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Marijuana is the prototypical cannabinoid, and is one of the most widely used drugs in the world. Cannabinoids are molecules found naturally in the human body and brain as well as in cannabis. This book provides an extensive reference on the biology of marijuana and the role of molecular techniques in elucidating neuropharmacological aspects of cannabinoid receptors and the endogenous compounds that act upon them. Contributions from experts from around the world describe the interaction of cannabinoids and endocannabinoids on a wide range of biological functions including movement, memory and learning, pain, emotions, endocrine functions and many more. The Biology of Marijuana will be of interest to all scientists and clinicians interested in the biological effects and pharmacology of this drug. eBook available with sample pages: 0203219139
Marijuana is the prototypical cannabinoid, and is one of the most
widely used drugs in the world. Interestingly, cannabinoids are
molecules found naturally in the human body and brain as well as in
cannabis. This book provides an extensive reference on the biology
of marijuana and the role of molecular techniques in elucidating
neuropharmacological aspects of cannabinoid receptors and the
endogenous compounds that act upon them. Contributions from experts
from around the world describe the interaction of cannabinoids and
endocannabinoids on a wide range of biological functions including
movement, memory and learning, pain, emotions, endocrine functions
and many more. The Biology of Marijuana: From Gene to Behavior will
be of interest to all scientists and clinicians interested in the
biological effects and pharmacology of this drug.
Over the past decade, there have been major advances in
understanding the mechanisms whereby marijuana interacts with the
brain in producing psychoactive and potentially therapeutic
effects. The discovery of specific gene coding for cannabinoid
receptors activated by smoking marijuana, and the finding of
endogenous cannabinoids, which also activate the receptors, have
transformed cannabinoid research into mainstream science with
significant implications in human health and disease
Endocannabinoids: The Brain and Body's Marijuana and Beyond
documentsadvances in the discovery and functioning of naturally
occurring marijuana-like substances in human biology. It explores
recent findings that point to the existence of an endocannabinoid
physiological control system (EPCS) that directly impacts human
development, health, and disease. While cannabinoid effects on the
brain have received the greatest attention throughout the
literature, this work looks at research on the endogenous
cannabinoid system's association across all of human physiology,
including the immune, endocrine, and reproductive systems. With
thoroughly researched and exceptionally insightful contributions
from more than three-dozen top-flight researchers representing a
cross-section of disciplines from molecular biology, genetics, and
neurology to gynecology, physiology, and pharmacology, this work
explores a range of topics as wide as the human body is complex.
These topics include the EPCS's relation to cell development and
regulation, CNS function, immune function modulation, reproduction,
and digestion, as well as its function in mental illness,
neurodegenerative diseases, and cancer. The final section in the
book considers the significance of endogenous cannabinoids found in
some of the simplest multicellular organisms in the animal kingdom,
as well as in mammalian cells at the earliest stages of
development, all of which suggests that they play a fundamental
role in human biology.
A cutting-edge collection of readily reproducible in vitro and in
vivo methods to elucidate the mechanisms associated with
cannabinoid function in health and disease. The techniques can be
used in studies across the board from genes to behavior. The
molecular neurobiological methods are invaluable in analyzing the
structure, the polymorphisms, and the molecular expression of the
cannabinoid receptors (CBrs), as well as their association with
polysubstance abuse. There are also methods for localizing
cannabinoid receptors in different systems, visualizing cannabinoid
effects using brain slice imaging and elctrophysiological
approaches, and designing and synthesizing cannabinoids and
endocannabinoids. The protocols follow the successful Methods in
Molecular Medicine (TM) series format, each offering step-by-step
laboratory instructions, an introduction outlining the principles
behind the technique, lists of the necessary equipment and
reagents, and tips on troubleshooting and avoiding known pitfalls.
A cutting-edge collection of readily reproducible in vitro and in
vivo methods to elucidate the mechanisms associated with
cannabinoid function in health and disease. The techniques can be
used in studies across the board from genes to behavior. The
molecular neurobiological methods are invaluable in analyzing the
structure, the polymorphisms, and the molecular expression of the
cannabinoid receptors (CBrs), as well as their association with
polysubstance abuse. There are also methods for localizing
cannabinoid receptors in different systems, visualizing cannabinoid
effects using brain slice imaging and elctrophysiological
approaches, and designing and synthesizing cannabinoids and
endocannabinoids. The protocols follow the successful Methods in
Molecular Medicine (TM) series format, each offering step-by-step
laboratory instructions, an introduction outlining the principles
behind the technique, lists of the necessary equipment and
reagents, and tips on troubleshooting and avoiding known pitfalls.
Over the past decade, there have been major advances in
understanding the mechanisms whereby marijuana interacts with the
brain in producing psychoactive and potentially therapeutic
effects. The discovery of specific gene coding for cannabinoid
receptors activated by smoking marijuana, and the finding of
endogenous cannabinoids, which also activate the receptors, have
transformed cannabinoid research into mainstream science with
significant implications in human health and disease
Endocannabinoids: The Brain and Body's Marijuana and Beyond
documentsadvances in the discovery and functioning of naturally
occurring marijuana-like substances in human biology. It explores
recent findings that point to the existence of an endocannabinoid
physiological control system (EPCS) that directly impacts human
development, health, and disease. While cannabinoid effects on the
brain have received the greatest attention throughout the
literature, this work looks at research on the endogenous
cannabinoid system's association across all of human physiology,
including the immune, endocrine, and reproductive systems. With
thoroughly researched and exceptionally insightful contributions
from more than three-dozen top-flight researchers representing a
cross-section of disciplines from molecular biology, genetics, and
neurology to gynecology, physiology, and pharmacology, this work
explores a range of topics as wide as the human body is complex.
These topics include the EPCS's relation to cell development and
regulation, CNS function, immune function modulation, reproduction,
and digestion, as well as its function in mental illness,
neurodegenerative diseases, and cancer. The final section in the
book considers the significance of endogenous cannabinoids found in
some of the simplest multicellular organisms in the animal kingdom,
as well as in mammalian cells at the earliest stages of
development, all of which suggests that they play a fundamental
role in human biology.
Marijuana is one of the most widely used drugs in the world. This
book provides an extensive reference on the biology of marijuana
and the role of molecular techniques in elucidating
neuropharmacological aspects of cannabinoid receptors and the
endogenous compounds that act upon them. Contributions from experts
from around the world describe the interaction of cannabinoids and
endocannabinoids on a wide range of biological functions including
movement, memory and learning, pain, emotions, endocrine functions
and many more. The Biology of Marijuana: From Gene to Behavior will
be of interest to all scientists and clinicians interested in the
biological effects and pharmacology of this drug.
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