What does it mean to personalise cancer medicine? Drawing on an ethnographic study with cancer patients, carers and practitioners in the UK, this book traces their efforts to access and interpret novel genomic tests, information and treatments as they craft personal and collective futures. Exploring multiple experiences of new diagnostic tests, research programmes and trials, advocacy and experimental therapies, the authors chart the different kinds of care and work involved in efforts to personalise cancer medicine, as well as the ways in which benefits and opportunities are unevenly realised and distributed. Comparing these experiences with policy and professional accounts of the 'big' future of personalised healthcare, the authors show how hope and care are multi-faceted, contingent and, at times, frustrated in the everyday complexities of living and working with cancer. This book is available as an open access ebook under a CC-BY-NC-ND licence. -- .

The almost 300 letters in volume 13 of Adams Family Correspondence were written during seventeen tumultuous months of John Adams's presidency. Consumed with executive duties, he depended on surrogates for much of his correspondence with family members. From Quincy, an ailing Abigail Adams wrote frequent letters to Philadelphia and received lively responses from son Thomas Boylston and the president's secretary, nephew William Smith Shaw. These letters attest to John's popularity in the wake of the XYZ Affair. However, they also chronicle passage of the Alien and Sedition Acts and the Kentucky and Virginia Resolutions, which laid the groundwork for future debates on the relative roles of state and federal governments. Following the break in diplomacy with France, John sensed a change in the footing of the French, acted unilaterally in ordering a second mission to seek a negotiated settlement of the Quasi-War, and faced widespread skepticism about his foreign policy as his envoys departed for Europe. John and Abigail lamented yet another absence from each other. After completing service in Berlin as secretary to diplomat John Quincy, Thomas Boylston established himself as a Philadelphia lawyer, offering thoughtful commentary on political life in the capital. From his post in Prussia, John Quincy struggled with his brother Charles's mismanagement of his financial affairs, but his letters also provide detailed updates on developments in Europe, including Napoleon's invasion of Egypt. The candid letters of John and Abigail Adams and their children offer a rich perspective on life in America during its infancy.

Inside the success of 100 Business Geniuses
Risk-loving entrepreneurs. Innovative geniuses. Self-starters and mavericks. The world's greatest businesses were built by unique people, each bringing their own style and savvy to the marketplace.
100 Great Businesses and the Minds Behind Them is a diverse and inspiring collections of great business stories. Covering a variety of success paths, brilliant strategies and engaging entrepreneurs, each profile explores the genius behind the greatest business minds:
o A mother's inspiration that launched Baby Einstein
o Aveda's journey from hippie to hip
o How Guinness overcame a centuries-old problem to conquer new markets
o TiVo's long fight to explain the genius of their product
o How Oprah went from person to empire
o And many more

An engrossing look at what makes entrepreneurs and business geniuses tick, this book highlights the pivotal moments in the lives of great businesses, with lasting lesson on the art of making your business a success.