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Tumors of the Esophagus and Stomach (Hardcover)
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Tumors of the Esophagus and Stomach (Hardcover)
Series: AFIP Atlas of Tumor Pathology, Series 4,
Expected to ship within 12 - 17 working days
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Since the publication of the previous edition of Tumors of the
Esophagus and Stomach, great advances in many areas of tumor
biology have led to a better understanding of the pathogenesis,
pathology, and molecular biology of epithelial and stromal
malignancies of the upper gastrointestinal tract. Many of these
advances have led to specific improvements in diagnosis, prognosis,
treatment, and thus, survival in patients affected by these tumors.
This edition of the Fascicle was written to highlight these
advances, and more specifically, to help pathologists diagnose
diseases more accurately and understand how pathology contributes
to clinical treatment in the new age of personalized and targeted
therapy. Notable advances described in this publication include: 1)
expansion of our understanding of the pathologic features and
molecular pathogenesis of carcinomas of the esophagus and stomach,
most of which develop through a chronic
inflammation-metaplasia-dysplasia-carcinoma sequence. Important
refinements in the classification of neoplastic precursor lesions
have been made since the last AFIP series, including the
morphologic and endoscopic subtypes, and this has led to
improvements in surgical treatment with a strong trend toward
minimization in the form of endoscopic mucosal and submucosal
dissections 2) discovery of new diseases, such as gastric
adenocarcinoma and proximal polyposis syndrome (GAPPS), a special
variant of familial adenomatous polyposis, and significant advances
in our knowledge regarding the molecular characterization of
genetic polyposis syndromes 3) great expansion in the
molecular-pathology correlation, morphologic diversity,
classification, and therapeutic options of gastrointestinal stromal
tumors (GISTs) 4) reclassification and refinement of prognostic
factors related to neuroendocrine tumors 5) improvements in the
role of cytology in the diagnosis of tumors of the upper
gastrointestinal tract. This book has been written with the
pathologist in mind first by using tables that illustrate salient
pathologic, molecular, and differential diagnostic features of key
entities that are often difficult to distinguish from each other.
Specific color photographs of classic tumors and morphologic
variants often difficult to recognize are used throughout.
General
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