complicated or especially challenging topics Quizzes in every chapter that provide experience with high-yield, board-style teaching topics Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.
Topics for pathologists covering soft tissue pathology include: Soft Tissue Pseudosarcomas; Spindle cell sarcomas; Myofibroblastoma, Myofibroma and Myopericytoma; Peripheral nerve sheath tumors; Clear cell lesions; Primitive round cell neoplasms; Plexiform neoplasms; Myxoid neoplasms; Epithelioid lesions; Lesions featuring giant cells; Gastrointestinal tract mesenchymal lesions;? Liposarcomas

Effectively evaluate challenging GI biopsies with Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Non-Neoplastic Biopsies! Presented in a format that closely mirrors the daily sign-out process, this one-of-a-kind resource helps you interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. You'll be able to reach confident diagnoses efficiently with this patterns based "scope-side guide".Key Features More than 1,100 images illustrate the full morphologic spectrum of the major patterns of non-neoplastic GI tract pathology - providing abundant and varied examples of each diagnosis. The corresponding text details how to recognize the relevant pattern, arrive at a specific diagnosis, and avoid diagnostic pitfalls. Key structural elements help you to quickly zero in on specific patterns of injury, link the injury patterns with particular etiologies, and master important diagnostic nuances. A high-yield format , replete with checklists, key features, diagnostic pearls and pitfalls, frequently asked questions, and sample notes, provides all the assistance you need to enhance your diagnostic skills Now with the print edition, enjoy the bundled interactive eBook edition , offering tablet, smartphone, or online access to: An online review quiz for each chapter helps you test your understanding of vital concepts and prepare for examinations Complete content with enhanced navigation A powerful search that pulls results from content in the book, your notes, and even the web Cross-linked pages , references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

There have been many advances in the pathology of intestinal tumours since the publication of the Third Series Intestines Fascicle in 2003, but many of the foundations of intestinal tumour diagnosis remain tried and true. Tubular adenomas are still tubular adenomas, but better understanding of serrated polyps has been a key advance in the years since the publication of the Third Series volume. Additionally, developments in molecular biology of colorectal carcinoma have allowed for targeted therapy and refinements to our evaluation of Lynch syndrome, which was termed hereditary nonpolyposis colorectal carcinoma (HNPCC) in the past. Our understanding of other polyposis syndromes has similarly blossomed in the past 15 years. Neuroendocrine tumours have been reclassified in the 2010 World Health Organization classification of gastrointestinal tumours. The molecular basis of gastrointestinal stromal tumours of the intestines has been a subject of great interest as well. In producing this update, this group of authors has enjoyed working together in gathering images and information to update this edition of the Intestines atlas. In doing so, we stand on the shoulders of giants before us, namely Drs. Robert H. Riddell, Robert E. Petras, Geraint T. Williams, and Leslie H. Sobin. While many areas of intestinal tumour pathology are without controversy, the classification and nomenclature for appendiceal tumours remain a subject of debate, including among ourselves. We have attempted to offer information on the various divergent viewpoints where they exist for this topic and others. Our efforts have been synergistic, and we hope that readers will enjoy the many interesting illustrations that we were able to amass.