Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine.

Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field. The two volumes present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. The immense therapeutic potential is highlighted which arises from the close collaboration of biomedical scientists and biotechnological engineers in this area and signifies the transition from the conventional "resective" surgery to functional neuroprosthetic surgery (Vol. I) and neural networks surgery (Vol. II) which uses neuro-engineering to improve impaired neural function.

Volume I describes techniques and procedures applied in internal contact with non-neural tissues surrounding the nervous system (dura or cerebrospinal fluid), as in the case of epidural stimulation for pain, etc. or intrathecal drug application for the treatment of spasticity and pain. There is also a special section on non-invasive functional neuroprosthetic systems, which are usually applied by transcutaneous contact with the nervous system.